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Symptom-related sputum microbiota in stable chronic obstructive pulmonary disease

Authors Diao W, Shen N, Du Y, Erb-Downward JR, Sun X, Guo C, Ke Q, Huffnagle GB, Gyetko MR, He B

Received 8 March 2018

Accepted for publication 12 June 2018

Published 30 July 2018 Volume 2018:13 Pages 2289—2299

DOI https://doi.org/10.2147/COPD.S167618

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Charles Downs

Peer reviewer comments 2

Editor who approved publication: Dr Chunxue Bai


Wenqi Diao,1,* Ning Shen,1,* Yipeng Du,1,* John R Erb-Downward,2 Xiaoyan Sun,1 Chenxia Guo,1 Qian Ke,1 Gary B Huffnagle,2,3 Margaret R Gyetko,2 Bei He1

1Department of Respiratory Medicine, Peking University Third Hospital, Beijing 100191, China; 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA; 3Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA

*These authors contributed equally to this work

Background: The role of airway microbiota in COPD is highly debated. Symptomology assessment is vital for the management of clinically stable COPD patients; however, the link between symp­toms and the airway microbiome is currently unknown.
Purpose: The present study aimed to evaluate the relationship among stable COPD patients.
Patients and methods: We conducted pyrosequencing of bacterial 16S rRNA using induced sputum samples in a Han Chinese cohort that included 40 clinically stable COPD patients and 19 healthy controls.
Results: Alterations in community composition and core bacte­rial taxa (Neisseria subflava, etc.) were observed in patients with severe symptoms compared with controls. The co-occurrence network indicated that the key microbiota enriched in COPD patients showed higher expression in patients with severe symptoms. The association pattern of symptoms with the sputum microbiome was obviously different from that of lung function in COPD patients.
Conclusion: These findings broaden our insights into the relationship between the sputum microbiota and the symptom severity in COPD patients, emphasizing the role of symptoms in the airway microbiome, independent of lung function.

Keywords: chronic obstructive pulmonary disease, symptom, sputum, microbiome

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