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Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats

Authors Zhuang DS, Han JL, Bi LJ, Wang YP, Hao YR, Zhou Q, Cao WW

Received 6 February 2015

Accepted for publication 17 March 2015

Published 6 May 2015 Volume 2015:9 Pages 2545—2551

DOI https://doi.org/10.2147/DDDT.S82347

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2


Deshu Zhuang,1 Jialong Han,1 Liangjia Bi,1 Yueping Wang,1 Yanru Hao,2 Qi Zhou,3 Wenwu Cao3,4

1Department of Stomatology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China; 2Department of Stomatology, The First Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China; 3Condensed Matter Science and Technology Institute, Harbin Institute of Technology, Harbin, People’s Republic of China; 4Department of Mathematics and Materials Research Institute, The Pennsylvania State University, University Park, PA, USA

Objectives: The aim of this study was to perform a histological evaluation of sonodynamic therapy (SDT) of hematoporphyrin monomethyl ether (HMME) on artificially induced periodontal disease in rats.
Methods: Submerging ligatures were placed at the subgingival region of the first maxillary molar in rats. Eighty rats were randomly assigned into four groups: group 1 received no treatment; group 2 was subjected to 50 µg/mL HMME alone; group 3 was treated with low-intensity ultrasound alone (1 W/cm2); and group 4 was treated with 50 µg/mL HMME plus ultrasound irradiation (1 MHz, 30 minutes). Ten rats in each group were euthanized at 7 and 15 days, and periodontal tissue samples were taken for histological examination.
Results: The animals treated by SDT showed less bone loss (P<0.05) at all experimental periods than the other three groups. No significant differences were found between the control and HMME groups (P>0.05).
Conclusion: Our results suggest that HMME-mediated SDT can effectively alleviate the periodontal tissue destruction in artificially induced periodontitis in rats. Hence, SDT may have good clinic potential as a noninvasive treatment of periodontal diseases.

Keywords: periodontal tissues, sonodynamic therapy, histology, alveolar bone loss, animal studies

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