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Serum trace elements in insulin-dependent and non-insulin-dependent diabetes: a comparative study

Authors Ahmed AM, Khabour OF, Awadalla AH, Waggiallah HA

Received 5 September 2018

Accepted for publication 6 November 2018

Published 4 December 2018 Volume 2018:11 Pages 887—892

DOI https://doi.org/10.2147/DMSO.S186602

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Steven F. Abcouwer


Ahmed M Ahmed,1 Omar F Khabour,1,2 Akram H Awadalla,3 Hisham A Waggiallah4

1Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Taibah University, Medina, Saudi Arabia; 2Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan; 3Department of Clinical Chemistry, College of Medical Laboratory Sciences, Kordofan University, Alobayid, Sudan; 4Department of Medical Laboratory Sciences, Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia

Background: Diabetes mellitus is associated with imbalance in body trace elements. The aim of the current investigation was to compare the levels of trace elements (Zn, Mg, Mn, Cu, Na, K, Fe, Ca, Cr, and Se) in insulin dependent (IDDM) and non-insulin dependent (NIDDM) diabetes.
Methods: A total of 100 patients with diabetes (40 IDDM and 60 NIDDM) and 50 healthy subjects were recruited in the study from both genders. Biochemical measures include glucose, lipids, and HbA1C.
Results: The results showed that Zn, Mg, Cu and Cr were significant lower in patients with diabetes compared to the control group (P<0.01). In addition, Zn and Cr were significantly lower in IDDM than NIDDM (P<0.05). Moreover, Zn and Mg levels were inversely correlated with HbA1c in IDDM and NIDDM (P<0.05). Zn was inversely correlated with fasting blood glucose in IDDM (P<0.05). Finally, no correlation between trace element levels with BMI was found (P>0.05).
Conclusion: Disturbance in trace element profile among IDDM and NIDDM is similar.

Keywords:
trace elements, diabetes mellitus, IDDM, NIDDM

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