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Selective Serotonin Reuptake Inhibitor-Induced Sexual Dysfunction: Current Management Perspectives

Authors Atmaca M

Received 4 March 2019

Accepted for publication 7 April 2020

Published 20 April 2020 Volume 2020:16 Pages 1043—1050

DOI https://doi.org/10.2147/NDT.S185757

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder


Murad Atmaca

Department of Psychiatry, Firat University School of Medicine, Elazig, Turkey

Correspondence: Murad Atmaca
Firat (Euphrates) Universitesi, Firat Tip Merkezi, Psikiyatri Anabilim Dali, Elazig 23119, Turkey
Tel +90 424 233 3555
Fax +90 424 238 7688
Email matmaca_p@yahoo.com

Abstract: Any type of sexual dysfunction is an important problem in half of the patients with depressive disorder. On the other hand, one to a quarter of people without any depressive disorder experience sexual dysfunction. Antidepressant agents can lead to all types of sexual side effects including arousal, libido, orgasm and ejaculation problems. Selective serotonin reuptake inhibitors (SSRIs) are a widely used class of drugs which are prescribed for the treatment of a variety of disorders, including major depressive disorder, obsessive-compulsive disorder, posttraumatic stress disorder, panic disorder, generalized anxiety disorder, and impulse control disorders. It has been reported that one in eight people have utilized one of the SSRIs in the past 10 years. Some studies reported up to 80% of SSRI-induced sexual side effects. Management of SSRI-induced sexual dysfunction seems to be complex and hard. In this paper, SSRI-induced sexual dysfunction and new perspectives in the management of this problem were reviewed.

Keywords: SSRI, sexual dysfunction, current perspectives

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