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Scopolamine alleviates involuntary lingual movements: tardive dyskinesia or dystonia?

Authors Hu JB, Lai JB, Hu SH, Xu Y

Received 14 June 2017

Accepted for publication 14 August 2017

Published 31 August 2017 Volume 2017:13 Pages 2327—2330

DOI https://doi.org/10.2147/NDT.S143970

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Roumen Kirov

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder

Jianbo Hu,1,2,* Jianbo Lai,1,2,* Shaohua Hu,1,2 Yi Xu1,2

1Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; 2The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou, China

*These authors contributed equally to this work


Abstract: Cholinergic hypofunction was believed to be associated with the pathogenesis of tardive dyskinesia, and therefore, anticholinergic treatment might exacerbate the condition. We describe herein a middle-aged male with feeble chewing movements, involuntary rolling motions of the tongue, and abnormally tightened cheeks which developed after consuming different psychotropic medications. These symptoms did not improve after routine treatment for tardive dyskinesia, but responded well to anticholinergic agents, such as scopolamine and benzhexol hydrochloride. This case extended our understanding of the complexity of extrapyramidal effects and their pharmacologic management.

Keywords: neuroleptic, scopolamine, tardive dyskinesia, dystonia

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