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RRM1 expression and the clinicopathological characteristics of patients with non-small cell lung cancer treated with gemcitabine

Authors Chen Y, Huang Y, Chen DM, Wu C, Leng QP, Wang WY, Deng MQ, Zhao YX, Yang XH

Received 16 January 2018

Accepted for publication 9 July 2018

Published 7 September 2018 Volume 2018:11 Pages 5579—5589

DOI https://doi.org/10.2147/OTT.S162667

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Geoffrey Pietersz


Ying Chen,1,* Ying Huang,2,* Dong-Ming Chen,2,* Chao Wu,1 Qiu-Ping Leng,1 Wen-Yi Wang,1 Ming-Qin Deng,1 Yan-Xia Zhao,1 Xiao-Hong Yang1

1Department of Respiratory and Critical Care Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China; 2Graduate School of Xinjiang Medical University, Urumqi 830001 Xinjiang, China

*These authors contributed equally to this work

Background: The usefulness of ribonucleotide reductase catalytic subunit M1 (RRM1) for predicting the therapeutic effects of gemcitabine-containing chemotherapy in patients with non-small cell lung cancer (NSCLC) remains controversial. RRM1-positive patients show unique clinicopathological features.
Methods: Here, we performed a meta-analysis to systematically evaluate the relationship between RRM1 expression and the clinicopathological characteristics of NSCLC patients treated with gemcitabine-containing regimens. A comprehensive electronic and manual search was performed to identify relevant articles. The pooled relative risk (RR) and 95% CI were used to estimate the relation between the clinicopathological characteristics of NSCLC patients and RRM1 expression.
Results: The study included 31 observational studies and 3,667 patients. The analysis showed no significant association between RRM1 expression and pathological type, stage, and smoking status; however, RRM1 positivity was significantly lower in women than in men (43.0% vs 51.7%, RR=0.84, 95% CI: 0.74–0.94, P=0.004).
Conclusion: The present pooled analyses demonstrated that RRM1 positivity in women with advanced NSCLC was associated with a higher rate of response to gemcitabine-containing regimens. Immunohistochemistry may be valuable to prescreen for RRM1 expression in clinical practice, whereas PCR can be routinely used as a verification method. These findings will help design suitable molecular-targeted therapies for NSCLC.

Keywords:
RRM1, gemcitabine, meta-analysis, clinicopathological features, NSCLC

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