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Risk Factors for New Vertebral Fracture After Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures

Authors Zhang ZL, Yang JS, Hao DJ, Liu TJ, Jing QM

Received 30 March 2021

Accepted for publication 27 May 2021

Published 22 June 2021 Volume 2021:16 Pages 1193—1200


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Nandu Goswami

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Zi-Long Zhang,1,2,* Jun-Song Yang,1,* Ding-Jun Hao,1 Tuan-Jiang Liu,1 Qi-Ming Jing2,*

1Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Graduate School of Xi’an Medical University, Xi’an, Shaanxi, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Ding-Jun Hao
Department of Spine Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi’an City, Shaanxi Province, People’s Republic of China
Email [email protected]

Purpose: To analyze the risk factors for new vertebral fractures after percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures (OVCFs).
Patients and Methods: We retrospectively reviewed the records of patients with symptomatic OVCFs who underwent PVP in our hospital, from January 2014 to January 2019. Demographic and lifestyle data on the presence of underlying chronic disease, preoperative bone mineral density, details of vertebral fractures, postoperative osteoporosis treatment, and new fracture development were collected. Patients were divided into postoperative fracture and non-fracture groups. To identify the independent risk factors for new vertebral fracture development, variables significant on univariate analysis were included in a multivariate regression model.
Results: Of the 2202 patients treated with PVP, 362 (16.43%) had a new postoperative vertebral fracture. All patients were followed up for > 12 months (mean 14.7 months). Univariate analysis revealed no significant difference in height; body weight; preoperative bone mineral density; number of fractured vertebrae; injection volume of bone cement in a single vertebra; leakage rate of bone cement; or presence of hypertension, coronary heart disease, and chronic obstructive pulmonary disease between the fracture and non-fracture groups (P> 0.05). Age, sex, smoking, alcohol consumption, diabetes mellitus, postoperative exercise, and postoperative osteoporosis treatment were associated with new vertebral fractures (all P< 0.05). A multivariate analysis showed that age (odds ratio [OR]=1.212, P< 0.0001), female sex (OR=1.917, P< 0.0001), smoking (OR=1.538, P=0.026), and diabetes (OR=1.915, P< 0.0001) were positively correlated with new vertebral fracture development, whereas postoperative exercise (OR=0.220, P< 0.0001) and osteoporosis treatment (OR=0.413, P< 0.0001) were negatively correlated.
Conclusion: Elderly patients, females, and those with a history of smoking and diabetes are at high risk of new vertebral fracture after PVP. Patients should be encouraged to stop smoking and consuming alcohol, control blood glucose level, participate in sufficient physical activity, and adhere to osteoporosis treatment to prevent new vertebral fractures.

Keywords: aged, fractures, compression, osteoporosis, risk factors, spinal fractures, vertebral body


Osteoporosis is a progressive disease of bone loss that gradually develops with aging.1 Although the onset is insidious, the potential for harm is great. Frequently, falls or injuries lead to osteoporotic fractures in the elderly, among which spinal thoracolumbar fractures are the most common.2 Since its development in 1987, percutaneous vertebroplasty (PVP) can effectively relieve pain and recover vertebral body height, with minimal trauma and quick recovery time; it has become the treatment of choice in osteoporotic vertebral compression fractures (OVCFs).3,4 Postoperatively, there is a high incidence of developing a new vertebral fracture, a long-term complication of PVP. The incidence of new fracture development in patients aged under 80 years is reportedly 9%, whereas, it is 33% for those aged over 80 years.5 Studies have confirmed that sex, age, and bone cement-related factors influence the development of new vertebral fractures after PVP.6 As osteoporosis is closely related to lifestyle factors, such as smoking, alcohol consumption, and physical activity, it is thought that these same factors will affect the incidence of new vertebral fractures postoperatively. However, no definitive evidence is available to support this theory. Indeed, it is unclear whether treatment of lifestyle-related factors will reduce the incidence of new vertebral fracture development. In this study, based on a large dataset from our hospital, the risk factors for the development of a new vertebral fracture in patients with OVCFs after PVP were explored by multi-factor regression analysis.

Materials and Methods

This was a retrospective cohort study, which included 2202 inpatients who underwent PVP for symptomatic OVCFs at our hospital over a 5-year period, from January 2014 to January 2019. We reviewed each patient’s clinical records and extracted information onto a pre-arranged database.

Inclusion Criteria

The inclusion criteria were as follows: 1) preoperative magnetic resonance imaging (MRI) confirming an OVCF and fat suppression imaging showing high-signal intensity in the fractured vertebral body; 2) PVP; 3) bone mineral density T score ≤-2.5, as measured by preoperative dual-energy X-ray; 4) follow-up time >1 year; and 5) complete clinical and imaging data.

Exclusion Criteria

The exclusion criteria were as follows: 1) symptomatic low back and leg pain caused by other reasons (disc herniation, vertebral spondylolisthesis, spondylolysis, and others), 2) infectious diseases, 3) a malignant spinal tumor, 4) paralysis or inability to move autonomously, and 5) an unwillingness to return for follow-up visits.

Patients were followed up regularly at 1, 3, 6, and 12 months after surgery. After 12 months, doctors decided whether to extend the review time according to the degree of recovery of patients. A thoracolumbar X-ray examination was performed during the review. If the patient had a sudden onset of back pain during the follow-up period, X-ray imaging and MRI were performed to determine the occurrence of a new vertebral fracture. The criteria for the development of a new postoperative vertebral fracture included recurrent back pain after PVP; percussion pain occurring at corresponding segments; and fat suppression T2-weighted MRI showing a high-signal intensity of the fractured vertebral body, with or without a vertebral compression fracture.7

The following information was recorded for each patient: basic demographic data (sex, age, height, and weight), preoperative bone mineral density (absolute values), the number of vertebral body fractures, a single vertebral body bone cement injection, bone cement leakage rate, lifestyle-related factors (smoking, drinking, and postoperative exercise), and presence of chronic diseases (hypertension, diabetes, coronary atherosclerosis, and chronic obstructive pulmonary disease). At each postoperative review, the patients were asked whether they followed the doctor’s advice to exercise and whether they had undergone osteoporosis treatment.

Exercise was defined as aerobic exercise, including brisk walking, jogging, dancing, swimming, and climbing, that increased the heart rate for at least 30 min and was performed for a minimum of four times a week.

Medications for osteoporosis treatment included calcitonin and bisphosphonates. According to the treatment plan prescribed by the doctor at discharge, during the review period, medication was to be taken regularly according to the treatment course (including calcitonin and bisphosphonates used in our hospital) for at least 12 months.

Statistical Methods

Continuous data are expressed as means±standard deviations, and the independent samples t-test was used for comparison between groups. Categorical data were analyzed by a chi-square test. A univariate analysis was used to identify potential influencing factors for new vertebral fracture after PVP. A multivariate logistic regression analysis was conducted using the variables with statistical significance in the univariate analysis. All statistical analyses were performed using SPSS Statistics for Windows, version 23.0 (IBM Corp, Armonk, NY, USA). A P value of <0.05 was considered statistically significant.


In this study, a total of 2202 patients were followed up for at least 12 months, with an average follow-up time of 14.7 months. These included 569 males, aged 55–82 years (mean=67 years), and 1633 females, aged 52–84 years (mean=64 years). Patients’ demographic details are shown in Table 1. Among the total participants, 362 patients with a new postoperative vertebral fracture (16.43%) were classified as the fracture group, while the remaining 1840 patients with no new postoperative vertebral fracture were classified as the non-fracture group.

Table 1 Univariate Analysis of New Vertebral Fracture After Vertebroplasty

Univariate Analysis

There was no significant difference in height and weight between the fracture and non-fracture groups (P>0.05), as well as in absolute preoperative bone mineral density, number of fractured vertebrae, injection volume of bone cement in a single vertebra, and leakage of bone cement (all P>0.05). In terms of hypertension, coronary heart disease, chronic obstructive pulmonary disease, and other complications, there was no statistical significance in the proportion of patients between the two groups (P>0.05).

The mean age of the fracture group was significantly higher than that of the non-fracture group, (t=−14.020, P<0.0001); the proportion of female patients in the fracture group (83.1%) was significantly higher than that in the non-fracture group (72.4%; x2=18.268, P<0.0001); the percentage of smokers in the fracture group (15.2%) was significantly higher than that in the non-fracture group (10.2%; x2=7.825, P=0.005); the proportion of alcohol drinkers in the fracture group (12.7%) was significantly higher than that in the non-fracture group (8.3%; x2=7.098, P=0.008); the percentage of diabetic patients in the fracture group (30.1%) was significantly higher than that in the non-fracture group (22.9%; x2=8.511, P=0.004); the proportion of people performing adequate exercise postoperatively in the fracture group (47.2%) was significantly lower than that in the non-fracture group (81.9%; x2=200.444, P<0.0001); and the proportion of patients in the fracture group undergoing osteoporosis treatment (21.3%) was significantly lower than that in the non-fracture group (39.7%; x2=44.125, P<0.0001). Table 1 shows the results of the univariate analysis.

Multivariate Analysis

The independent risk factors that positively correlated with new fracture development after PVP were as follows: age (odds ratio [OR]=1.212, 95% confidence interval [CI] =1.174–1.252, P<0.0001), female sex (OR=1.917, 95% CI=1.379–2.665, P<0.0001), smoking (OR=1.538, 95% CI=1.054–2.245, P=0.026), and diabetes (OR=1.915, 95% CI=1.438–2.551, P<0.0001). Postoperative exercise (OR=0.220, 95% CI=0.169–0.286, P<0.0001) and osteoporosis treatment (OR=0.413, 95% CI=0.305–0.560, P<0.0001) were negatively correlated with new vertebral fracture development after PVP. Table 2 and Figure 1 show the results of multivariate analysis.

Table 2 Multivariate Logistic Regression Analysis of New Vertebral Fracture After Vertebroplasty

Figure 1 Risk factores of new vertebral fracture after vertebroplasty.


As a surgical treatment for OVCFs, PVP is easy to perform and has a good analgesic effect. As a common complication of PVP, new vertebral fracture development is a troublesome concern for patients and clinicians. Many factors, including sex, age, diffusion of bone cement, and lifestyle factors, may influence this complication.5,6 Osteoporosis is a chronic progressive disease that is hidden, and in the absence of external intervention, it is unlikely to improve as it is difficult to rely on bones healing independently.8 A good healing environment postoperatively is exacerbated by chronic diseases, their treatments, and lifestyle factors. We expanded the search for independent risk factors for new vertebral fractures after PVP by including factors, such as bone cement leakage and volume status, presence of smoking and alcohol consumption, presence of chronic disease, postoperative osteoporosis treatment, and adequate postoperative exercise. Significant factors for the development of new vertebral fractures included age, sex, smoking and alcohol consumption, presence of diabetes, adequate postoperative exercise, and postoperative osteoporosis treatment.

Age and Sex

Age is an important factor affecting the degree of osteoporosis, and bone mass loss increases gradually with age. Warden et al9 argued that the main reason for bone loss with increasing age is a gradual reduction in calcium intake, with increased excretion of calcium. This results in lower serum calcium level and a secondary increase in parathyroid hormone level, leading to decreased bony calcium deposition. In our study, increasing age was a risk factor for new vertebral fracture development after PVP. Similarly, female sex was also an independent risk factor, mainly related to the unique physiology of women. In postmenopausal women, estrogen loss alters bone metabolism by increasing osteoclast activity, resulting in greater bony absorption than bone formation. This imbalance in bone homeostasis increases bone brittleness.10,11 The risk of postmenopausal osteoporosis increases the risk of vertebral fracture by three to four-fold compared with men of the same age.12 Therefore, elderly patients, especially females, should be informed of the high risk of re-fracture after surgery. Clinicians also need to be vigilant and should consider shortening the review period, prolonging the follow-up period, and timely assessment of any new postoperative back pain.

Lifestyle Factors

There are approximately 1.3 billion smokers worldwide.13 Tobacco contains upto 1000 kinds of harmful substances, among which nicotine has been proven to have a malignant effect on bone.14 In particular, nicotine affects the bones’ blood supply and ability to heal.15 Costa-Rodrigues et al16 showed that nicotine in smokers’ plasma could act directly on osteoclasts and induce differentiation and worsening of osteoporosis. Joehanes et al17 conducted genetic tests on 15,907 blood samples and showed that harmful substances in tobacco could cause DNA methylation; this affects the regeneration and transformation of bone tissue, causing or aggravating osteoporosis. The degree of DNA methylation is much higher in smokers than in non-smokers.17 In our study, smoking was an independent risk factor for new vertebral fracture development after PVP. Therefore, patients should be encouraged to stop smoking postoperatively. Although females are less likely to smoke than males, they are more vulnerable to the effects of secondhand smoke. Kim et al18 showed that long-term exposure to secondhand smoke could increase the incidence of osteoporosis in female non-smokers. Therefore, if a patient’s family member is a smoker, they too should be advised to stop smoking. Kiyota et al19 confirmed that the disruption of bone homeostasis induced by smoking could recover gradually after smoking cessation. Therefore, stopping smoking postoperatively will help prevent the occurrence of new fractures.

Studies have shown that alcohol intake can affect osteoporosis development. Alcohol is metabolized to acetaldehyde, which inhibits osteoblasts.19 However, despite there being a significant difference in the proportion of alcohol drinkers in the fracture group than in the non-fracture group in univariate analysis, this was not significant in multivariate analysis. This could be because we did not measure the amount of alcohol consumed. Previous studies have shown that ethanol has a dose-dependent effect on bone remodeling,20 and individuals have different degrees of tolerance to alcohol, which may have biased our results.

The incidence of diabetes is increasing yearly. In addition to damaging the blood vessels and nerves, diabetes is harmful to the bones. Botolin et al21 found that both type 1 and type 2 diabetes can affect bone remodeling and stem cell differentiation, thus, affecting bone strength and leading to changes in bone density and structure. A prospective study by Schwartz et al22 showed that whether due to insufficient insulin or insulin resistance, excessive blood glucose level impairs the osteoblast’s ability to synthesize bone due to reduced osteocalcin, thus, aggravating osteoporosis. In this study, diabetes was a risk factor for new vertebral fracture after PVP (OR=1.915, 95% CI= 1.438–2.551, P<0.0001). Therefore, it is important for diabetic patients to maintain good control of their blood glucose level postoperatively to prevent the development of new fractures. Viollet et al23 found that drugs, such as metformin, can improve insulin sensitivity and promote the activity of osteoblasts, thus, increasing bone density and delaying the progression of osteoporosis. Therefore, postoperative PVP patients and diabetes mellitus can delay or prevent the progression of osteoporosis and prevent new vertebral fracture development by achieving good blood glucose control.

Postoperative Exercise and Osteoporosis Treatment

At present, most studies have confirmed that at least 3 h of physical activity per week is beneficial to the improvement of bone mineral density.24–26 The main cause of OVCFs is falling. Elderly patients are more prone to falls due to nerve and muscle degeneration, resulting in reduced coordination. Additionally, insufficient physical activity is an important risk factor leading to bone loss. Tinetti et al27 showed that being sedentary with insufficient exercise significantly increases bone loss. To avoid new vertebral fractures following PVP, physical activity is indispensable to the recovery process. Sufficient and appropriate physical activity can effectively restore and strengthen skeletal muscle, prevent muscle atrophy, improve reaction times, maintain stability and coordination, and thus, reduce the risk of falls. Sherrington et al28 analyzed almost 19,500 osteoporotic participants and showed that postoperative exercise could effectively reduce the incidence of falls in the elderly; indeed, in our study, postoperative exercise (OR=0.220, 95% CI= 0.169–0.286, P<0.0001) was a protective factor for new vertebral fracture development after PVP, indicating that 30 min of exercise at least four times a week was beneficial. However, some patients cannot adhere to an exercise regimen after hospital discharge due to a fear of repeat falls. Doctors should educate patients on the importance of postoperative physical activity and encourage them to participate in sports and exercise. A prospective study of patients with spinal fracture conducted by Deng et al29 showed that postoperative exercise to strengthen back muscles could effectively improve physical function, relieve pain, maintain bone density, and greatly reduce the risk of re-fracture. Howe et al30 followed up 4320 patients to assess the impact of exercise on bone mineral density over time. Compared with those who did not exercise, the rate of postoperative bone loss in patients who exercised was reduced. This further supports the findings of our study.

Osteoporosis can be caused by many factors, including nerve and endocrine factors; however, its main cause is bone loss. Once this starts, it is difficult to prevent or reverse progression by solely relying on the patient’s regulatory mechanisms.8 This is compounded by the insidious onset of osteoporosis, lack of early clinical signs,2 and poor awareness, implying that the potential for harm is significant. Osteoporosis medication can effectively prevent or even reverse bone loss.31 Hoff et al32 screened 28,461 volunteers and analyzed the effects of osteoporosis medication on fracture incidence, which was significantly lower in the treated than in the untreated group, thus, highlighting the importance of medical interventions for bone loss. In our study, postoperative osteoporosis treatment (OR=0.413, 95% CI=0.305–0.560, P<0.0001) was a protective factor for new vertebral fractures. We used calcitonin and bisphosphonates to treat osteoporosis. Their main function is to inhibit osteoclast activity and reduce bone resorption, effectively preventing bone loss.33,34 Saag et al35 showed that the rate of bone loss was reduced after the administration of bisphosphonates. Therefore, to prevent new vertebral fractures after PVP, clinicians should inform patients of the harms of osteoporosis, outline preventative measures, and recommend postoperative osteoporosis treatment.


The results obtained from our univariate and multivariate analyses reinforce the previous suggestions in smaller series, which, however, reported a higher incidence of adjacent fracture than what we observed (20% vs 16%).The difference may have been caused by the difference in sample size.36 This was a single-center retrospective study, and only patients who underwent PVP were included. We chose not to include patients with percutaneous kyphoplasty because their postoperative outcomes are different from those of PVP patients. In addition, the method of anesthesia employed may have impacted postoperative re-fracture rates. Postoperative exercise methods were not further detailed; thus, we could not explore whether different kinds of physical activity would have different impacts on bone loss. In terms of lifestyle factors, smoking and alcohol consumption were not included in the further analysis for specific dose-effect relationships. Only calcitonin and bisphosphonate drugs were included, and other drugs were excluded from the analysis. Hence, further studies with larger samples, multiple risk factors, and detailed classifications are needed.


Elderly patients, females, and those with a history of smoking and diabetes are at higher risk of new vertebral fracture development after PVP. Patients should be advised to stop smoking, to reduce alcohol consumption, and to achieve good blood glucose control after PVP. In addition, they should be encouraged to engage in adequate levels of physical activity and to adhere to osteoporosis treatments to prevent new vertebral fractures.


CI, confidence interval; MRI, magnetic resonance imaging; OR, odds ratio; OVCF, osteoporotic vertebral compression fracture; PVP, percutaneous vertebroplasty; BMD, bone mineral density.

Data Sharing Statement

Data will be made available upon reasonable request to the corresponding author.

Ethics Approval and Informed Consent

The study was conducted in agreement with the Declaration of Helsinki and was approved by the Ethics Committee of the Honghui Hospital in China (201312002). All participants gave written informed consent.


We would like to thank the patients for their willingness to participate in our study.

Author Information

Zi-Long Zhang Men, born in 1994, is a spinal surgeon in Honghui Hospital engaged in clinical research related to spinal surgery.

Author Contributions

All authors have agreed on the journal to which the article will be submitted. Additionally, all authors have reviewed and agreed on all versions of the article before submission and during revision, the final version accepted for publication, and any significant changes introduced during proofreading.


We would like to thank Chinese national natural science foundation (No.81830077 for Ding-Jun Hao) for providing the grant.


The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.


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