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Retinal Artery Contraction After Phenylephrine as a Cardiovascular Risk Biomarker

Authors Casado A, López-de-Eguileta A, Fonseca S, Cerveró A, Gaitán J

Received 29 January 2020

Accepted for publication 1 April 2020

Published 11 May 2020 Volume 2020:14 Pages 1269—1275


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Alfonso Casado, Alicia López-de-Eguileta, Soraya Fonseca, Andrea Cerveró, Jorge Gaitán

Department of Ophthalmology, Hospital Universitario Marqués de Valdecilla, Santander, Spain

Correspondence: Jorge Gaitán
Ophthalmology Department, Hospital Marqués de Valdecilla, Av. Valdecilla, 25, Santander 39008, Cantabria, Spain
Tel +34 605762803

Background and Aim: We investigated the in vivo changes of artery diameter (AD) and vein diameter (VD) after topical phenylephrine 2.5% instillation, and its relationship with the Systematic Coronary Risk Evaluation (SCORE).
Methods: This is a cross-sectional study. Healthy control patients were included. All of the participants underwent enhanced depth imaging by spectral-domain optical coherence tomography before and 30 minutes after phenylephrine instillation, using eye-tracking and follow-up software. Changes in AD and VD were assessed.
Results: The study included 45 eyes of 45 patients (14 males and 31 females). The mean age was 58.6 ± 15.1 years (26– 88 years). Mean SCORE risk estimation value was 2.0 (0– 14). No significant correlation was found between pre-phenylephrine AD or VD with age (p=0.237 and p=0.821, respectively), SCORE (p=0.545 and p=0.723, respectively). AD significant thinned after phenylephrine (p< 0.001), whereas no significant changes could be depicted in VD (p=0.474). Changes in AD after phenylephrine were significantly related with SCORE risk estimation (p=0.035). Discordantly, changes in VD after phenylephrine were not significantly related with SCORE (p=0.505).
Conclusion: As a significant thinning of AD occurred following phenylephrine instillation, and as the magnitude of this thinning is related with SCORE, it is useful to test the retinal artery contraction to infer the cardiovascular health status.

Keywords: choroidal thickness, peripapillary choroidal thickness, retinal nerve fiber layer, phenylephrine

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