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Resveratrol as a potential therapeutic drug for respiratory system diseases

Authors Zhu X, Lei X, Dong W

Received 11 August 2017

Accepted for publication 14 November 2017

Published 15 December 2017 Volume 2017:11 Pages 3591—3598

DOI https://doi.org/10.2147/DDDT.S148868

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Frank Boeckler


Xiao-dan Zhu, Xiao-ping Lei, Wen-bin Dong

Department of Newborn Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China

Abstract:
Respiratory system diseases are common and major ailments that seriously endanger human health. Resveratrol, a polyphenolic phytoalexin, is considered an anti-inflammatory, antioxidant, and anticancer agent. Thanks to its wide range of biological activities, resveratrol has become a hotspot in many fields, including respiratory system diseases. Indeed, research has demonstrated that resveratrol is helpful to relieve pulmonary function in the general population. Meanwhile, growing evidence indicates that resveratrol plays a protective role in respiratory system diseases. This review aimed to summarize the main protective effects of resveratrol in respiratory system diseases, including its anti-inflammatory, antiapoptotic, antioxidant, antifibrotic, antihypertensive, and anticancer activities. We found that resveratrol plays a protective role in the respiratory system through a variety of mechanisms, and so it may become a new drug for the treatment of respiratory system diseases.

Keywords: respiratory system diseases, resveratrol, inflammation, apoptosis, oxidation

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