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Results of endocapsular phacofracture debulking of hard cataracts

Authors Davison J

Received 2 April 2015

Accepted for publication 4 May 2015

Published 10 July 2015 Volume 2015:9 Pages 1233—1238

DOI https://doi.org/10.2147/OPTH.S85939

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


James A Davison

Wolfe Eye Clinic, Marshalltown, IA, USA


Purpose/aim of the study: To present a phacoemulsification technique for hard cataracts and compare postoperative results using two different ultrasonic tip motions during quadrant removal.
Materials and methods: A phacoemulsification technique which employs in situ fracture and endocapsular debulking for hard cataracts is presented. The prospective study included 56 consecutive cases of hard cataract (LOCS III NC [Lens Opacification Classification System III, nuclear color], average 4.26), which were operated using the Infiniti machine and the Partial Kelman tip. Longitudinal tip movement was used for sculpting for all cases which were randomized to receive longitudinal or torsional/interjected longitudinal (Intelligent Phaco [IP]) strategies for quadrant removal. Measurements included cumulative dissipated energy (CDE), 3 months postoperative surgically induced astigmatism (SIA), and corneal endothelial cell density (ECD) losses.
Results: No complications were recorded in any of the cases. Respective overall and longitudinal vs IP means were as follows: CDE, 51.6±15.6 and 55.7±15.5 vs 48.6±15.1; SIA, 0.36±0.2 D and 0.4±0.2 D vs 0.3±0.2 D; and mean ECD loss, 4.1%±10.8% and 5.9%±13.4% vs 2.7%±7.8%. The differences between longitudinal and IP were not significant for any of the three categories.
Conclusion: The endocapsular phacofracture debulking technique is safe and effective for phacoemulsification of hard cataracts using longitudinal or torsional IP strategies for quadrant removal with the Infiniti machine and Partial Kelman tip.

Keywords: astigmatism, cataract, corneal endothelium, phacoemulsification, viscoelastic

Introduction

Two of the most commonly used strategies for phacoemulsification are in situ fracture and phaco chop. In situ fracture,1 ie, divide and conquer2 features low-vacuum sculpting of grooves in the nucleus, followed by fracturing the posterior nuclear plate, followed by the aspiration of usually four quadrants at higher vacuum and flow levels. In phaco chop,3 a varying number of sections are created by the chopping motion of a second instrument against the nucleus held by the phacoemulsification tip after it has burrowed into the central nucleus. Higher vacuum and flow are then used to aspirate the radially separated resultant segments.

More tip movement is required during sculpting with the in situ fracture technique, so machine-measured energy usage is always higher. However, the resultant quadrants are smaller, and space within the capsular bag will have been created during sculpting. This space can be utilized by allowing the quadrants to be pulled away from the posterior capsule and then aspirating them with high vacuum. Most of the technique can be accomplished within the capsular bag away from the corneal endothelium. Less tip movement is required with the phaco chop technique, so recorded energy expenditures are lower. But since there is no material removed during sculpting, the segments or quadrants may be larger. And since there is no created space available for centralization away from the posterior capsule, they (especially the initial ones) are usually pulled into the anterior chamber, away from the posterior capsule, but nearer to the corneal endothelium for safe removal.4

A mathematically estimated two-third nucleus volume reduction can be achieved by fracturing the nucleus into three pieces and then sculpting the nuclear walls.5 This relatively safe but energy-consuming nuclear volume reduction is particularly desirable during phacoemulsification of hard cataracts, where it is more difficult to protect both the posterior capsule and corneal endothelium.

This paper presents a hybrid variation6 of the in situ fracture technique, which incorporates further sculpting after posterior plate fracture, to achieve a debulking of four nuclear quadrants prior to their removal. It also presents a study of hard cataract case results using longitudinal vs IP (Intelligent Phaco) strategy for quadrant removal with the Alcon Infiniti machine and the Partial Kelman tip (Alcon Laboratories, Inc., Fort Worth, TX, USA).

Materials and methods

Endocapsular phacofracture debulking technique

Eyes were dilated with Cyclogyl 1% and NeoSynephrine 2.5%. Topical/intracameral anesthesia (preservative-free lidocaine 1%) was used for all cases. Irrigation was provided via a balanced salt solution (BSS) (Alcon Laboratories, Inc.). The irrigation solution was supplemented with epinephrine and vancomycin (both from Hospira, Lake Forest, IL, USA) to achieve final concentrations of .2 mg/L epinephrine and 60 mg/L vancomycin. All main incisions were 2.4 mm, temporal, and limbal near-clear. DuoVisc (Alcon Laboratories, Inc.) viscoelastic was injected using a soft-shell technique.7 Approximately 0.1 mL of the dispersive viscoelastic (Viscoat, Alcon Laboratories, Inc.; sodium hyaluronate 3% with chondroitin sulfate 4%) was injected under the cornea’s surface (approximately one-third fill of the anterior chamber). Then, approximately 0.2 mL of the cohesive viscoelastic (ProVisc, Alcon Laboratories, Inc.; 3% sodium hyaluronate) was injected underneath the Viscoat to cover the anterior lens capsule and to push the Viscoat forward to coat the corneal endothelium and complete the filling of the anterior chamber. Capsulorhexes, with an intended 5.0 mm diameter, were performed using a bent needle cystotome, and hydrodissection was accomplished using a disposable Chang cannula (4036J, Oasis Medical Inc., San Dimas, CA, USA).

Alcon Infiniti phacoemulsification machines were used with the following features: 0.9 mm outside diameter, 12° shaft angle (Partial Kelman), 45° aperture, ABS Mini-flare tip; MicroSmooth Ultra Infusion Sleeve; and fluid management system (FMS) tubing and cassette. Continuous longitudinal tip motion was used for sculpting and volume reduction for both groups. For quadrant removal, the continuous longitudinal strategy was used for one group, and torsional with interjected vacuum demand triggered bursts of longitudinal (Intelligent Phaco, IP) strategy was used for the other (Table 1).

Table 1 Ultrasonic energy and fluidic parameters for longitudinal and torsional (IP) quadrant removal
Notes: aContinuous longitudinal; bcontinuous IP with IP 90% vacuum trigger and 1:1 ratio and 0.7 seconds on time, with a minimum of 2 seconds continuous torsional prior to next activation.
Abbreviations: IP, Intelligent Phaco; AFR, aspiration flow rate.

Deep grooves were sculpted in the nucleus at right angles to each other, then, the posterior nuclear plate was torn bimanually. The tip was then turned obliquely and used to debulk the nucleus by removing the remaining corners of the quadrants, leaving a thin peripheral nuclear shell. During quadrant removal, the first quadrant is mobilized with higher vacuum, rolled centrally, and then emulsified while being contained within the nuclear shell (Figure 1AD). The remaining plates contain the central emulsification process and protect the posterior capsule, except for the last quadrant, which is held in a more anterior position with the tip aperture facing anterior (Figure 2AD). In the hardest cases, reinjection of Viscoat was accomplished before emulsification of the last quadrant to physically insulate the corneal endothelium and posterior capsule. Lens cortex was removed with a disposable silicone tip attached to an irrigation/aspiration handpiece, and the posterior capsule vacuumed with it as well.

Figure 1 Aspiration of first quadrant.
Notes: (A) In foot position 3 (FP 3), the obliquely oriented tip is shaving the firm corner off the fourth quadrant in the final step of debulking the nucleus and creating a thin nuclear bowl. Low vacuum at 50 mmHg and low flow at 14 cc/min prevent occlusion and inadvertent aspiration. (B) In FP 2, the obliquely oriented phaco tip aperture is poised in an access orientation to apply suction to the side of the first nuclear plate. Vacuum is starting to build and has reached 105 mmHg. (C) A tiny burst of low-power ultrasound has allowed the tip aperture to become occluded. Power has then been discontinued and vacuum has built to 368 mmHg and is providing good suction adherence. This allows the first nuclear plate to be rolled into the bowl, which is now partial as it is comprised of three remaining plates. The longer –1 rise time allows about 1 second to acquire and roll in the fragment before reaching maximum vacuum. (D) The nuclear fragment is held within the anterior central bowl by the nuclear plates, the phaco tip, and the cyclodialysis the custom 0.35 mm cyclodialysis spatula (SP765852, Baush + Lomb Stortz, Bridgewater, NJ, USA). Intermediate levels of vacuum, ultrasonic energy and flow simultaneously and in concert deform and emulsify the progressively smaller fragment while aspirating the emulsate.
Abbreviations: IP, Intelligent Phaco; CDE, cumulative dissipated energy; Irr, irrigation; Asp, aspiration; Vac, vacuum.

Figure 2 Emulsification and removal of subsequent nuclear plates.
Notes: (A) After the first quadrant has been aspirated, the cyclodialysis spatula is pushing on the peripheral edge of the fourth quadrant which easily rotates the second quadrant clockwise into its access position. (B) Flow of fluid has brought the fragment close to the tip aperture, and vacuum has reached 88 mmHg as the obliquely oriented aperture is acquiring the edge of the second plate. (C) Roll in centralization is assisted by the cyclodialysis spatula. It also then contains the plate’s position as it is being emulsified. The remaining two plates continue to form a partial bowl which creates a floor to insulate the posterior capsule from inadvertent aspiration. (D) The physical buffer of the nuclear bowl is gone as the fourth plate is being rolled into the iris plane for emulsification and removal. The cyclodialysis spatula helps manipulate and contain, but is mostly positioned under the phaco tip to protect the posterior capsule. Viscoelastic reinjection prior to this step pushes the posterior capsule back and insulates the corneal endothelium.
Abbreviations: IP, Intelligent Phaco; CDE, cumulative dissipated energy; Irr, irrigation; Asp, aspiration; Vac, vacuum.

After anterior chamber reinflation with ProVisc, a single piece acrylic intraocular lens (IOL, Alcon Laboratories, Inc.) was injected into the capsular bag using a Monarch III injector (Alcon Laboratories, Inc.) loaded with Viscoat. Viscoelastic was removed from beneath the IOL optic and from the anterior chamber, as much as was safely possible in each case. Stromal hydration and ocular pressurization were achieved with BSS through a 30-gauge cannula, and all incisions were verified as self-sealing by incision compression with triangular synthetic sponges until normal intraocular pressure was achieved.

Values for cumulative dissipated energy (CDE) were recorded from the display panel of the phacoemulsification machine. The manufacturer defines longitudinal and torsional phacoemulsification CDE, respectively, as (phacoemulsification time × average phacoemulsification power at the proximal shaft) and (torsional time ×0.4× average torsional amplitude at the proximal shaft).8 This equation contains assumptions – including directional differences of stroke length vs rotational degree excursion, the maximum tip-end amplitude, and the frequency differences of the two modes (40 kHz in longitudinal mode and 32 kHz in torsional mode) – that resulted in the 0.4 multiplier (personal communication, Alcon Surgical, 2010). Intraoperative complications were recorded on the operation note at the time of surgery.

Study of longitudinal vs IP in quadrant removal results

The randomized prospective study presents a series of consecutive cases operated by the author in 2011. Randomization was accomplished using a table with even and odd numbers prior to the start of surgery. The study received Institutional Review Committee approval, and all patients signed appropriate informed consent. Inclusion criteria included diagnosis of cataract with Lens Opacification Classification System III, nuclear color (LOCS III NC)9 grade of 3.8–5.1. Exclusion criteria included corneal endothelial dystrophy, pseudoexfoliation, history of trauma or iritis, or previous eye surgery. Corneal endothelial cell photographs were taken and central corneal endothelial cell densities (ECDs) determined using a 100-cell standardized counting technique with a noncontact specular microscope camera (Konan SP9000, Hyogo, Japan). IOL calculations were accomplished using the IOLMaster, version 5 (Zeiss Humphrey, Carl Zeiss Meditec AG, Jena, Germany), for axial length and keratometry determinations. ECD photographs and keratometry measurement by IOLMaster were accomplished 3 months after surgery for comparison.

Mean CDEs and preoperative vs postoperative measurements for mean ECD and automated keratometry changes were compared. A two-sample t-test, baseline-adjusted analysis of covariance (ANCOVA), t-test on changes from baseline, and t-test on percentage change from baseline were used to compare group ECD changes. Surgically induced astigmatism (SIA) was calculated using IOLMaster measurements in a proprietary formula derived by Warren Hill, MD (available at http://www.doctor-hill.com/physicians/download.htm). The Wilcoxon rank sum test was applied to keratometric data. Statistical testing was accomplished by an independent statistician.

Results

There were no complications, including anterior radial capsular tears, noted in any of the cases of both groups.

A total of 56 cases had adequate pre- and postoperative endothelial cell photographs. Table 2 shows group similarities for age and LOCS III NC grading. Table 3 shows respective overall and longitudinal vs IP means for CDE, ECD loss, and SIA. The differences between longitudinal and IP were not significant for any of the three categories.

Table 2 Preoperative and intraoperative case characteristics
Abbreviations: NC, LOCS III nuclear color; IP, Intelligent Phaco.

Table 3 Postoperative results for ECD loss and SIA
Note: *P>0.05.
Abbreviations: ECD, endothelial cell density; SIA, surgically induced astigmatism; CDE, cumulative dissipated energy; D, diopter; IP, Intelligent Phaco.

Machine-measured CDE correlated with LOCS III NC rating for both longitudinal and IP groups, respectively (coefficient: 0.64, P=0.0011 and 0.77, P<0.0001). There was no correlation of CDE to ECD loss for either longitudinal or IP groups (coefficient: −0.31, P=0.1939 and −0.45, P=0.0673).

Discussion

Modern techniques and high-performance machines have combined to produce innumerable effective strategies for phacoemulsification with somewhat different but comparatively similar results. Increased cutting efficiency with lower CDE measurement has been achieved with 22° (Kelman) vs 12° (Partial Kelman) distal shaft angles and 45° vs 30° tip aperture angles10,11 because of relatively greater tip movement at the aperture edge vs the shaft, where CDE is defined and measured. Aspiration efficiency has also been improved with torsional tip motion, especially with the Partial Kelman tip vs the straight tip, because of the reduction in repulsion and increased followability of nuclear material.12 However, similar corneal ECD losses have been reported with longitudinal motions of straight tips (7.1%) and torsional tip motions of Kelman tips (7.2%).13 Regardless of equipment or tip movement strategy, the task becomes increasingly difficult in harder cataracts. Higher ultrasonic energy expenditure is correlated with increasing LOCS III NC values14 and increased corneal ECD losses occur as cataract hardness increases.15 These hard cases require more exacting control and the exercise of substantial patience on the part of the surgeon in order to be accomplished effectively.

Phaco chop is popular because of its efficiency and has been shown to be effective in normal density cataracts. But in that strategy, larger nuclear fragments are drawn forward and emulsified in the anterior chamber which might possibly lead to increased corneal ECD losses.4 In one study using Viscoat and phaco chop on cataracts grade 1–4 with LOCS II, there was an association with moderate corneal ECD losses in both longitudinal (19.1%) and torsional (12.5%) tip movement strategies in very experienced hands, even while using Viscoat to protect the corneal endothelium.16 But in another with a subset of cases comprising harder cataracts (average LOCS III NO [nuclear opalescence] 4.0), phaco chop has more recently been shown to result in lower ECD losses (5.2%) vs stop and chop (7.2%) and divide and conquer (9.1%).17 Viscoat was not used in cases of that study, and there were no differences in ECD losses between techniques in the removal of softer cataracts (NO 2 and NO 3).

The endocapsular phacofracture debulking technique described herein allows the surgeon to shave away hard nuclear material with low vacuum and low aspiration flow rate parameters, and then emulsify and aspirate relatively thin peripheral plates with higher vacuum and flow. The principles of the technique actually work with all grades of cataract. The softer the nucleus, the more the anterior material should be left to control the pace of acquisition, depth of tip burrowing, projection of vacuum and flow, and speed to roll the quadrants into the central space for aspiration. The amount of nuclear material which can be removed is difficult to estimate, but a geometric calculation using a similar technique which leaves three remaining fragments demonstrated a 69% possible reduction in nucleus volume prior to fragment mobilization.5 The quadrant shaving technique described herein may allow even greater nuclear volume reduction.

Regardless of absolute size of the remaining plates, when they are mobilized centrally, they are thinner, more manageable, and less likely to bump up against the iris and corneal endothelium as they are removed. With the aspiration of each plate, the remaining ones are rotated to form a physical insulator, which protects the posterior capsule and helps contain the process by stabilizing the plate which was being emulsified. The last plate does not have the advantage of that insulation, and in order to stay away from the posterior capsule, is always removed in a more anterior location within the iris plane and anterior chamber. For this reason, the last plate to be removed should be a smaller one, and if it is hard, Viscoat reinjection should be considered.

Especially important with hard cataracts, Viscoat and its reinjection prior to removal of the last quadrant contributes greatly to the physical insulation of the corneal endothelium from nuclear fragment abrasion and acoustic energy transmission and absorption associated with the emulsification process.18,19 Corneal endothelial cell losses as low as 1.2% continue to be reported while using Viscoat during phacoemulsification.20 This dispersive viscoelastic is no doubt critical to the low cell losses reported in this paper. When it is not used, even with adjunctive femtosecond laser nucleus dissection and very little phacoemulsification energy, ECD losses have been shown to be as high as 12.1%.21,22

Although different, the ECD changes in this study were not statistically significantly different whether using torsional IP or longitudinal tip motion during quadrant removal. Reasons for this lack of difference could be small sample sizes, the fact that the losses were both so low that a significant difference was more difficult to identify, or that most of the phacoemulsification energy was expended in longitudinal mode during sculpting for both groups. The main point is that, given the study of hard cataracts, corneal endothelial cell losses were low with this technique regardless of tip motion in quadrant removal.

The machine-measured CDE may be higher with this technique vs phaco chop because of the time and energy required during sculpting and aspiration of nuclear emulsate during low-vacuum volume reduction. But the acoustic energy created by the vibrating tip during that process is essentially endocapsular and well away from the corneal endothelium, making the CDE less relevant to the prediction of corneal endothelial health after surgery. Using the debulking technique described here, added forgiveness is enjoyed during the more demanding high-vacuum aspiration phase of surgery because the remaining thin nuclear plates require less manipulation, less time to manipulate, and smaller amounts of ultrasonic energy to remove in a largely endocapsular process well away from the corneal endothelium.

Disclosure

Dr Davison is a paid consultant to Alcon, but has no financial or proprietary interest in any material or method mentioned in this manuscript.


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