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Resting-state magnetoencephalography study of “small world” characteristics and cognitive dysfunction in patients with glioma

Authors Hu X, Lei T, Xu, Zou, Liu

Received 7 January 2013

Accepted for publication 25 February 2013

Published 3 April 2013 Volume 2013:6 Pages 311—313

DOI https://doi.org/10.2147/OTT.S42471

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2


Xin-Hua Hu, Ting Lei, Hua-Zhong Xu, Yuan-Jie Zou, Hong-Yi Liu

Department of Neurosurgery, Brain Hospital Affiliated to Nanjing Medical University, Nanjing, People's Republic of China

Background: The purpose of this study was to analyze “small world” characteristics in glioma patients in order to understand the relationship between cognitive dysfunction and brain functional connectivity network in the resting state.
Methods: Resting-state magnetoencephalography was performed in 20 patients with glioma and 20 healthy subjects. The clustering coefficient of the resting functional connectivity network in the brain, average path length, and “small world” index (SWI) were calculated. Cognitive function was estimated by testing of attention, verbal fluency, memory, athletic ability, visual-spatial ability, and intelligence.
Results: Compared with healthy controls, patients with glioma showed decreased cognitive function, and diminished low and high gamma band “small world” characteristics in the resting functional connectivity network.
Conclusion: The SWI is associated with cognitive function and is diminished in patients with glioma, and is therefore correlated with cognition dysfunction.

Keywords: glioma, cognitive dysfunction, “small world”, functional connectivity network, magnetoencephalography

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