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Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD

Authors Li G, Rossbach K, Zhang A, Liu P, Zhang K

Received 13 March 2018

Accepted for publication 21 May 2018

Published 7 August 2018 Volume 2018:14 Pages 1991—1998

DOI https://doi.org/10.2147/NDT.S168060

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Professor Wai Kwong Tang


Gaizhi Li,1 Kathryn Rossbach,2 Aixia Zhang,1 Penghong Liu,1 Kerang Zhang1

1Shanxi Medical University, Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China; 2Independent researcher, Atlanta, GA, USA

Background: Major depressive disorder (MDD) is a leading psychiatric disorder that has a lack of biomarkers for a diagnosis.
Purpose: The objective of this study was to examine the structural and functional change in the precuneus within first-episode drug naive patients with MDD.
Methods: Thirty-two first episode drug-naive patients with MDD and thirty healthy controls (HCs) were recruited in this study; the structural MRI and fMRI data were collected using the 3.0 T Trio Siemens System. All the patients were interviewed using the HAMD-17.
Results: The difference between gray matter volume within the two groups was not observed. Results indicated that the low-frequency fluctuations (ALFF), fractional ALFF (fALFF) and regional homogeneity values of the precuneus within first-episode drug-naive patients with MDD were lower than the HCs. In addition, the fALFF value of the MDD was negatively and statistically significantly correlated with the HAMD-17 total score (P<0.05).
Conclusion: The current study found abnormal activity of the precuneus at resting state in first-episode drug-naive patients with MDD, indicating that activity within the precuneus may be a potential biomarker for the diagnosis of MDD.

Keywords: major depressive disorder, resting-state fMRI, precuneus

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