Back to Journals » Clinical Interventions in Aging » Volume 8
Response to Alzheimer’s research paper
Authors Tait HM
Received 1 March 2013
Accepted for publication 2 March 2013
Published 8 May 2013 Volume 2013:8 Pages 495—499
DOI https://doi.org/10.2147/CIA.S44638
Checked for plagiarism Yes
H Mina Tait
Department of Biomedical Science, The University of Sheffield, Sheffield, UK
Zhang et al have recently published an interesting article in Clinical Interventions in Aging entitled “Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid β1-42-induced rat model of Alzheimer’s disease”.1 The conclusion that “IL-1β, IL-6, and TNF-α were significantly decreased in the atorvastatin-treated AD group than that in the AD group” is not justified by the data presented in Figures 1, 2, and 3. Given that the AD group and the atorvastatin-treated AD group showed no significant difference in numbers of cells positive for interleukin-1β, interleukin-6, or tumor necrosis factor-α, and in some cases there may be a trend towards an increase in positive cells in the atorvastatin-treated AD group, it is hard to see how they came to this conclusion.
View original paper by Zhang and colleagues.
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