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Hepatocellular Carcinoma with Portal Vein Tumor Thrombus versus Hepatocellular Carcinoma with Biliary Tumor Thrombus: Better or Worse Prognoses? [Response to Letter]

Authors Yang X, Zhu Y, Zhao X, Li JH, Xu D, Jia HL, Zhang J

Received 27 January 2021

Accepted for publication 27 January 2021

Published 11 February 2021 Volume 2021:13 Pages 1323—1324


Xin Yang,1,* Ying Zhu,1,* Xia Zhao,2,* Jian-Hua Li,1,* Da Xu,1 Hu-Liang Jia,1 Jubo Zhang3

1Department of General Surgery, Huashan Hospital & Cancer Metastasis Institute, Fudan University, Shanghai, People’s Republic of China; 2Health Management Center, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 3Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Jubo Zhang
Department of Infectious Diseases, Huashan Hospital, Fudan University, 12 Urumqi Road (M), Shanghai, 200040, People’s Republic of China
Tel +86-21-52887170
Hu-Liang Jia
Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai, 200040, People’s Republic of China
Tel +86-21-52887175

First of all, we would like to thank Professor Chen from the Eastern Hepatobiliary Hospital for his comments. Professor Chen has put forward a lot of views and references for us, which will be the direction and focus of our future work. The prevalence, clinical characteristics, and oncology results of HCC patients with PVTT and BDTT vary greatly. Therefore, it is necessary to explore the prognosis of HCC patients with different types of tumor thrombosis to guide the treatment of patients. Although we have
received more patients with liver cancer combined with tumor thrombi, fewer patients are truly eligible for surgery, especially those with bile duct tumor thrombi. This is also the main reason for our small sample size. Of course, a small sample may lead to one-sided conclusions, which may only be for reference. In Table 3, because there are a large number of PVTT patients, and PVTT is habitually placed first. In fact, high-risk one (BDTT) should be placed first, and it should be BDTT verse PVTT. We are very
sorry, this is a small mistake in our writing, which caused misunderstanding. According to the literature data provided by Professor
Chen, the prognosis of BDTT patients does not seem to be inferior to that of PVTT patients. For a correct conclusion, it may require larger sample sizes and more retrospective studies from more centers at home and abroad. Collecting more clinical data may be more helpful for drawing correct conclusions. According to Professor Chen’s suggestions, we will collect more comprehensive clinical data for research in the future. Finally, we hope that more scholars will pay attention to and conduct research on liver cancer combined with tumor thrombi to improve the prognosis of these patients.

View the original paper by Yang and colleagues
This is in response to the Letter to the Editor

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