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Repeated renal infarction in native and transplanted kidneys due to left ventricular thrombus formation caused by antiphospholipid antibody syndrome

Authors Scully P, Leckstroem D, McGrath A, Chambers J, Goldsmith D

Received 18 October 2012

Accepted for publication 13 November 2012

Published 20 January 2013 Volume 2013:6 Pages 7—12


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 5

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Video abstract presented by Daniel Leckstroem and David Goldsmith

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Paul Scully,1 Daniel C Leckstroem,1 Andrew McGrath,2 John Chambers,3 David J Goldsmith1

1Nephrology Department, 2Radiology Department, 3Cardiology Department, King's Health Partners, Academic Health Sciences Centre, London, United Kingdom

Abstract: Antiphospholipid syndrome can be a feature of several underlying conditions, such as lupus, but it can also occur idiopathically. Diagnosis usually comes after investigation of recurrent venous or arterial thromboses, emboli, or hypertension/proteinuria where the kidney is involved and is usually confirmed by laboratory testing. We describe a case of a man with a myocardial infarction who developed mural thrombus in an akinetic left ventricular segment but then who recurrently embolized first to one of his native kidneys and then later to a transplanted kidney. Although the clinical behavior was typical of antiphospholipid syndrome, it took numerous laboratory assays over many years until finally the problem was confirmed and life-long warfarin therapy instituted.

Keywords: antiphospholipid therapy, emboli, infarction, kidney, kidney transplant

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