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Relationship Between Structure And Antimicrobial Activity Of Zinc Oxide Nanoparticles: An Overview

Authors Lallo da Silva B, Abuçafy MP, Berbel Manaia E, Oshiro Junior JA, Chiari-Andréo BG, Pietro RCLR, Chiavacci LA

Received 18 May 2019

Accepted for publication 28 August 2019

Published 2 December 2019 Volume 2019:14 Pages 9395—9410

DOI https://doi.org/10.2147/IJN.S216204

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Anderson Oliveira Lobo


Bruna Lallo da Silva,1 Marina Paiva Abuçafy,1 Eloisa Berbel Manaia,1 João Augusto Oshiro Junior,1 Bruna Galdorfini Chiari-Andréo,1,2 Rosemeire CL R Pietro,1 Leila Aparecida Chiavacci1

1Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, SP, Brazil; 2Department of Biological and Health Sciences, Universidade De Araraquara, UNIARA, Araraquara, SP, Brazil

Correspondence: Leila Aparecida Chiavacci
Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara Jaú, km 1 – s/n Campos Ville, Araraquara, SP, Brazil
Tel +55 16 33016966
Fax +55 16 33016900
Email leila@fcfar.unesp.br

Abstract: The inappropriate use of antimicrobials has resulted in the selection of resistant strains. Thus, a great number of studies have focused on the investigation of new antimicrobial agents. The use of zinc oxide nanoparticles (ZnO NPs) to optimise the fight against microbial resistance has been receiving increased attention due to the non-specific activity of inorganic antimicrobial agents. The small particle size and the high surface area of ZnO NPs can enhance antimicrobial activity, causing an improvement in surface reactivity. In addition, surface modifiers covering ZnO NPs can play a role in mediating antimicrobial activity since the surface properties of nanomaterials alter their interactions with cells; this may interfere with the antimicrobial effect of ZnO NPs. The possibility of using surface modifiers with groups toxic to microorganisms can improve the antimicrobial activity of ZnO NPs. Understanding the exact toxicity mechanisms is crucial to elucidating the antimicrobial activity of ZnO NPs in bacteria and fungi. Therefore, this review aims to describe the mechanisms of ZnO NPs toxicity against fungi and bacteria and how the different structural and physical-chemical characteristics of ZnO NPs can interfere in their antimicrobial activity.

Keywords: nanoparticles, zinc oxide, antimicrobial activity, toxicity mechanisms

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