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Relationship between airway obstruction and incidence of metabolic syndrome in Korea: a community-based cohort study

Authors Kim CY, Park Y, Leem AY, Chung KS, Jung JY, Park MS, Kim YS

Received 18 November 2017

Accepted for publication 13 February 2018

Published 28 June 2018 Volume 2018:13 Pages 2057—2063

DOI https://doi.org/10.2147/COPD.S157453

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Charles Downs

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell


Chi Young Kim, Youngmok Park, Ah Young Leem, Kyung Soo Chung, Ji Ye Jung, Moo Suk Park, Young Sam Kim

Division of Pulmonology, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea

Background: Although studies have examined the relationship between metabolic syndrome (MetS) and COPD, the incidence of MetS in individuals with COPD has not specifically been investigated. This study aimed to evaluate the incidence of MetS in subjects with airway obstruction using data from a community-based cohort.
Patients and methods: Data representing 4 years of follow-up from the Ansung–Ansan cohort were analyzed; a total of 6,184 adults, who were ≥40 years of age and underwent spirometry, were enrolled in this study. Airway obstruction was defined as forced expiratory volume in 1 s/forced vital capacity ratio <70%, and MetS was determined according to the National Cholesterol Education Program Adult Treatment Panel III guidelines.
Results: A total of 419 patients were newly diagnosed with MetS, based on the National Cholesterol Education Program Adult Treatment Panel III guidelines, during follow-up. MetS was more frequent in COPD subjects, relative to non-COPD subjects, in both sexes (14.7% vs 11.0% [men] and 14.7% vs 11.8% [women]). In men subjects, the risk for MetS was higher in subjects with airflow obstruction than in subjects without obstruction, after adjusting for age, body mass index, and smoking status.
Conclusion: The incidence of MetS was higher in men with airflow obstruction than in healthy subjects.

Keywords: COPD, metabolic syndrome, incidence

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