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Recent advances in host–virus interactomics during entry and infection

Authors Bhattacharjee S

Received 30 June 2015

Accepted for publication 29 September 2015

Published 1 December 2015 Volume 2015:7 Pages 57—66

DOI https://doi.org/10.2147/VAAT.S60265

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Malathi Krishnamurthy

Peer reviewer comments 2

Editor who approved publication: Professor Jonathan Dinman

Soumen Bhattacharjee

Cell and Molecular Biology Laboratory, Department of Zoology, University of North Bengal, Siliguri, Darjeeling, West Bengal, India

Abstract: Viral infections and pandemics result in millions of deaths worldwide each year. Viruses exploit host cellular processes, not only to gain entry and to deliver their genetic cargo, but also to counteract and use host immune defenses. To this end, a variety of ingenious strategies have evolved in viruses that involve fusion between virus and host membranes, channel formation through the host plasma membranes, disruption of the membrane vesicles, or a combination of these events. The entry and infection pathways of virus are thus largely defined by the interactions between virus particles and their cell surface and cytoplasmic receptors. A thorough analysis of virus–host interactomes may reveal novel mechanisms in virus entry, virus infection, and pathogenic strategies to modulate host metabolic pathways. The study of viral entry, infection, and pathogenesis has evolved over a long period. A host of next-generation technological advancements in this field has been discussed in this review.

Keywords: RNA interference, high-throughput, bioinformatics, viral entry, viral infection, virus–host interactions

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