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Rationale for multiple risk intervention: The need to move from theory to practice

Authors Leif R Erhardt

Published 15 January 2008 Volume 2007:3(6) Pages 985—997

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Leif R Erhardt

Department of Clinical Sciences, Medicine, Lund University, Malmö University Hospital, Malmö, Sweden

Abstract: Incidence of cardiovascular (CV) and metabolic disease is increasing, in parallel with associated risk factors. These factors, such as low-density lipoprotein (LDL)-cholesterol, elevated blood pressure, obesity, and insulin resistance have a continuous, progressive impact on total CV risk, with higher levels and numbers of factors translating into greater risk. Evaluation of all known modifiable risk factors, to provide a detailed total CV disease (CVD) and metabolic risk-status profile is therefore necessary to ensure appropriate treatment of each factor within the context of a multifactorial, global approach to prevention of CVD and metabolic disease. Effective and well-tolerated pharmacotherapies are available for the treatment of risk-factors. Realization of the potential health and economic benefits of effective risk factor management requires improved risk factor screening, early and aggressive treatment, improved public health support (ie, education and guidelines), and appropriate therapeutic interventions based on current guidelines and accurate risk assessment. Patient compliance and persistence to available therapies is also necessary for successful modulation of CVD risk.

Keywords: cardiovascular disease, risk factors, risk factor management, metabolic syndrome, blood pressure, obesity, hyperlipidemia, insulin resistance, new-onset diabetes, implementation

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