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Quick reference guide to apixaban

Authors Hurst KV, O'Callaghan JM, Handa A

Received 9 September 2016

Accepted for publication 10 January 2017

Published 10 July 2017 Volume 2017:13 Pages 263—267


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Daniel A. Duprez

Katherine Victoria Hurst, John Matthew O’Callaghan, Ashok Handa

Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK

Abstract: Direct oral anticoagulants (DOACs) are being increasingly used in the clinical setting for patients at risk of venous thromboembolism (VTE) and/or stroke. These medications offer valued benefits for long-term use, including a fast onset of anticoagulation, fixed anticoagulation profile (and consequent prescription of specified doses) and no requirement for routine monitoring. Apixaban is a selective factor Xa inhibitor, approved for use in the prevention of stroke in patients with nonvalvular atrial fibrillation and in the prevention and treatment of acute VTE. Like many of the DOACs, it has a fast onset of action and works to deliver predictable coagulation results. Multiple randomized controlled trials including ARISTOTLE and AMPLIFY have shown apixaban to be noninferior to vitamin K antagonists in the prevention of stroke and VTE, with a good safety profile. This article aims to review the use of apixaban for the prevention and treatment of thromboembolic disease, highlighting the key study results that have led to its current licensing and use.

Keywords: apixaban, stroke management, venous thromboembolism

Corrigendum for this paper has been published

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