Dr Naduparambil K. Jacob

Dr Naduparambil K. Jacob

Dr. Jacob is an Assistant Professor of Radiation Oncology at The Ohio State University (OSU) Wexner Medical Center, USA. He is a member of translational therapeutics program at the OSU Comprehensive Cancer Center (OSUCCC). He received PhD in Biology from University of Tuebingen, Germany and completed his postdoctoral training at University of Cincinnati College of Medicine, USA. Dr. Jacob's postdoctoral studies have contributed significantly to our current understanding of DNA structure at chromosome ends, particularly the biochemistry of generation of chromosome ends, resolving the structure of telomere chromatin at the molecular level. His laboratory at OSUCCC studies mechanism of radiation resistance in aggressive tumors and cancer metastasis. His research group uses rodent models for mechanistic studies and specimens from patients who received radiation therapy for correlative studies. His recent research led to the development of miRNA based radiation biodosimetry, which resulted in high impact publications, patents and secured research funding from US National Institutes of Health (NIH), Department of Defense (DOD) and National Aeronautics and Space Administration (NASA). Current research projects include developing miRNAs and long non-coding RNAs as biomarkers of normal tissue toxicity, tumor and organ specific responses, early prediction of delayed/late effects such as pneumonitis and fibrosis in patients receiving radiation therapy and also in victims of radiation accidents. Dr. Jacob has served in various grant review panels and editorial boards of multiple journals and is active in educational activities at the institutional and national level.  

Updated 12 April 2023