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Psychiatric comorbidities in patients with intentional methanol intoxication

Authors Yang WS, Yen TH, Juang YY, Lee SH, Wang BH, Lee CP

Received 31 October 2018

Accepted for publication 4 January 2019

Published 31 January 2019 Volume 2019:15 Pages 397—402

DOI https://doi.org/10.2147/NDT.S192943

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Yu-Ping Ning


Wei-Sheng Yang,1,2 Tzung-Hai Yen,2,3 Yeong-Yuh Juang,4 Shwu-Hua Lee,1,2 Bi-Hwa Wang,5 Chin-Pang Lee1,2

1Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; 2School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Department of Nephrology and Clinical Poison Center, Chang Gung Memorial Hospital, Linkou, Taiwan; 4Department of Psychiatry, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan; 5School of Nursing, College of Medicine, Chang Gung University, Taoyuan, Taiwan

Background: Intentional methanol intoxication (IMI) is an emerging public health issue in Asian countries, but few data are available in the literature on underlying psychiatric comorbidities in these suicide attempters.
Patients and methods: We conducted a retrospective chart review on patients with methanol intoxication (MI) treated at Chang-Gung Memorial Hospital, Linkou, Taiwan during 2000–2016. Of the 56 cases of documented MI, 16 were IMI. Baseline demographic, clinical, laboratory, psychiatric diagnoses, and mortality data were collected and analyzed.
Results: Patient group with IMI had more females (62.5% vs 7.5%, P=0.000), less alcohol consumption (33.3% vs 92.5%, P=0.000), and less smoking (40.0% vs 79.5%, P=0.009), but higher past psychiatric disease (73.3% vs 10.0%, P=0.000) and past suicide attempts (81.1% vs 2.5%, P=0.000) than patient group with unintentional MI (UMI). Pesticides (50.0%) comprised the most common source used for suicide, followed by industrial methanol (37.5%). There was no significant difference in mortality rates between these two group (25.0% vs 22.5%, P=0.548). Twelve (75.0%) survivors of IMI were referred to a psychiatric consultation-liaison team, and depressive disorder (58.3%) and adjustment disorder (25.0%) were common.
Conclusion: There is a female predominance and a high prevalence of psychiatric comorbidities, namely depression and adjustment disorder in patients with IMI. Besides, alcohol consumption is a prevalent but not adequately treated condition in UMI group.

Keywords: alcohol, suicide, methanol intoxication, pesticide, depression

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