Back to Journals » Journal of Pain Research » Volume 11

Psychiatric and physical comorbidities and pain in patients with multiple sclerosis

Authors Scherder R, Kant N, Wolf ET, Pijnenburg B, Scherder EJA

Received 18 July 2017

Accepted for publication 25 October 2017

Published 13 February 2018 Volume 2018:11 Pages 325—334

DOI https://doi.org/10.2147/JPR.S146717

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr E. Alfonso Romero-Sandoval


Rogier Scherder,1 Neeltje Kant,2 Evelien T Wolf,3 Bas Pijnenburg,4 Erik JA Scherder3

1Department of Orthopedics, Westfries Gasthuis, Hoorn, 2Department of Neuropsychology, Reade, Amsterdam, 3Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, 4Acibadem International Medical Center, Amsterdam, the Netherlands

Background: It has been observed that patients with multiple sclerosis (MS), who have psychiatric and physical comorbidities such as depression and COPD, have an increased risk of experiencing more pain. In this study, we have distinguished between pain intensity and pain affect, as the latter, particularly, requires treatment. Furthermore, while pain and comorbidities have been assessed using questionnaires, this is possibly a less reliable method for those who are cognitively vulnerable.
Objective: The aim of this study was to determine whether psychiatric and physical comorbidities can predict pain intensity and pain affect in MS patients, susceptible to cognitive impairment.
Methods: Ninety-four patients with MS and 80 control participants participated in this cross-sectional study. Besides depression and anxiety, 47 additional comorbidities were extracted from patients’ medical records. Depression and anxiety were assessed using the Beck Depression Inventory and the Symptom Check List-90. Pain was assessed using the Number of Words Chosen Affective, Coloured Analog Scale, and the Faces Pain Scale. Cognitive functions, for example, memory and executive functions, were assessed using several neuropsychological tests.
Results: The main findings indicate that psychiatric comorbidities (depression and anxiety) predict both pain intensity and pain affect and that total physical comorbidity predicts only pain affect in MS patients, susceptible to cognitive impairment.
Conclusion: Both psychiatric and physical comorbidities predict pain affect. All three clinical outcomes enhance MS patients’ suffering.

Keywords: multiple sclerosis, pain, comorbidities, mood, cognition

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]