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Psoriasis and comorbidities: links and risks

Authors Ni C, Chiu M

Received 3 January 2014

Accepted for publication 19 February 2014

Published 17 April 2014 Volume 2014:7 Pages 119—132

DOI https://doi.org/10.2147/CCID.S44843

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

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Catherine Ni, Melvin W Chiu

Division of Dermatology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA

Abstract: Psoriasis is a chronic inflammatory skin disease affecting approximately 2% of the population worldwide. In the past decade, many studies have drawn attention to comorbid conditions in psoriasis. This literature review examines the epidemiological evidence, pathophysiological commonalities, and therapeutic implications for different comorbidities of psoriasis. Cardiovascular disease, obesity, diabetes, hypertension, dyslipidemia, metabolic syndrome, nonalcoholic fatty liver disease, cancer, anxiety and depression, and inflammatory bowel disease have been found at a higher prevalence in psoriasis patients compared to the general population. Because of the wide range of comorbid conditions associated with psoriasis, comprehensive screening and treatment must be implemented to most effectively manage psoriasis patients.

Keywords: cardiovascular, metabolic syndrome


Introduction

Psoriasis is a chronic inflammatory skin disease with a complex etiology involving genetic and environmental factors. The relationship between psoriasis and other diseases has drawn increasing interest in recent years. Growing evidence suggests that cardiovascular disease, obesity, diabetes, hypertension, dyslipidemia, metabolic syndrome, nonalcoholic fatty liver disease (NAFLD), cancer, anxiety and depression, and inflammatory bowel disease are found at a higher prevalence in psoriasis patients compared to the general population.1 These disease associations may be due to the systemic inflammatory mediators generated in psoriasis, shared risk factors (ie, smoking, alcohol consumption), or treatment.

Early detection and treatment of the many comorbid conditions associated with psoriasis is important. An integrated approach should be taken to ensure that treatment of psoriasis does not interfere with the management of comorbid conditions and vice versa.

Cardiovascular disease and risk factors

Introduction and pathophysiology

There has been increasing awareness of the link between psoriasis, cardiovascular risk factors (hypertension, type 2 diabetes, dyslipidemia, metabolic syndrome), and cardiovascular disease. Patients with severe psoriasis were found to have a 5-year shorter life expectancy, with cardiovascular disease contributing significantly to this discrepancy.2 When cardiovascular risk factors were adjusted for, psoriasis patients still had an increased risk of stroke, atherosclerosis, myocardial infarction (MI), coronary artery disease (CAD), and endothelial dysfunction.2

Psoriasis, along with other chronic inflammatory systemic diseases, such as rheumatoid arthritis and systemic lupus erythematosus, may be linked to increased cardiovascular disease risk because of common pathogenic mechanisms.3 Inflammatory cells and proinflammatory cytokines contribute both to the development of psoriatic lesions and to the breakdown of atherosclerotic plaques.3 Psoriasis and atherosclerosis share a common pattern of Th1 and Th17 cytokine upregulation, T-cell activation, and local and systemic expression of adhesion molecules and endothelins.3 Activated T-cells near areas of inflammation produce type 1 cytokines such as interferon (IFN)-alpha, interleukin (IL)-2, and tumor necrosis factor (TNF)-alpha. IFN-alpha inhibits apoptosis, thus contributing to the hyperproliferation of keratinocytes. IL-2 stimulates T-cell proliferation.3,4

TNF-alpha is an inflammatory cytokine that is involved in the pathogenesis of both psoriasis and atherosclerosis. In psoriasis, TNF-alpha activates and increases keratinocyte proliferation. TNF-alpha has also been found to induce neutrophil chemotaxis, macrophage cytokine and chemokine production, and superoxide production, which can result in endothelial inflammation and dysfunction.5,6

C-reactive protein (CRP) is a marker of systemic inflammation that has been associated with atherosclerosis and cardiovascular disease. Elevated CRP is a result of interactions between proinflammatory cytokines IL-6, IL-1, and TNF-alpha.7 CRP is elevated with cardiovascular risk factors such as smoking, obesity, and diabetes.8 Multiple studies have shown that CRP can be used as a predictor of the risk of adverse cardiovascular events in both healthy individuals and those with a previous history of MI. Patients with psoriasis have been shown to have higher baseline levels of CRP than healthy controls in two studies (P<0.004 and P<0.001).9,10 In another study, CRP levels were found to correlate with the severity of disease.11 Patients with mild and severe psoriasis had higher levels of CRP when compared with controls (mean ± standard deviation: 0.31±0.02 mg/dL versus 0.90±0.27 mg/dL; P<0.001).11 Furthermore, patients with severe psoriasis had higher levels of CRP than those with mild psoriasis (mean ± standard deviation: 1.16±0.07 versus 0.63±0.03 mg/dL).11

Another possible mechanism of atherosclerosis-associated psoriasis is the production of vascular endothelial growth factor (VEGF) produced by keratinocytes, which are increased in psoriasis.1214 VEGF is a mitogen for endothelial cells and has been linked to intimal hyperplasia. VEGF is also positively associated with the severity of psoriasis and increased intimal media thickness (IMT).1214

As rapid skin turnover and increased keratinocyte activity occur in psoriasis, folate is consumed excessively in order to methylate DNA of rapidly dividing cells.15 Psoriasis patients have been found to have lower folate and, subsequently, higher homocysteine levels than normal controls.15,16 Hyperhomocysteinemia is an independent risk factor for cardiovascular disease, peripheral vascular disease, and cerebrovascular disease.17,18 High levels of homocysteine damage endothelial cells, promote clot formation, decrease blood vessel flexibility, and thus increase aortic stiffness.18 Elevated homocysteine may be yet another aspect of psoriasis that contributes to the increased risk of cardiovascular disease;15 however, the data on whether or not higher homocysteine levels correspond to the severity of psoriasis are conflicting.16,19,20

Scientific evidence

In a cohort study, patients with severe psoriasis (n=3,603) were found to have a greater absolute risk for major cardiac events (MI, stroke, and cardiovascular mortality) compared with normal controls (n=14,330).2 The frequency of major cardiac events was higher in psoriasis patients (4.9% versus 2.9%; P<0.01).2 After adjusting for cardiovascular risk factors, severe psoriasis was still a risk factor for major adverse cardiac events (hazard ratio [HR] 1.53; 95% confidence interval [CI]: 1.26–1.85).2 Furthermore, severe psoriasis was found to confer an additional 6.2% attributable risk on a 10-year incidence of major adverse cardiac events.2

A systematic review and meta-analysis reviewed cardiovascular risk in patients with mild (n=201,239) and severe (n=17,415) psoriasis.21

Mild psoriasis was associated with a significantly increased risk of MI (relative risk [RR] 1.29; 95% CI: 1.02–1.63) and stroke (RR 1.12; 95% CI: 1.08–1.16).21 Severe psoriasis was associated with a significantly increased risk of cardiovascular mortality (RR 1.39; 95% CI: 1.11–1.74), MI (RR 1.70; 95% CI: 1.32–2.18), and stroke (RR 1.56; 95% CI: 1.32–1.84).21 Taking these risk ratios and background population event rates into account, psoriasis is associated with an estimated excess of 11,500 (95% CI: 1,169–24,407) major adverse cardiovascular events each year.21

An observational study of 3,236 psoriasis patients and 2,500 controls found a higher prevalence of ischemic heart disease (odds ratio [OR] 1.78; 95% CI: 1.51–2.11), cerebrovascular (OR 1.70; 95% CI: 1.33–2.17) and peripheral vascular (OR 1.98; 95% CI: 1.32–2.82) diseases, and arteriosclerosis (OR 2.18; 95% CI: 1.59–3.01) after cardiovascular risk factors were controlled for.22 Psoriasis was also found to be an independent risk factor for mortality (OR 1.86; 95% CI: 1.56–2.21).22

In a Danish study of 36,765 mild psoriasis patients, 2,793 severe psoriasis patients, and 4,478,926 other individuals, atrial fibrillation and ischemic stroke incidence rates were increased in the psoriasis population.23 Atrial fibrillation rates were found to be 3.03 per 1,000 observational years for normal controls, 4.67 for mild psoriasis patients, and 5.96 for severe psoriasis patients (P<0.05).23 Ischemic stroke incidence rates were 3.06, 4.54, and 6.82 per 1,000 observational years for reference patients, mild psoriasis patients, and severe psoriasis patients, respectively (P<0.05).23

Increased IMT and carotid plaque are intermediate risk factors for subclinical atherosclerosis and a predictor of stroke and MI.24 One recent study found a significant association between psoriasis and increased common carotid artery IMT (beta 0.016; CI: 0.004–0.028; P<0.008) after controlling for cardiovascular risk factors.25 However, carotid plaque’s association with psoriasis was not significantly significant (OR 1.12; 95% CI: 0.85–1.47).25 Three other case-control studies detected a similar increase in IMT and no significant atherosclerotic plaque difference when psoriasis patients were compared to controls.2628

Increased arterial stiffness is also associated with psoriasis. One study found a significantly higher pulse wave velocity (a marker for arterial stiffness) in psoriasis patients versus normal controls (8.78±1.98 versus 7.78±2.0 m/second; P=0.03) after controlling for cardiovascular risk factors.29 Another study by Balta et al reported a pulse wave velocity of 7.63 versus 6.96 (P<0.01) for psoriasis versus control patients. Balta et al also found increased levels of CRP in psoriasis patients versus controls (2.54±2.6 versus 1.22±0.94; P<0.01).3 CRP levels were found to be independently predictive of increased arterial stiffness.3,30

In a study by Ludwig et al, there was an increased prevalence (59.4% versus 28.1%, P=0.015) of coronary artery calcification in 32 psoriasis patients compared to controls.31 Other studies have found that coronary artery calcification scores predict atherosclerotic cardiovascular disease events independently of standard risk factors and CRP levels.32,33 A study by Osto et al found that, in young patients with severe psoriasis and no heart disease, coronary flow rate was reduced, suggesting early coronary microvascular dysfunction.34 The risk of coronary microvascular dysfunction correlated with Psoriasis Area Severity Index (PASI) scores independently of other cardiovascular risk factors.34

Therapeutic implications

Because cardiovascular disease represents an important comorbidity in psoriasis, it is important to screen patients for cardiovascular risk factors and refer patients to the appropriate specialists if cardiovascular disease is suspected. Recent surveys indicate that most physicians are unaware of the connection between psoriasis and cardiovascular disease.35,36 Dermatologists should also ask psoriasis patients with cardiovascular disease about their treatment, as it could influence the course of their psoriasis therapy. Counseling patients on healthy lifestyle habits (diet, exercise, and smoking cessation) is also warranted to reduce cardiovascular risk factors.

Methotrexate is used in the treatment of psoriasis and has been found to decrease the risk of cardiovascular disease in certain chronic inflammatory diseases.37 However, long-term methotrexate use was also found to cause hyperhomocysteinemia, which is an independent risk factor for vascular disease.38 In a retrospective study of US veterans with psoriasis or rheumatoid arthritis, methotrexate was found to significantly reduce the risk of vascular disease (psoriasis: RR 0.73; 95% CI: 0.55–0.98).38 When folic acid was taken concurrently with methotrexate to lower homocysteine levels, the incidence of vascular disease in psoriasis patients decreased even further (psoriasis: RR 0.56; 95% CI: 0.39–0.80).38 In a meta-analysis of ten studies, methotrexate was associated with a 21% lower risk of total cardiovascular disease (n=10 studies; 95% CI: 0.73–0.87; P<0.001) and an 18% lower risk of MI (n=5; 95% CI: 0.71–0.96; P=0.01), without evidence for statistical between-study heterogeneity (P=0.30 and P=0.33, respectively).37

TNF inhibitors have been associated with a reduced incidence of MI to a greater degree than methotrexate.39 A retrospective cohort study of 8,845 psoriasis patients found that treatment with TNF inhibitors resulted in a 55% reduction in MI incidence when compared to the topical therapy group (P<0.001).40 A literature review of TNF inhibitors in the treatment of psoriasis concluded that TNF inhibitors have beneficial effects on cardiovascular biomarkers (CRP and erythrocyte sedimentation rate [ESR]) and may prevent MI.39 A combination of methotrexate and TNF inhibitors is thought to provide the largest cardioprotective effect.39 In a study by Piaserico et al, biologics were found to be more effective than traditional treatments (methotrexate, acitretin, cyclosporine, and psoralen ultraviolet A [PUVA]) in the elderly population.41

Obesity

Introduction and pathophysiology

Obesity is considered a chronic, low-grade inflammatory condition.42 Inflammatory-type macrophages in adipose tissue stimulate the secretion of inflammatory mediators, which establish and maintain an inflammatory state.43 Adipose tissue then secretes adipocytokines, such as TNF-alpha, IL-6, and leptin, which may also play a role in the pathogenesis of psoriasis.43 Leptin provides information about the body’s nutritional and fat mass to the hypothalamus and regulates appetite and body weight.44 Hyperleptinemia has been associated with increased common carotid artery IMT and arterial thrombosis.45 Studies have shown that psoriasis patients have increased levels of leptin, and psoriasis itself is an independent risk factor for hyperleptinemia.4650 High levels of leptin are hypothesized to mediate proliferative and antiapoptotic processes in T-cells as well as increase the production of other proinflammatory cytokines such as IL-6 and TNF-alpha, processes that are seen in psoriasis.50,51

Scientific evidence

Significant associations between psoriasis and obesity or being overweight have been observed. The relationship is hypothesized to be bidirectional, with obesity predisposing patients to psoriasis and psoriasis increasing the risk of obesity.52 A meta-analysis of 16 observational studies analyzed the epidemiological associations between psoriasis and obesity in a population of 2.1 million patients (201,831 psoriasis patients).53 The pooled OR for obesity among patients with mild psoriasis was 1.46 (95% CI: 1.17–1.82) and 2.23 (95% CI: 1.63–3.05) for severe psoriasis.53 One incidence study found that psoriasis patients have a HR of 1.18 (95% CI: 1.14–1.23) for new-onset obesity.53 Compared with the general population, psoriasis patients in this study had a higher prevalence and incidence of obesity.53 Patients with more severe psoriasis have higher odds of obesity compared to those with mild psoriasis.53

Therapeutic implications

Patients should be counseled on weight loss and leading healthy, active lifestyles. In a randomized clinical study, 60 mild-to-moderate psoriasis patients with body mass indices (BMIs) between 27 and 40 kg/m2 were allocated to either an intensive weight-loss therapy group or a standard routine dietary guidance group.54 After 16 weeks, there was a statistically different weight loss between the two groups of 15.4 kg (95% CI: 12.3–18.5 kg; P<0.001).54 Dieting patients experienced a greater mean reduction in their PASI score compared to controls (−2.3 versus 0.3), although this difference was not statistically significant (P=0.06).54

Several studies have found that TNF inhibitors such as adalimumab, etanercept, and infliximab can cause weight gain.5559 The mechanism of weight gain among patients treated with TNF inhibitors is still unclear, although TNF-alpha is known to be involved in body weight homeostasis and is purported to influence appetite by modulating leptin release from adipocytes.60 Furthermore, psoriasis patient weights can affect the dosing of certain therapeutics. For example, weight-dosed biologics (such as infliximab) demonstrate consistent clinical responses in overweight and obese patient populations, while fixed-dosed biologics (such as etanercept) may not.61

Diabetes mellitus

Introduction and pathophysiology

Type 2 diabetes mellitus (DM) is a metabolic disorder characterized by increased insulin resistance and hyperglycemia. Th1 cytokines that are overproduced in psoriasis are thought to promote insulin resistance as well.6264 Obesity is a major risk factor for type 2 DM, and the chronic secretion of inflammatory adipocytokines is also thought to contribute to psoriasis as well.65

Scientific evidence

Azfar et al conducted a large cohort study of 108,132 psoriasis patients.65 After controlling for age, sex, BMI, hypertension, and hyperlipidemia, psoriasis was found to be an independent risk factor for incident type 2 DM (HR 1.14; 95% CI: 1.10–1.18).65 The risk was greatest in patients with severe disease (HR 1.46; 95% CI: 1.30–1.65).65 A population-based nested analysis of 1,061 patients found an OR of 1.31 (95% CI: 1.13–1.51) for incident psoriasis among people with DM after controlling for hyperlipidemia, smoking, hypertension, infections, and oral steroid use.63 The prevalence of type 2 DM in mild and severe psoriasis and in controls in a case-control study of 1,835 psoriasis patients was 37.4%, 41%, and 16%, respectively (P=0.00001).66

Therapeutic implications

There have been multiple case reports of hypoglycemia associated with etanercept, an anti-TNF treatment, in patients with psoriasis and type 2 DM.6769 TNF-mediated inflammation has been shown to mediate insulin resistance.70 Because of their higher TNF levels, diabetic patients may need higher insulin doses.67 When anti-TNF therapy is started, insulin sensitivity is thought to improve and insulin requirements are lowered.67 Dermatologists should be aware that diabetic patients on both anti-TNF and insulin therapy may experience hypoglycemia.6769

Thiazolidinediones (eg, pioglitazone and rosiglitazone) are antidiabetic drugs that improve insulin sensitivity and have anti-inflammatory effects.71,72 They activate peroxisome proliferator-activated receptor-gamma, which leads to inhibition of proliferation of psoriatic keratinocytes.73 A meta-analysis of the efficacy of thiazolidinediones on psoriasis found a significant decrease in mean PASI scores of people on pioglitazone, whereas the improvement on rosiglitazone was not significant.74

Hypertension

Introduction and pathophysiology

Although psoriasis and hypertension share common risk factors, such as smoking and obesity, psoriasis has been found to be independently associated with hypertension. The exact mechanism underlying the relationship between psoriasis and hypertension is unknown, but there are a number of hypotheses about this association.

Alterations to the renin–angiotensin system in psoriasis may contribute to poor blood pressure control. Psoriasis patients have elevated plasma renin activity and elevated angiotensin-converting enzyme (ACE) activity.7577 High ACE levels may play a role in altering cytokine regulation in vasculature.78 Certain ACE gene polymorphisms have also been associated with increased susceptibility to psoriasis, but these results are controversial.78

Endothelin-1, which is a potent vasoconstrictor, was also found to be elevated in the serum and lesional skin of psoriasis patients.79 Increased oxidative stress in psoriasis patients is also hypothesized to impair the vasodilatory mechanism of the endothelium.80,81

Some investigators hypothesized that psoriasis patients were less physically active due to potential embarrassment, but psoriasis was found to be independently associated with hypertension even after controlling for physical activity level.62

Scientific evidence

In a recent meta-analysis of 24 observational studies, the pooled ORs for hypertension among patients with mild and severe psoriasis were 1.30 (95% CI: 1.15–1.47) and 1.49 (95% CI: 1.20–1.86), respectively.53 In a case-control study of 12,502 psoriasis patients, the prevalence of hypertension was significantly higher in psoriasis patients than in controls (38.8% and 29.1%, respectively; P<0.001).82 In a multivariate analysis, hypertension was associated with psoriasis after controlling for other risk factors (OR 1.37; 95% CI: 1.29–1.46).82 Other studies have reported hypertension prevalence of 40.3%, 32%, and 11.55% in severe psoriasis, mild-to-moderate psoriasis, and controls, respectively (P=0.00001).66 A cross-sectional study from the UK reported an OR of 1.03 (95% CI: 1.01–1.06) for hypertension in patients with mild psoriasis.83

Therapeutic implications

Dermatologists should encourage patients to monitor their blood pressure and stress the importance of healthy lifestyle habits. Patients who are hypertensive should follow up with their primary care provider and adhere to treatment.

Hypertension is a commonly reported side effect of the anti-psoriasis drug cyclosporine. Cyclosporine has been found to significantly increase blood pressure in a dose-dependent fashion.84 A meta-analysis of 17 trials found that lower doses (1–4 mg/kg/day) increased mean blood pressure by an average of 5 mmHg, and higher doses (>10 mg/kg/day) increased mean blood pressure by an average of 11 mmHg.84 Therefore, care must be taken to monitor patient blood pressure when using cyclosporine in psoriasis patients.84

Beta blockers have been reported to exacerbate psoriasis.85 Beta blockers reduce intracellular concentrations of calcium, which may lead to an accelerated proliferation of keratinocytes and polymorphonuclear leukocytes.86 However, a case-control study in the UK did not find a significant association between antihypertensive medications and psoriasis.63

Dyslipidemia

Introduction and pathophysiology

Dyslipidemia is a broad term encompassing abnormalities of plasma lipid levels or composition. Dyslipidemia is a well-established cardiovascular risk factor for CAD, stroke, MI, and cardiovascular mortality.8790 Typically, it presents as increased low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and triglyceride levels and decreased high-density lipoprotein (HDL) levels.

Several purported mechanisms underlying the association between dyslipidemia and psoriasis are the activation of Th1 cells, autoantibodies recognizing oxidized LDL, and psoriasis medications such as oral retinoids and cyclosporine.91 Specifically, the cytokines IL-1, IL-6, and TNF-alpha that mediate psoriasis may alter the function of hepatocytes and arterial smooth muscle cells, resulting in altered lipoprotein compositions, enhanced expression of cellular adhesion molecules, and increased lipid deposition on arterial walls. These processes ultimately lead to the development of arterial plaques.91 Cytokines increase the expression of matrix metalloproteinases, which degrade the plaque’s fibrous cap. Eventually, the plaque may rupture and life-threatening thrombi may form.91,92

IL-1, IL-6, and TNF-alpha are also involved in the inhibition of lipoprotein lipase activity, which results in decreased triglyceride clearance and increased plasma triglyceride levels.9395 Some studies suggest that these cytokines may elevate lipid levels by augmenting lipolysis and stimulating hepatic de novo fatty acid synthesis.96,97

Psoriasis is associated with an increased production of reactive oxygen species that overwhelm the body’s antioxidant capacity.98 Levels of lipid peroxidation products can indirectly measure the production of reactive oxygen species. Lipid peroxidation markers such as malondialdehyde, oxidized LDL (ox-LDL), thiobarbituric acid, and anti-ox-LDL autoantibody were found to be elevated in patients with severe psoriasis compared to those with mild psoriasis.99 Ox-LDL, which is found in the upper epidermis of psoriatic skin, is also an initiator of inflammation and influences the adhesion and oxidant status of endothelial cells.100 This mechanism is thought to implicate ox-LDL in early atherogenesis.

Scientific evidence

A systematic review of 25 cross-sectional and case-control studies found that psoriasis was associated with greater odds of dyslipidemia.101 Twenty of the 25 studies reported a positive association between psoriasis and dyslipidemia, with ORs ranging from 1.04–5.55.101 The three studies that accounted for psoriasis severity found that greater psoriasis severity was associated with a higher prevalence of dyslipidemia, with the ORs for mild and severe psoriasis ranging from 1.10–3.38 and 1.36–5.55, respectively.101 Multiple measures of dyslipidemia were affected, with studies showing increased triglycerides, LDL, total cholesterol, and lipoprotein levels, as well as lowered HDL.101

Therapeutic implications

Treatment with the anti-TNF drugs etanercept, infliximab, and adalimumab has been shown to reduce the levels of inflammatory markers (CRP) and lipid peroxidation products while increasing serum antioxidant capacity.102 These effects are associated with an increase in the level of paraoxonase 1 (PON1), an antioxidant enzyme and anti-inflammatory enzyme associated with HDL. HDL levels also increased after treatment.102

Anti-TNF drugs have also been found to induce structural changes in the HDL protein composition.103 During inflammation, the HDL protein composition changes so that it is unable to protect LDL from oxidation. Anti-TNF drugs were found to restore HDL’s protein composition back to an atheroprotective state in patients with rheumatoid arthritis.103 However, other studies have found no favorable change in lipid profiles of psoriasis patients with TNF inhibitors.104108

Drugs that have an unfavorable effect on lipid profile include retinoids and cyclosporine. Retinoids increase triglyceride levels and total, LDL, and VLDL cholesterol and decrease HDL levels.109114 Cyclosporine has also been linked to hypertriglyceridemia, although the mechanism of this association is unclear. Eighty percent of plasma cyclosporine is bound to VLDL, and cyclosporine is hypothesized to either increase hepatic output of VLDL or interfere with the clearance of VLDL.115

Statins, which lower LDL and maintain plaque stability, also modulate the inflammatory response and are thus of interest in psoriasis. Statins lower CRP and TNF-alpha levels while downregulating adhesion molecules on leukocytes and endothelial cells and inhibiting major histocompatibility complex II expression and chemokine receptors on Th1 cells.116 Statins can differ by ninefold in their ability to block nuclear factor kappa B, a transcription factor needed for proinflammatory cytokine production.117 This may explain why there have been conflicting reports on whether statins help or hurt in psoriasis.118,119 One small pilot study evaluated the efficacy of simvastatin in treating plaque psoriasis and found a significant reduction in PASI scores of 47.34%.120 Fibrates, another class of lipid-lowering drugs, may exacerbate psoriasis.121,122

Metabolic syndrome

Introduction and pathophysiology

Metabolic syndrome is a cluster of risk factors for cardiovascular disease, such as hypertension, central obesity, glucose intolerance, and dyslipidemia. A diagnosis of metabolic syndrome is made when a person has at least three of the following five conditions, as defined by the National Cholesterol Education Program’s Adult Treatment Panel III (NCEP ATP III): 1) fasting glucose 100 mg/dL or greater (or receiving drug therapy for hyperglycemia); 2) blood pressure 130/85 mmHg or higher (or receiving drug therapy for hypertension); 3) triglycerides 150 mg/dL or higher (or receiving drug therapy for hypertriglyceridemia); 4) HDL cholesterol (high density lipoprotein cholesterol) less than 40 mg/dL in men or less than 50 mg/dL in women (or receiving drug therapy for reduced HDL-C); and 5) waist circumference 102 cm (40 inches) or greater in men or 88 cm (35 inches) or greater in women; if Asian American, 90 cm (35 inches) or greater in men or 80 cm (32 inches) or greater in women.123

Metabolic syndrome confers double the risk for CAD and increases the risks of stroke, fatty liver disease, and cancer.123 The prevalence of metabolic syndrome in the general population has been estimated to be between 15% and 24%.124,125 Psoriasis patients have an increased prevalence of metabolic syndrome.123

Scientific evidence

A meta-analysis of 12 observational studies found a pooled OR of 2.26 for metabolic syndrome among a population of 41,853 psoriasis patients. The prevalence of metabolic syndrome ranged from 14% to 40%.123 A population-based, cross-sectional study done in the UK found that the prevalence of metabolic syndrome correlated with psoriasis disease severity. The ORs for mild and severe psoriasis were 1.22 (95% CI: 1.11–1.35) and 1.98 (95% CI: 1.62–2.43), respectively.126 A cross-sectional study of a random sample of the US population found that 40% of psoriasis patients in the US had metabolic syndrome, which was almost double the control prevalence of 23%.123

Therapeutic implications

Patients with suspected metabolic syndrome should be referred to a specialist for management. Obesity, dyslipidemia, diabetes, and hypertension should also be screened for.

NAFLD

Introduction and pathophysiology

NAFLD is defined as an excessive accumulation of triglycerides in hepatocytes of patients without a history of excessive alcohol consumption.127 NAFLD is classified according to severity: simple NAFLD only consists of fatty infiltration; NASH (nonalcoholic steatohepatitis) is characterized by fatty infiltration and lobular inflammation; NAFLD with fibrosis or cirrhosis is the most severe stage and can progress to hepatocellular carcinoma.127 NAFLD is considered the hepatic expression of metabolic syndrome and is also associated with type 2 DM and dyslipidemia.128,129

The pathophysiology behind the association of NAFLD with psoriasis is thought to be related to chronic inflammation – proinflammatory adipokines and skin-derived cytokines may increase insulin resistance, which promotes hepatic lipid accumulation.130

Scientific evidence

A cross-sectional study of 142 Italian patients found a significant association between psoriasis and NAFLD.131 Fifty-nine percent of patients received a clinical diagnosis of NAFLD, 21% had factors associated with NAFLD (viral hepatitis, significant ethanol and methotrexate use), and 19% had normal livers.131 NAFLD in psoriasis patients was significantly correlated with metabolic syndrome, hypercholesterolemia, hypertriglyceridemia, and psoriatic arthritis.131

A case-control study found a 47% prevalence of NAFLD in 130 psoriasis patients. This association was present after controlling for BMI, suggesting that NAFLD is linked to psoriasis independently of obesity.132

Therapeutic implications

NAFLD should be suspected in psoriasis patients with an associated comorbidity such as metabolic syndrome, obesity, diabetes, dyslipidemia, or hypertension. Liver enzyme tests should be ordered if risk factors for NAFLD are present and the patient should be referred to the appropriate specialist.

Methotrexate is known to be hepatotoxic and has been linked to the development of fatty liver disease, fibrosis, and cirrhosis.133 Patients on methotrexate may develop elevations of serum aspartate aminotransferase and alanine aminotransferase; however, these are usually mild and self-limiting, and disappear with dose modification of methotrexate.134,135 Methotrexate depletes hepatic folate stores. Although a relationship between hepatic toxicity and folate depletion has not been established, oral folic acid supplements were found to reduce serum transaminase levels in patients on low-dose, long-term methotrexate therapy.136,137

In the past, the American Academy of Dermatology and National Psoriasis Foundation recommended that all patients with psoriasis undergo liver biopsies after every 1–1.5 g of cumulative methotrexate.138 In 2009, these recommendations were updated. The American Academy of Dermatology now recommends liver biopsies only for patients with risk factors for hepatotoxicity.139,140 These include a history of more than moderate alcohol consumption, persistently abnormal liver chemistry studies, a history of liver disease, DM, obesity, history of exposure to hepatotoxic drugs, absence of folate supplementation, and hyperlipidemia.140 Psoriasis patients without risk factors can be considered for liver biopsy after 3.5–4 g of cumulative methotrexate.131

Cancer

Introduction and pathophysiology

A number of studies have investigated the link between psoriasis and cancer; the data have been inconsistent, however.141148 The chronic, inflammatory state induced by psoriasis is thought to initiate certain neoplastic diseases.149 As psoriasis is an immune-mediated disease, its pathophysiology is associated with an increased risk of lymphoma.142,150 This association is seen in other Th1-mediated diseases as well, such as rheumatoid arthritis.151,152

Patients with more severe psoriasis may also be receiving drugs such as cyclosporine, methotrexate, or PUVA therapy, which have all been associated with malignancies.153 A higher prevalence of alcohol or cigarette abuse, risk factors for cancer, is also seen in psoriasis patients.154,155

Scientific evidence

A large population-based study found an association between duration and severity of psoriasis and specific cancers.153 Patients with a long duration of psoriasis were at an increased risk of colorectal, bladder, kidney, pancreatic, and lymphohematopoietic cancers.153 Patients with more severe psoriasis who were receiving oral therapy were also at an increased risk of developing cancer (OR 10.17; 95% CI: 3.24–31.94).153 An analysis of patients without oral treatment yielded adjusted ORs of 1.59 (95% CI: 1.01–2.50) for patients with psoriasis of under 2 years duration and 2.12 (95% CI: 1.45–3.10) for those with psoriasis of greater than 2 years duration for lymphohematopoietic cancers.153

A cohort study of 7,061 Taiwanese psoriasis patients found that psoriasis patients were more likely to develop non-melanoma skin cancer and lymphoma.156 Patients who had never received systemic therapy were also more likely to develop non-melanoma skin cancer and lymphoma, suggesting that psoriasis could be an independent risk factor for these malignancies.156

Therapeutic implications

Systemic treatments such as PUVA, methotrexate, and cyclosporine have been linked to increased risk of cancer. The PUVA Follow-Up Study, which tracked 1,380 psoriasis patients for 30 years, found a dose-dependent increase in the risk of squamous cell carcinoma (SCC) and a moderate increase in the risk of basal cell carcinoma after PUVA therapy.157 More than one-half of patients who received 350 or more PUVA treatments developed SCC, and a significant risk was noted after 150 treatments.157 The risk of malignant melanoma also increased about 15 years after initiation of PUVA treatment, especially among patients who underwent more than 250 treatments.147 Physicians should weigh the benefits and risks for each patient, taking into account their baseline risk for skin cancer and the number of PUVA treatments needed.157

The PUVA Follow-Up Study also found an increased incidence of lymphoma in patients who were taking high doses of methotrexate in addition to receiving PUVA therapy (incidence rate ratio 4.39; 95% CI: 1.59–12.06).146 Patients who were on PUVA therapy only had rates of lymphoma comparable to those of the general population (incidence rate ratio 0.85; 95% CI: 0.37–1.67).146

A cohort study of 1,252 severe psoriasis patients found that low-dose cyclosporine (2.7–3.1 mg/kg/day) was associated with a sixfold increase in the risk of SCC within a 5-year follow-up. Patients at greatest risk were those who were treated with cyclosporine for more than 2 years or previously exposed to PUVA, immunosuppressants, or methotrexate.158 Cyclosporine should not be used together with phototherapy, before or after PUVA, or in patients with a history of SCC or melanoma.159

Some meta-analyses and observational studies have found that TNF-alpha inhibitors are associated with an increased risk of malignancy in rheumatoid arthritis patients, although the evidence is conflicting.160162 Because rheumatoid arthritis patients are usually on concomitant systemic immunosuppressants while psoriasis patients are typically treated with monotherapy, it is unclear if safety data from rheumatoid arthritis studies can be generalized to psoriasis.160,162 One meta-analysis of data from 20 randomized clinical trials of adult patients with plaque psoriasis and psoriatic arthritis treated with anti-TNF-alpha agents did not find a statistically significant increase in the risk of malignancies.163

Anxiety and depression

Introduction, pathophysiology, and scientific evidence

Psoriasis can have profound psychosocial effects and negatively impact many aspects of quality of life.164 Patients with psoriasis often report suffering from high levels of stress, social stigmatization, and physical limitations from their disease.164

The visibility of psoriatic lesions can often result in feelings of embarrassment, social withdrawal, and lack of self-esteem.164 Using the Psoriasis Life Stress Inventory, Gupta and Gupta surveyed 217 patients with a range of psoriasis severity. The most commonly reported stressor was due to disfigurement. Over one-half of patients reported feeling self-conscious around strangers.165 In a study by Gupta et al, 26% of patients noted that they had experienced an episode in which people “made a conscious effort not to touch them” in the previous month.166 Another study found that 83% of patients with moderate-to severe psoriasis felt they “often” or “always” needed to hide their psoriasis.164 Seventy-four percent reported that their self-confidence was “often” or “always” affected by their psoriasis, and 83% would “often” or “always” avoid social activities such as swimming.164

In a self-perpetuating cycle, psoriasis causes stress and stress exacerbates psoriasis. Psychological stress is shown to play a role in the onset and exacerbation of psoriasis.167 In one study, 88% of patients attributed psychological stress to exacerbation of their psoriasis and 68% of patients reported experiencing a psychologically stressful life event in the 3 months before the onset of psoriasis.167

A further analysis of the Psoriasis Life Stress Inventory revealed that psoriasis patients experienced stress from anticipating the reaction and avoidance of others and stress from fear of being evaluated exclusively on the basis of their skin.168 Psoriasis patients also had significantly higher levels of experiences of stigmatization compared to other dermatology patients.168

Depression and anxiety are important psychological comorbidities of psoriasis. Increased levels of proinflammatory cytokines such as IL-1, TNF-alpha, and IFN-gamma that are seen in psoriasis are purported to act as neuromodulators and may mediate depressive disorders.169 Administration of proinflammatory cytokines in cancer and hepatitis C therapies, and other chronic inflammatory diseases such as rheumatoid arthritis, have been associated with depression.169 Researchers have generally found higher levels of depression in patients with a greater percentage of their skin affected by psoriasis.170 Higher rates of suicidal ideation that correlate with higher self-ratings of disease severity have also been reported.171

Therapeutic implications

Physicians should screen for anxiety and depression and explore patients’ perceptions of their disease. Various psychosocial interventions have been demonstrated to help patients.172 In a large study, pharmacotherapy plus a 6-week program of cognitive behavioral therapy led to significantly greater decreases in psoriasis severity, self-reported disability, and psychological distress, than pharmacotherapy only.172 These improvements were maintained for more than 6 months after the completion of cognitive behavioral therapy.172 Effective treatment for psoriasis should involve a multidimensional approach that integrates psychosocial well-being and patients’ perceptions of their disease.

Inflammatory bowel disease

Introduction and pathophysiology

Systemic inflammation plays an important role in psoriasis, Crohn’s disease, and ulcerative colitis. Th17 cells in psoriatic skin produce IL-23, which is an essential cytokine for intestinal inflammation.173 Polymorphisms in IL-23 and IL-12B receptor genes are also thought to play a role in all three disease processes.174177

The susceptibility loci of psoriasis, Crohn’s disease, and ulcerative colitis all lie in the 6p21 locus, which encompasses the major histocompatibility complex. The IBD3 locus associated with Crohn’s disease and ulcerative colitis and the PSORS1 locus of psoriasis lie here as well.174,178,179

Scientific evidence

A case-control study of 12,502 psoriasis patients in the Clalit Health Services database found a significantly higher prevalence of both Crohn’s disease (0.5% and 0.2%, respectively; P<0.001) and ulcerative colitis (0.5% and 0.3%, respectively; P=0.002) compared with the control group.180 Crohn’s disease and ulcerative colitis were both associated with psoriasis (ORs 2.49 and 1.64, respectively).180

In a Nurses’ Health Study (NHS) of 174,476 women with psoriasis or psoriatic arthritis, psoriasis was associated with an increased risk of developing Crohn’s disease during both NHS I (1996–2008) (RR 4.00; 95% CI: 1.72–9.27) and NHS II (1991–2007) (RR 3.76; 95% CI: 1.82–7.74).181 The risk of Crohn’s disease was highest among women with concomitant psoriatic arthritis (RR 6.43; 95% CI: 2.04–20.32).181

A retrospective cohort study using US health care claims data investigated concurrent autoimmune diseases in patients with psoriasis and psoriatic arthritis.182 The psoriatic arthritis group had higher prevalence ratios of Crohn’s disease, ulcerative colitis, and inflammatory bowel disease compared to the psoriasis-only group.182

Other digestive diseases, such as celiac disease, also show a higher prevalence in the psoriasis population. In a case-control study by Birkenfeld et al, the prevalence of celiac disease in patients from Israel with psoriasis was 0.29%, compared to 0.11% in controls (P<0.001). Psoriasis was associated with celiac disease with an OR of 2.73 (95% CI: 1.65–4.53).183 Wu et al also found an association between psoriasis and celiac disease, with an OR of 2.2 (95% CI: 1.5–3.2) in a population of 25,341 Southern California Kaiser Permanente psoriasis patients.184

Therapeutic implications

Systemic drugs used to treat moderate-to-severe psoriasis are also indicated in some inflammatory bowel diseases. Methotrexate is used for treating active Crohn’s disease in steroid-dependent patients. TNF-alpha inhibitors such as infliximab and adalimumab have been employed for severe active Crohn’s disease that has not responded to conventional treatment.185

Paradoxically, TNF-alpha inhibitors have been shown to induce psoriasis in certain studies.178,185187 All three TNF-alpha inhibitors that are US Food and Drug Administration-approved for psoriasis (infliximab, etanercept, and adalimumab) were associated with the induction of psoriasiform lesions, with a mean time of 9.5 months for the appearance of the lesions.178,185187 It is thought that TNF-alpha inhibitors could favor the recruitment of activated T-cells in the skin of patients genetically predisposed to an enhancement of the chemokine receptor CXCR3.188

Certain psoriasis treatments can cause gastrointestinal side effects, and it could be difficult to separate a diagnosis of inflammatory bowel disease from these side effects. Infliximab, adalimumab, ustekinumab, methotrexate, acitretin, and cyclosporine have side effects of abdominal pain, diarrhea, dyspepsia, and nausea.

Conclusion

Because of the wide range of comorbid conditions associated with psoriasis, the need for comprehensive screening and treatment must be recognized and addressed. The concept of psoriasis as a systemic inflammatory disorder provides the pathophysiologic link with many associated diseases. Therapeutic interventions for psoriasis may exacerbate comorbid conditions, and vice versa. Therefore, appropriate management of psoriasis must involve an integrated approach.

Disclosure

The authors report no conflicts of interest in this work.


References

1.

Onumah N, Kircik LH. Psoriasis and its comorbidities. J Drugs Dermatol. 2012;11(5):5–10

2.

Mehta NN, Yu Y, Pinnelas R, et al. Attributable risk estimate of severe psoriasis on major cardiovascular events. Am J Med. 2011;124(8):775.e1–e6.

3.

Balta I, Balta S, Demirkol S, et al. Aortic arterial stiffness is a moderate predictor of cardiovascular disease in patients with psoriasis vulgaris. Angiology. 2014;65(1):74–78.

4.

Späh F. Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach. Br J Dermatol. 2008;159 Suppl 2:10–17.

5.

Yildiz M. Arterial distensibility in chronic inflammatory rheumatic disorders. Open Cardiovasc Med J. 2010;4:83–88.

6.

Costa L, Caso F, D’Elia L, et al. Psoriatic arthritis is associated with increased arterial stiffness in the absence of known cardiovascular risk factors: a case control study. Clin Rheumatol. 2012;31(4):711–715.

7.

Chodorowska G, Wojnowska D, Juszkiewicz-Borowiec M. C-reactive protein and alpha2-macroglobulin plasma activity in medium-severe and severe psoriasis. J Eur Acad Dermatol Venereol. 2004;18(2):180–183.

8.

Koenig W, Sund M, Fröhlich M, et al. C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation. 1999;99(2):237–242.

9.

Vanizor Kural B, Orem A, Cims¸it G, Uydu HA, Yandi YE, Alver A. Plasma homocysteine and its relationships with atherothrombotic markers in psoriatic patients. Clin Chim Acta. 2003;332(1–2):23–30.

10.

Vanizor Kural B, Orem A, Cims¸it G, Yandi YE, Calapoglu M. Evaluation of the atherogenic tendency of lipids and lipoprotein content and their relationships with oxidant-antioxidant system in patients with psoriasis. Clin Chim Acta. 2003;328(1–2):71–82.

11.

Rocha-Pereira P, Santos-Silva A, Rebelo I, Figueiredo A, Quintanilha A, Teixeira F. The inflammatory response in mild and in severe psoriasis. Br J Dermatol. 2004;150(5):917–928.

12.

Bhushan M, McLaughlin B, Weiss JB, Griffiths CE. Levels of endothelial cell stimulating angiogenesis factor and vascular endothelial growth factor are elevated in psoriasis. Br J Dermatol. 1999;141(6):1054–1060.

13.

Nofal A, Al-Makhzangy I, Attwa E, Nassar A, Abdalmoati A. Vascular endothelial growth factor in psoriasis: an indicator of disease severity and control. J Eur Acad Dermatol Venereol. 2009;23(7):803–806.

14.

Bhardwaj S, Roy H, Heikura T, Ylä-Herttuala S. VEGF-A, VEGF-D and VEGF-D(DeltaNDeltaC) induced intimal hyperplasia in carotid arteries. Eur J Clin Invest. 2005;35(11):669–676.

15.

McDonald I, Connolly M, Tobin AM. A review of psoriasis, a known risk factor for cardiovascular disease and its impact on folate and homocysteine metabolism. J Nutr Metab. 2012;2012:965385.

16.

Brazzelli V, Grasso V, Fornara L, et al. Homocysteine, vitamin B12 and folic acid levels in psoriatic patients and correlation with disease severity. Int J Immunopathol Pharmacol. 2010;23(3):911–916.

17.

Duell PB, Malinow MR. Homocyst(e)ine: an important risk factor for atherosclerotic vascular disease. Curr Opin Lipidol. 1997;8(1):28–34.

18.

El-Khairy L, Ueland PM, Refsum H, Graham IM, Vollset SE; European Concerted Action Project. Plasma total cysteine as a risk factor for vascular disease: The European Concerted Action Project. Circulation. 2001;103(21):2544–2549.

19.

Malerba M, Gisondi P, Radaeli A, Sala R, Calzavara Pinton PG, Girolomoni G. Plasma homocysteine and folate levels in patients with chronic plaque psoriasis. Br J Dermatol. 2006;155(6):1165–1169.

20.

Richetta AG, Mattozzi C, Macaluso L, et al. Homocysteine plasmatic status in patients with psoriasis. Eur J Dermatol. 2011;21(4):621–623.

21.

Armstrong EJ, Harskamp CT, Armstrong AW. Psoriasis and major adverse cardiovascular events: a systematic review and meta-analysis of observational studies. J Am Heart Assoc. 2013;2(2):e000062.

22.

Prodanovich S, Kirsner RS, Kravetz JD, Ma F, Martinez L, Federman DG. Association of psoriasis with coronary artery, cerebrovascular, and peripheral vascular diseases and mortality. Arch Dermatol. 2009;145(6):700–703.

23.

Ahlehoff O, Gislason GH, Jørgensen CH, et al. Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish Nationwide Cohort Study. Eur Heart J. 2012;33(16):2054–2064.

24.

Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation. 2007;115(4):459–467.

25.

Troitzsch P, Paulista Markus MR, Dörr M, et al. Psoriasis is associated with increased intima-media thickness – the Study of Health in Pomerania (SHIP). Atherosclerosis. 2012;225(2):486–490.

26.

Balci DD, Balci A, Karazincir S, et al. Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis. J Eur Acad Dermatol Venereol. 2009;23(1):1–6.

27.

Enany B, El Zohiery AK, Elhilaly R, Badr T. Carotid intima-media thickness and serum leptin in psoriasis. Herz. 2012;37(5):527–533.

28.

El-Mongy S, Fathy H, Abdelaziz A, et al. Subclinical atherosclerosis in patients with chronic psoriasis: a potential association. J Eur Acad Dermatol Venereol. 2010;24(6):661–666.

29.

Gisondi P, Fantin F, Del Giglio M, et al. Chronic plaque psoriasis is associated with increased arterial stiffness. Dermatology. 2009;218(2):110–113.

30.

Yiu KH, Yeung CK, Zhao CT, et al. Prevalence and extent of subclinical atherosclerosis in patients with psoriasis. J Intern Med. 2013;273(3):273–282.

31.

Ludwig RJ, Herzog C, Rostock A, et al. Psoriasis: a possible risk factor for development of coronary artery calcification. Br J Dermatol. 2007;156(2):271–276.

32.

Arad Y, Goodman KJ, Roth M, Newstein D, Guerci AD. Coronary calcification, coronary disease risk factors, C-reactive protein, and atherosclerotic cardiovascular disease events: the St Francis Heart Study. J Am Coll Cardiol. 2005;46(1):158–165.

33.

Arad Y, Spadaro LA, Roth M, Newstein D, Guerci AD. Treatment of asymptomatic adults with elevated coronary calcium scores with atorvastatin, vitamin C, and vitamin E: the St Francis Heart Study randomized clinical trial. J Am Coll Cardiol. 2005;46(1):166–172.

34.

Osto E, Piaserico S, Maddalozzo A, et al. Impaired coronary flow reserve in young patients affected by severe psoriasis. Atherosclerosis. 2012;221(1):113–117.

35.

Kimball AB, Wu Y. Cardiovascular disease and classic cardiovascular risk factors in patients with psoriasis. Int J Dermatol. 2009;48(11):1147–1156.

36.

Parsi KK, Brezinski EA, Lin TC, Li CS, Armstrong AW. Are patients with psoriasis being screened for cardiovascular risk factors? A study of screening practices and awareness among primary care physicians and cardiologists. J Am Acad Dermatol. 2012;67(3):357–362.

37.

Micha R, Imamura F, Wyler von Ballmoos M, et al. Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease. Am J Cardiol. 2011;108(9):1362–1370.

38.

Prodanovich S, Ma F, Taylor JR, Pezon C, Fasihi T, Kirsner RS. Methotrexate reduces incidence of vascular diseases in veterans with psoriasis or rheumatoid arthritis. J Am Acad Dermatol. 2005;52(2):262–267.

39.

Famenini S, Sako EY, Wu JJ. Effect of treating psoriasis on cardiovascular co-morbidities: focus on TNF inhibitors. Am J Clin Dermatol. 2014;15(1):45–50.

40.

Wu JJ, Poon KY. Association of gender, tumor necrosis factor inhibitor therapy, and myocardial infarction risk in patients with psoriasis. J Am Acad Dermatol. 2013;69(4):650–651.

41.

Piaserico S, Conti A, Console FL, et al. Efficacy and safety of systemic treatments for psoriasis in elderly patients. Acta Derm Venereol. Epub October 24, 2013.

42.

Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm. 2010;2010: pii 289645.

43.

Hamminga EA, van der Lely AJ, Neumann HA, Thio HB. Chronic inflammation in psoriasis and obesity: implications for therapy. Med Hypotheses. 2006;67(4):768–773.

44.

Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404(6778):661–671.

45.

Ciccone M, Vettor R, Pannacciulli N, et al. Plasma leptin is independently associated with the intima-media thickness of the common carotid artery. Int J Obes Relat Metab Disord. 2001;25(6):805–810.

46.

Wang Y, Chen J, Zhao Y, Geng L, Song F, Chen H-D. Psoriasis is associated with increased levels of serum leptin. Br J Dermatol. 2008;158(5):1134–1135.

47.

Chen YJ, Wu CY, Shen JL, et al. Psoriasis independently associated with hyperleptinemia contributing to metabolic syndrome. Arch Dermatol. 2008;144(12):1571–1575.

48.

Takahashi H, Tsuji H, Takahashi I, Hashimoto Y, Ishida-Yamamoto A, Iizuka H. Plasma adiponectin and leptin levels in Japanese patients with psoriasis. Br J Dermatol. 2008;159(5):1207–1208.

49.

Coimbra S, Oliveira H, Reis F, et al. Circulating adipokine levels in Portuguese patients with psoriasis vulgaris according to body mass index, severity and therapy. J Eur Acad Dermatol Venereol. 2010;24(12):1386–1394.

50.

Zhu KJ, Zhang C, Li M, Zhu CY, Shi G, Fan YM. Leptin levels in patients with psoriasis: a meta-analysis. Clin Exp Dermatol. 2013;38(5):478–483.

51.

Matarese G, Moschos S, Mantzoros CS. Leptin in immunology. J Immunol. 2005;174(6):3137–3142.

52.

Carrascosa JM, Rocamora V, Fernandez-Torres RM, et al. Obesity and psoriasis: inflammatory nature of obesity, relationship between psoriasis and obesity, and therapeutic implications. Actas Dermosifiliogr. 2014;105(1):31-44.

53.

Armstrong AW, Harskamp CT, Armstrong EJ. The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies. Nutr Diabetes. 2012;2:e54.

54.

Jensen P, Zachariae C, Christensen R, et al. Effect of weight loss on the severity of psoriasis: a randomized clinical study. JAMA Dermatol. 2013;149(7):795–801.

55.

Florin V, Cottencin AC, Delaporte E, Staumont-Sallé D. Body weight increment in patients treated with infliximab for plaque psoriasis. J Eur Acad Dermatol Venereol. 2013;27(2):e186–e190.

56.

Renzo LD, Saraceno R, Schipani C, et al. Prospective assessment of body weight and body composition changes in patients with psoriasis receiving anti-TNF-α treatment. Dermatol Ther. 2011;24(4):446–451.

57.

Prignano F, Ricceri F, Pescitelli L, et al. Comparison of body weight and clinical-parameter changes following the treatment of plaque psoriasis with biological therapies. Curr Med Res Opin. 2009;25(9):2311–2316.

58.

Saraceno R, Schipani C, Mazzotta A, et al. Effect of anti-tumor necrosis factor-alpha therapies on body mass index in patients with psoriasis. Pharmacol Res. 2008;57(4):290–295.

59.

Gisondi P, Cotena C, Tessari G, Girolomoni G. Anti-tumour necrosis factor-alpha therapy increases body weight in patients with chronic plaque psoriasis: a retrospective cohort study. J Eur Acad Dermatol Venereol. 2008;22(3):341–344.

60.

Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. J Clin Invest. 1997;100(11):2777–2782.

61.

Clark L, Lebwohl M. The effect of weight on the efficacy of biologic therapy in patients with psoriasis. J Am Acad Dermatol. 2008;58(3):443–446.

62.

Qureshi AA, Choi HK, Setty AR, Curhan GC. Psoriasis and the risk of diabetes and hypertension: a prospective study of US female nurses. Arch Dermatol. 2009;145(4):379–382.

63.

Brauchli YB, Jick SS, Meier CR. Psoriasis and the risk of incident diabetes mellitus: a population-based study. Br J Dermatol. 2008;159(6):1331–1337.

64.

Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. 2005;115(5):1111–1119.

65.

Azfar RS, Seminara NM, Shin DB, Troxel AB, Margolis DJ, Gelfand JM. Increased risk of diabetes mellitus and likelihood of receiving diabetes mellitus treatment in patients with psoriasis. Arch Dermatol. 2012;148(9):995–1000.

66.

Al-Mutairi N, Al-Farag S, Al-Mutairi A, Al-Shiltawy M. Comorbidities associated with psoriasis: an experience from the Middle East. J Dermatol. 2010;37(2):146–155.

67.

Farrokhi F, Taylor HC, McBride NM. Etanercept-induced hypoglycemia and improved glycemic control in a patient with type 2 diabetes. Endocr Pract. 2011;17(2):306–307.

68.

Wambier CG, Foss-Freitas MC, Paschoal RS, et al. Severe hypoglycemia after initiation of anti-tumor necrosis factor therapy with etanercept in a patient with generalized pustular psoriasis and type 2 diabetes mellitus. J Am Acad Dermatol. 2009;60(5):883–885.

69.

Cheung D, Bryer-Ash M. Persistent hypoglycemia in a patient with diabetes taking etanercept for the treatment of psoriasis. J Am Acad Dermatol. 2009;60(6):1032–1036.

70.

Marra M, Campanati A, Testa R, et al. Effect of etanercept on insulin sensitivity in nine patients with psoriasis. Int J Immunopathol Pharmacol. 2007;20(4):731–736.

71.

Morikang E, Benson SC, Kurtz TW, Pershadsingh HA. Effects of thiazolidinediones on growth and differentiation of human aorta and coronary myocytes. Am J Hypertens. 1997;10(4 Pt 1):440–446.

72.

Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature. 1998;391(6662):79–82.

73.

Ellis CN, Varani J, Fisher GJ, et al. Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation. Arch Dermatol. 2000;136(5):609–616.

74.

Malhotra A, Shafiq N, Rajagopalan S, Dogra S, Malhotra S. Thiazolidinediones for plaque psoriasis: a systematic review and meta-analysis. Evid Based Med. 2012;17(6):171–176.

75.

Huskicć J, Alendar F. Tissue angiotensin-converting enzyme in patients with various clinical forms of psoriasis. Bosn J Basic Med Sci. 2007;7(2):103–106.

76.

Ena P, Madeddu P, Glorioso N, Cerimele D, Rappelli A. High prevalence of cardiovascular diseases and enhanced activity of the renin-angiotensin system in psoriatic patients. Acta Cardiol. 1985;40(2):199–205.

77.

Ryder KW, Epinette WW, Jay SJ, Ransburg RC, Glick MR. Serum angiotensin converting enzyme activity in patients with psoriasis. Clin Chim Acta. 1985;153(2):143–146.

78.

Liu T, Han Y, Lu L. Angiotensin-converting enzyme gene polymorphisms and the risk of psoriasis: a meta-analysis. Clin Exp Dermatol. 2013;38(4):352–358; quiz 359.

79.

Armstrong AW, Harskamp CT, Armstrong EJ. The association between psoriasis and hypertension: a systematic review and meta-analysis of observational studies. J Hypertens. 2013;31(3):433–442; discussion 442–443.

80.

Sowers JR. Hypertension, angiotensin II, and oxidative stress. N Engl J Med. 2002;346(25):1999–2001.

81.

Armstrong AW, Voyles SV, Armstrong EJ, Fuller EN, Rutledge JC. Angiogenesis and oxidative stress: common mechanisms linking psoriasis with atherosclerosis. J Dermatol Sci. 2011;63(1):1–9.

82.

Cohen AD, Weitzman D, Dreiher J. Psoriasis and hypertension: a case-control study. Acta Derm Venereol. 2010;90(1):23–26.

83.

Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB, Gelfand JM. Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol. 2006;55(5):829–835.

84.

Robert N, Wong GW, Wright JM. Effect of cyclosporine on blood pressure. Cochrane Database Syst Rev. 2010;(1):CD007893.

85.

Waqar S, Sarkar PK. Exacerbation of psoriasis with beta-blocker therapy. CMAJ. 2009;181(1–2):60.

86.

O’Brien M, Koo J. The mechanism of lithium and beta-blocking agents in inducing and exacerbating psoriasis. J Drugs Dermatol. 2006;5(5):426–432.

87.

Wilson PW. Established risk factors and coronary artery disease: the Framingham Study. Am J Hypertens. 1994;7(7 Pt 2):7S–12S.

88.

Genest JJ Jr, Martin-Munley SS, McNamara JR, et al. Familial lipoprotein disorders in patients with premature coronary artery disease. Circulation. 1992;85(6):2025–2033.

89.

Manninen V, Tenkanen L, Koskinen P, et al. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. Circulation. 1992;85(1):37–45.

90.

Miller M, Seidler A, Moalemi A, Pearson TA. Normal triglyceride levels and coronary artery disease events: the Baltimore Coronary Observational Long-Term Study. J Am Coll Cardiol. 1998;31(6):1252–1257.

91.

Libby P. Inflammation in atherosclerosis. Nature. 2002;420(6917):868–874.

92.

Ribatti D, Levi-Schaffer F, Kovanen PT. Inflammatory angiogenesis in atherogenesis – a double-edged sword. Ann Med. 2008;40(8):606–621.

93.

Feingold KR, Marshall M, Gulli R, Moser AH, Grunfeld C. Effect of endotoxin and cytokines on lipoprotein lipase activity in mice. Arterioscler Thromb. 1994;14(11):1866–1872.

94.

Greenberg AS, Nordan RP, McIntosh J, Calvo JC, Scow RO, Jablons D. Interleukin 6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3-L1 adipocytes: a possible role for interleukin 6 in cancer cachexia. Cancer Res. 1992;52(15):4113–4116.

95.

Beutler BA, Cerami A. Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells. J Immunol. 1985;135(6):3969–3971.

96.

Feingold KR, Grunfeld C. Role of cytokines in inducing hyperlipidemia. Diabetes. 1992;41 Suppl 2:97–101.

97.

Memon RA, Grunfeld C, Moser AH, Feingold KR. Tumor necrosis factor mediates the effects of endotoxin on cholesterol and triglyceride metabolism in mice. Endocrinology. 1993;132(5):2246–2253.

98.

Rashmi R, Rao KSJ, Basavaraj KH. A comprehensive review of biomarkers in psoriasis. Clin Exp Dermatol. 2009;34(6):658–663.

99.

Rocha-Pereira P, Santos-Silva A, Rebelo I, Figueiredo A, Quintanilha A, Teixeira F. Dislipidemia and oxidative stress in mild and in severe psoriasis as a risk for cardiovascular disease. Clin Chim Acta. 2001;303(1–2):33–39.

100.

Tekin NS, Tekin IO, Barut F, Sipahi EY. Accumulation of oxidized low-density lipoprotein in psoriatic skin and changes of plasma lipid levels in psoriatic patients. Mediators Inflamm. 2007;2007:78454.

101.

Ma C, Harskamp CT, Armstrong EJ, Armstrong AW. The association between psoriasis and dyslipidaemia: a systematic review. Br J Dermatol. 2013;168(3):486–495.

102.

Bacchetti T, Campanati A, Ferretti G, Simonetti O, Liberati G, Offidani AM. Oxidative stress and psoriasis: the effect of antitumour necrosis factor-α inhibitor treatment. Br J Dermatol. 2013;168(5):984–989.

103.

Jamnitski A, Levels JH, van den Oever IA, Nurmohamed MT. High-density lipoprotein profiling changes in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors: a cohort study. J Rheumatol. 2013;40(6):825–830.

104.

Vis M, Nurmohamed MT, Wolbink G, et al. Short term effects of infliximab on the lipid profile in patients with rheumatoid arthritis. J Rheumatol. 2005;32(2):252–255.

105.

Kiortsis DN, Mavridis AK, Filippatos TD, Vasakos S, Nikas SN, Drosos AA. Effects of infliximab treatment on lipoprotein profile in patients with rheumatoid arthritis and ankylosing spondylitis. J Rheumatol. 2006;33(5):921–923.

106.

Tam LS, Tomlinson B, Chu TT, Li TK, Li EK. Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis. Clin Rheumatol. 2007;26(9):1495–1498.

107.

Mathieu S, Dubost JJ, Tournadre A, Malochet-Guinamand S, Ristori JM, Soubrier M. Effects of 14 weeks of TNF alpha blockade treatment on lipid profile in ankylosing spondylitis. Joint Bone Spine. 2010;77(1):50–52.

108.

Lestre S, Diamantino F, Veloso L, Fidalgo A, Ferreira A. Effects of etanercept treatment on lipid profile in patients with moderate-to-severe chronic plaque psoriasis: a retrospective cohort study. Eur J Dermatol. 2011;21(6):916–920.

109.

Corbetta S, Angioni R, Cattaneo A, Beck-Peccoz P, Spada A. Effects of retinoid therapy on insulin sensitivity, lipid profile and circulating adipocytokines. Eur J Endocrinol. 2006;154(1):83–86. doi:10.1530/eje.1.02057

110.

Gupta AK, Goldfarb MT, Ellis CN, Voorhees JJ. Side-effect profile of acitretin therapy in psoriasis. J Am Acad Dermatol. 1989;20(6):1088–1093.

111.

Vahlquist A, Törmä H. Retinoids and keratinization. Current concepts. Int J Dermatol. 1988;27(2):81–95.

112.

Ellis CN, Kang S, Vinik AI, Grekin RC, Cunningham WJ, Voorhees JJ. Glucose and insulin responses are improved in patients with psoriasis during therapy with etretinate. Arch Dermatol. 1987;123(4):471–475.

113.

Zech LA, Gross EG, Peck GL, Brewer HB. Changes in plasma cholesterol and triglyceride levels after treatment with oral isotretinoin. A prospective study. Arch Dermatol. 1983;119(12):987–993.

114.

Mantel-Teeuwisse AK, Kloosterman JM, Maitland-van der Zee AH, Klungel OH, Porsius AJ, de Boer A. Drug-Induced lipid changes: a review of the unintended effects of some commonly used drugs on serum lipid levels. Drug Saf. 2001;24(6):443–456.

115.

Grossman RM, Delaney RJ, Brinton EA, Carter DM, Gottlieb AB. Hypertriglyceridemia in patients with psoriasis treated with cyclosporine. J Am Acad Dermatol. 1991;25(4):648–651.

116.

Rajpara AN, Goldner R, Gaspari A. Psoriasis: can statins play a dual role? Dermatol Online J. 2010;16(2):2.

117.

Hilgendorff A, Muth H, Parviz B, et al. Statins differ in their ability to block NF-kappaB activation in human blood monocytes. Int J Clin Pharmacol Ther. 2003;41(9):397–401.

118.

Brauchli YB, Jick SS, Meier CR. Statin use and risk of first-time psoriasis diagnosis. J Am Acad Dermatol. 2011;65(1):77–83.

119.

Jacobi TC, Highet A. A clinical dilemma while treating hypercholesterolaemia in psoriasis. Br J Dermatol. 2003;149(6):1305–1306.

120.

Shirinsky IV, Shirinsky VS. Efficacy of simvastatin in plaque psoriasis: a pilot study. J Am Acad Dermatol. 2007;57(3):529–531.

121.

Fisher DA, Elias PM, LeBoit PL. Exacerbation of psoriasis by the hypolipidemic agent, gemfibrozil. Arch Dermatol. 1988;124(6):854–855.

122.

Milavec-Puretić V, Mance M, Ceović R, Lipozenčić J. Drug induced psoriasis. Acta Dermatovenerol Croat. 2011;19(1):39–42.

123.

Armstrong AW, Harskamp CT, Armstrong EJ. Psoriasis and metabolic syndrome: a systematic review and meta-analysis of observational studies. J Am Acad Dermatol. 2013;68(4):654–662.

124.

Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002;287(3):356–359.

125.

Hu G, Qiao Q, Tuomilehto J, et al. Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women. Arch Intern Med. 2004;164(10):1066–1076.

126.

Gisondi P, Tessari G, Conti A, et al. Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based case-control study. Br J Dermatol. 2007;157(1):68–73.

127.

McCullough AJ. Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol. 2006;40 Suppl 1:S17–S29.

128.

Kotronen A, Yki-Järvinen H. Fatty liver: a novel component of the metabolic syndrome. Arterioscler Thromb Vasc Biol. 2008;28(1):27–38.

129.

Marchesini G, Bugianesi E, Forlani G, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology. 2003;37(4):917–923.

130.

Wenk KS, Arrington KC, Ehrlich A. Psoriasis and non-alcoholic fatty liver disease. J Eur Acad Dermatol Venereol. 2011;25(4):383–391.

131.

Miele L, Vallone S, Cefalo C, et al. Prevalence, characteristics and severity of non-alcoholic fatty liver disease in patients with chronic plaque psoriasis. J Hepatol. 2009;51(4):778–786.

132.

Gisondi P, Targher G, Zoppini G, Girolomoni G. Non-alcoholic fatty liver disease in patients with chronic plaque psoriasis. J Hepatol. 2009;51(4):758–764.

133.

Nyfors A. Liver biopsies from psoriatics related to methotrexate therapy. 3. Findings in post-methotrexate liver biopsies from 160 psoriatics. Acta Pathol Microbiol Scand A. 1977;85(4):511–518.

134.

Weinblatt ME, Coblyn JS, Fox DA, et al. Efficacy of low-dose methotrexate in rheumatoid arthritis. N Engl J Med. 1985;312(13):818–822.

135.

Leonard PA, Clegg DO, Carson CC, Cannon GW, Egger MJ, Ward JR. Low dose pulse methotrexate in rheumatoid arthritis: an 8-year experience with hepatotoxicity. Clin Rheumatol. 1987;6(4):575–582.

136.

Prey S, Paul C. Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review. Br J Dermatol. 2009;160(3):622–628.

137.

van Ede AE, Laan RF, Rood MJ, et al. Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2001;44(7):1515–1524.

138.

Roenigk HH Jr, Auerbach R, Maibach H, Weinstein G, Lebwohl M. Methotrexate in psoriasis: consensus conference. J Am Acad Dermatol. 1998;38(3):478–485.

139.

Menter A, Korman NJ, Elmets CA, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: section 4. Guidelines of care for the management and treatment of psoriasis with traditional systemic agents. J Am Acad Dermatol. 2009;61(3):451–485.

140.

Kalb RE, Strober B, Weinstein G, Lebwohl M. Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference. J Am Acad Dermatol. 2009;60(5):824–837.

141.

Frentz G, Olsen JH. Malignant tumours and psoriasis: a follow-up study. Br J Dermatol. 1999;140(2):237–242.

142.

Hannuksela-Svahn A, Pukkala E, Läärä E, Poikolainen K, Karvonen J. Psoriasis, its treatment, and cancer in a cohort of Finnish patients. J Invest Dermatol. 2000;114(3):587–590.

143.

Boffetta P, Gridley G, Lindelöf B. Cancer risk in a population-based cohort of patients hospitalized for psoriasis in Sweden. J Invest Dermatol. 2001;117(6):1531–1537.

144.

Stern RS, Lange R. Non-melanoma skin cancer occurring in patients treated with PUVA five to ten years after first treatment. J Invest Dermatol. 1988;91(2):120–124.

145.

Stern RS, Laird N. The carcinogenic risk of treatments for severe psoriasis. Photochemotherapy Follow-up Study. Cancer. 1994;73(11):2759–2764.

146.

Stern RS. Lymphoma risk in psoriasis: results of the PUVA follow-up study. Arch Dermatol. 2006;142(9):1132–1135.

147.

Stern RS, Nichols KT, Väkevä LH. Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA Follow-Up Study. N Engl J Med. 1997;336(15):1041–1045.

148.

Stern RS; PUVA Follow up Study. The risk of melanoma in association with long-term exposure to PUVA. J Am Acad Dermatol. 2001;44(5):755–761.

149.

Krishnamoorthy S, Honn KV. Inflammation and disease progression. Cancer Metastasis Rev. 2006;25(3):481–491.

150.

Gelfand JM, Shin DB, Neimann AL, Wang X, Margolis DJ, Troxel AB. The risk of lymphoma in patients with psoriasis. J Invest Dermatol. 2006;126(10):2194–2201.

151.

Gridley G, McLaughlin JK, Ekbom A, et al. Incidence of cancer among patients with rheumatoid arthritis. J Natl Cancer Inst. 1993;85(4):307–311.

152.

Ekström K, Hjalgrim H, Brandt L, et al. Risk of malignant lymphomas in patients with rheumatoid arthritis and in their first-degree relatives. Arthritis Rheum. 2003;48(4):963–970.

153.

Brauchli YB, Jick SS, Miret M, Meier CR. Psoriasis and risk of incident cancer: an inception cohort study with a nested case-control analysis. J Invest Dermatol. 2009;129(11):2604–2612.

154.

Hayes J, Koo J. Psoriasis: depression, anxiety, smoking, and drinking habits. Dermatol Ther. 2010;23(2):174–180.

155.

Gerdes S, Zahl VA, Weichenthal M, Mrowietz U. Smoking and alcohol intake in severely affected patients with psoriasis in Germany. Dermatology. 2010;220(1):38–43.

156.

Lee MS, Lin RY, Chang YT, Lai MS. The risk of developing non-melanoma skin cancer, lymphoma and melanoma in patients with psoriasis in Taiwan: a 10-year, population-based cohort study. Int J Dermatol. 2012;51(12):1454–1460.

157.

Stern RS; PUVA Follow-Up Study. The risk of squamous cell and basal cell cancer associated with psoralen and ultraviolet A therapy: a 30-year prospective study. J Am Acad Dermatol. 2012;66(4):553–562.

158.

Paul CF, Ho VC, McGeown C, et al. Risk of malignancies in psoriasis patients treated with cyclosporine: a 5 y cohort study. J Invest Dermatol. 2003;120(2):211–216.

159.

Colombo MD, Cassano N, Bellia G, Vena GA. Cyclosporine regimens in plaque psoriasis: an overview with special emphasis on dose, duration, and old and new treatment approaches. ScientificWorld Journal. 2013;2013:805705.

160.

Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA. 2006;295(19):2275–2285.

161.

Bongartz T, Warren FC, Mines D, Matteson EL, Abrams KR, Sutton AJ. Etanercept therapy in rheumatoid arthritis and the risk of malignancies: a systematic review and individual patient data meta-analysis of randomised controlled trials. Ann Rheum Dis. 2009;68(7):1177–1183.

162.

Leombruno JP, Einarson TR, Keystone EC. The safety of anti-tumour necrosis factor treatments in rheumatoid arthritis: meta and exposure-adjusted pooled analyses of serious adverse events. Ann Rheum Dis. 2009;68(7):1136–1145.

163.

Dommasch ED, Abuabara K, Shin DB, Nguyen J, Troxel AB, Gelfand JM. The risk of infection and malignancy with tumor necrosis factor antagonists in adult patients with psoriatic disease: a systematic review and meta-analysis of randomized controlled trials. J Am Acad Dermatol. 2011;64(6):1035–1050.

164.

Weiss SC, Kimball AB, Liewehr DJ, Blauvelt A, Turner ML, Emanuel EJ. Quantifying the harmful effect of psoriasis on health-related quality of life. J Am Acad Dermatol. 2002;47(4):512–518.

165.

Gupta MA, Gupta AK. The Psoriasis Life Stress Inventory: a preliminary index of psoriasis-related stress. Acta Derm Venereol. 1995;75(3):240–243.

166.

Gupta MA, Gupta AK, Watteel GN. Perceived deprivation of social touch in psoriasis is associated with greater psychologic morbidity: an index of the stigma experience in dermatologic disorders. Cutis. 1998;61(6):339–342.

167.

Devrimci-Ozguven H, Kundakci TN, Kumbasar H, Boyvat A. The depression, anxiety, life satisfaction and affective expression levels in psoriasis patients. J Eur Acad Dermatol Venereol. 2000;14(4):267–271.

168.

Fortune DG, Main CJ, O’Sullivan TM, Griffiths CE. Assessing illness-related stress in psoriasis: the psychometric properties of the Psoriasis Life Stress Inventory. J Psychosom Res. 1997;42(5):467–475.

169.

Schiepers OJG, Wichers MC, Maes M. Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(2):201–217.

170.

Scharloo M, Kaptein AA, Weinman J, Bergman W, Vermeer BJ, Rooijmans HG. Patients’ illness perceptions and coping as predictors of functional status in psoriasis: a 1-year follow-up. Br J Dermatol. 2000;142(5):899–907.

171.

Gupta MA, Gupta AK. Depression and suicidal ideation in dermatology patients with acne, alopecia areata, atopic dermatitis and psoriasis. Br J Dermatol. 1998;139(5):846–850.

172.

Fortune DG, Richards HL, Kirby B, Bowcock S, Main CJ, Griffiths CE. A cognitive-behavioural symptom management programme as an adjunct in psoriasis therapy. Br J Dermatol. 2002;146(3):458–465.

173.

Tesmer LA, Lundy SK, Sarkar S, Fox DA. Th17 cells in human disease. Immunol Rev. 2008;223:87–113.

174.

Wolf N, Quaranta M, Prescott NJ, et al. Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease. J Med Genet. 2008;45(2):114–116.

175.

Capon F, Di Meglio P, Szaub J, et al. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Hum Genet. 2007;122(2):201–206.

176.

Cargill M, Schrodi SJ, Chang M, et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 2007;80(2):273–290.

177.

Nair RP, Ruether A, Stuart PE, et al. Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol. 2008;128(7):1653–1661.

178.

Aslanidis S, Pyrpasopoulou A, Douma S, Triantafyllou A. Tumor necrosis factor-a antagonist-induced psoriasis: yet another paradox in medicine. Clin Rheumatol. 2008;27(3):377–380.

179.

Ahmad T, Marshall SE, Jewell D. Genetics of inflammatory bowel disease: the role of the HLA complex. World J Gastroenterol. 2006;12(23):3628–3635.

180.

Cohen AD, Dreiher J, Birkenfeld S. Psoriasis associated with ulcerative colitis and Crohn’s disease. J Eur Acad Dermatol Venereol. 2009;23(5):561–565.

181.

Li WQ, Han JL, Chan AT, Qureshi AA. Psoriasis, psoriatic arthritis and increased risk of incident Crohn’s disease in US women. Ann Rheum Dis. 2013;72(7):1200–1205.

182.

Makredes M, Robinson D Jr, Bala M, Kimball AB. The burden of autoimmune disease: a comparison of prevalence ratios in patients with psoriatic arthritis and psoriasis. J Am Acad Dermatol. 2009;61(3):405–410.

183.

Birkenfeld S, Dreiher J, Weitzman D, Cohen AD. Coeliac disease associated with psoriasis. Br J Dermatol. 2009;161(6):1331–1334.

184.

Wu JJ, Nguyen TU, Poon KY, Herrinton LJ. The association of psoriasis with autoimmune diseases. J Am Acad Dermatol. 2012;67(5):924–930.

185.

Angelucci E, Cocco A, Viscido A, Vernia P, Caprilli R. Another paradox in Crohn’s disease: new onset of psoriasis in a patient receiving tumor necrosis factor-alpha antagonist. Inflamm Bowel Dis. 2007;13(8):1059–1061.

186.

Severs GA, Lawlor TH, Purcell SM, Adler DJ, Thompson R. Cutaneous adverse reaction to infliximab: report of psoriasis developing in 3 patients. Cutis. 2007;80(3):231–237.

187.

Wollina U, Hansel G, Koch A, Schönlebe J, Köstler E, Haroske G. Tumor necrosis factor-alpha inhibitor-induced psoriasis or psoriasiform exanthemata: first 120 cases from the literature including a series of six new patients. Am J Clin Dermatol. 2008;9(1):1–14.

188.

Aeberli D, Seitz M, Jüni P, Villiger PM. Increase of peripheral CXCR3 positive T lymphocytes upon treatment of RA patients with TNF-alpha inhibitors. Rheumatology (Oxford). 2005;44(2):172–175.

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