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Psoriasis and comorbidities: links and risks

Authors Ni C, Chiu M

Received 3 January 2014

Accepted for publication 19 February 2014

Published 17 April 2014 Volume 2014:7 Pages 119—132

DOI https://doi.org/10.2147/CCID.S44843

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Catherine Ni, Melvin W Chiu

Division of Dermatology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA

Abstract: Psoriasis is a chronic inflammatory skin disease affecting approximately 2% of the population worldwide. In the past decade, many studies have drawn attention to comorbid conditions in psoriasis. This literature review examines the epidemiological evidence, pathophysiological commonalities, and therapeutic implications for different comorbidities of psoriasis. Cardiovascular disease, obesity, diabetes, hypertension, dyslipidemia, metabolic syndrome, nonalcoholic fatty liver disease, cancer, anxiety and depression, and inflammatory bowel disease have been found at a higher prevalence in psoriasis patients compared to the general population. Because of the wide range of comorbid conditions associated with psoriasis, comprehensive screening and treatment must be implemented to most effectively manage psoriasis patients.

Keywords: cardiovascular, metabolic syndrome


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