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Prognostic and clinicopathological significance of DEPTOR expression in cancer patients: a meta-analysis

Authors Hu B, Shi D, Lv X, Wu F, Chen S, Shao Z

Received 6 March 2018

Accepted for publication 22 June 2018

Published 22 August 2018 Volume 2018:11 Pages 5083—5092

DOI https://doi.org/10.2147/OTT.S167355

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ashok Kumar Pandurangan

Peer reviewer comments 3

Editor who approved publication: Dr Yao Dai


Binwu Hu,1 Deyao Shi,1 Xiao Lv,1 Fashuai Wu,1 Songfeng Chen,2 Zengwu Shao1

1Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; 2Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Background: DEP domain containing mammalian target of rapamycin (mTOR)-interacting protein (DEPTOR), a recently discovered endogenous inhibitor of mTOR, has been found to be abnormally expressed in various tumors. Recent studies have demonstrated that DEPTOR could serve as a potential prognostic biomarker in several kinds of cancer. However, the prognostic value of DEPTOR is still controversial so far.
Patients and methods: PubMed, Embase and Web of Science were systematically searched to obtain all relevant articles about the prognostic value of DEPTOR in cancer patients. ORs or HRs with corresponding 95% CIs were pooled to estimate the association between DEPTOR expression and the clinicopathological characteristics or survival of cancer patients.
Results: A total of nine eligible studies with 974 cancer patients were included in our meta-analysis. Our results demonstrated that the expression of DEPTOR was not associated with the overall survival (OS) (pooled HR=0.795, 95% CI=0.252–2.509) and event-free survival (EFS) (pooled HR=1.244, 95% CI=0.543–2.848) in cancer patients. Furthermore, subgroup analysis divided by sample size, type of cancer, Newcastle–Ottawa Scale (NOS) score and evaluation of DEPTOR expression showed identical prognostic value. In addition, our analysis also revealed that there was no significant association between expression level of DEPTOR and clinicopathological characteristics, such as tumor stage, lymph node metastasis, differentiation grade and gender.
Conclusion: Our meta-analysis suggested that despite the fact that DEPTOR could be overexpressed or downregulated in cancer patients, it might not be a potential marker to predict the prognosis of cancer patients.

Keywords:
DEPTOR, cancer, overall survival, event-free survival, meta-analysis

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