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Preliminary pilot fMRI study of neuropostural optimization with a noninvasive asymmetric radioelectric brain stimulation protocol in functional dysmetria

Authors Mura, Castagna A, Fontani V, Rinaldi S

Received 16 January 2012

Accepted for publication 2 March 2012

Published 4 April 2012 Volume 2012:8 Pages 149—154

DOI https://doi.org/10.2147/NDT.S29971

Review by Single-blind

Peer reviewer comments 3

Marco Mura1, Alessandro Castagna2, Vania Fontani2, Salvatore Rinaldi2

1Institute of Radiology, University of Cagliari, 2Rinaldi Fontani Institute – Department of Neuro Psycho Physical Optimization, Florence, Italy

Purpose: This study assessed changes in functional dysmetria (FD) and in brain activation observable by functional magnetic resonance imaging (fMRI) during a leg flexion-extension motor task following brain stimulation with a single radioelectric asymmetric conveyer (REAC) pulse, according to the precisely defined neuropostural optimization (NPO) protocol.
Population and methods: Ten healthy volunteers were assessed using fMRI conducted during a simple motor task before and immediately after delivery of a single REAC-NPO pulse. The motor task consisted of a flexion-extension movement of the legs with the knees bent. FD signs and brain activation patterns were compared before and after REAC-NPO.
Results: A single 250-millisecond REAC-NPO treatment alleviated FD, as evidenced by patellar asymmetry during a sit-up motion, and modulated activity patterns in the brain, particularly in the cerebellum, during the performance of the motor task.
Conclusion: Activity in brain areas involved in motor control and coordination, including the cerebellum, is altered by administration of a REAC-NPO treatment and this effect is accompanied by an alleviation of FD.

Keywords: motor behavior, motor control, cerebellum, dysmetria, functional dysmetria, fluctuating asymmetry

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