Back to Journals » International Journal of Women's Health » Volume 8

Pregnancy in women with thalassemia: challenges and solutions

Authors Petrakos G, Andriopoulos P, Tsironi M

Received 5 April 2016

Accepted for publication 14 July 2016

Published 8 September 2016 Volume 2016:8 Pages 441—451

DOI https://doi.org/10.2147/IJWH.S89308

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Leyla Bahar

Peer reviewer comments 2

Editor who approved publication: Professor Elie Al-Chaer


George Petrakos, Panagiotis Andriopoulos, Maria Tsironi

Department of Nursing, University of Peloponnese, Sparta, Greece

Abstract: Advances in treatment of thalassemia have led to the aging of thalassemic patients, and consequently concern about successful reproductive outcome is augmented. Although women with thalassemia intermedia only were considered competent of achieving pregnancy, case series reveal the willingness of both thalassemia major and thalassemia intermedia women to have a family. Pregnancy in general is characterized by dynamic multiple-system changes and increased susceptibility to oxidative stress, while homozygous, transfusion-dependent, β-thalassemia patients manifest cardiac, hepatic, endocrine, and metabolic disorders attributable to chronic anoxia and iron overload and thalassemia intermedia, usually nontransfused, is associated with augmented risk of thromboembolic events. Pregnancy in thalassemia should be considered a high risk for both mother and fetus, and favorable outcomes are the result of continuous preconception, antenatal, and postpartum assessment and management by a team of thalassemia experts.

Keywords: thalassemia, pregnancy, chelation, transfusion, iron

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]