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Predictive value of high sensitivity C-reactive protein on progression to heart failure occurring after the first myocardial infarction

Authors Al Aseri ZA, Habib SS, Marzouk A

Received 16 December 2018

Accepted for publication 1 May 2019

Published 15 July 2019 Volume 2019:15 Pages 221—227


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Konstantinos Tziomalos

Zohair A Al Aseri,1 Syed Shahid Habib,2 Ameer Marzouk3

1Department of Emergency Medicine, King Saud University & Medical City, Riyadh, Saudi Arabia; 2Department of Physiology, King Saud University & Medical City, Riyadh, Saudi Arabia; 3College of Medicine Research Center, King Saud University & Medical City, Riyadh, Saudi Arabia

Background: High sensitivity C-reactive protein (hsCRP) predicts myocardial dysfunction after acute coronary syndromes. We aimed to study the association of hsCRP estimation at first acute myocardial infarction (AMI) with myocardial dysfunction and heart failure.
Methods: This research was carried out at the Department of Physiology and Department of Emergency Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia. In this prospective study, 227 patients were studied. hsCRP levels were estimated when patients came to the emergency department at AMI, 7 days post AMI, and at 12 weeks of follow up after AMI. The outcome was change in myocardial functions, especially heart failure, 12 months after the attack.
Results: Based on a cutoff mean value of hsCRP levels at admission (10.05±12.68 mg/L), patients were grouped into high and low C-reactive protein (CRP.) The ejection fraction was significantly lower at follow up in the high CRP group (37.29±12.97) compared to the low CRP group (43.85±11.77, p<0.0198). hsCRP had significant inverse correlation with left ventricular ejection fraction (r=−0.283, p<0.01). About 38.1% patients showed heart failure, with 23.6% in the high CRP group and 14.5% in the low CRP group (OR 2.4, p=0.028). Receiver operating characteristic curve analysis showed that CRP levels at AMI had a specificity of 79% and sensitivity of 83% to predict heart failure.
Conclusion: A high hsCRP level measured at first AMI predicts myocardial dysfunction and heart failure. It is suggested that hsCRP plays an important role in the development of heart failure after myocardial infarction.

Keywords: high sensitivity C-reactive protein, Lipoprotein(a), heart failure, acute myocardial infarction, ejection fraction

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