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Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: An Updated Review of Current Preventive Strategies

Authors Bhatt H

Received 19 August 2020

Accepted for publication 13 January 2021

Published 2 February 2021 Volume 2021:14 Pages 27—32

DOI https://doi.org/10.2147/CEG.S276361

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Wing-Kin Syn


Harshil Bhatt1,2

1Goshen Hospital, Goshen, IN, USA; 2Indiana University School of Medicine, South Bend, IN, USA

Correspondence: Harshil Bhatt
Goshen Hospital, 200 High Park Ave, Goshen, IN 46526, USA
Tel +1 574-364-2510
Fax +1 844-850-7282
Email harshilbhatt@ymail.com

Abstract: Pancreatitis is a serious complication of endoscopic retrograde cholangiopancreatography, with incidence rates as high as 16% in some centers. Recent studies have also shown an upward trend in hospitalization due to endoscopic retrograde cholangiopancreatography-related pancreatitis. Early interventions taken before, during, and after the procedure can significantly reduce the risk of pancreatitis and decrease morbidity and mortality of the patients. To select appropriate patients for endoscopic retrograde cholangiopancreatography, in-depth knowledge of the patient-related and procedure-related risk factors is required. This updated clinical review outlines various pharmacological agents and surgical methods used for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis. Current evidence supports the use of rectal non-steroidal anti-inflammatory drugs and pancreatic stent placement as an effective preventive strategy. Further research is needed to compare these preventive modalities to improve patient outcomes after endoscopic retrograde cholangiopancreatography.

Keywords: ERCP, post-ERCP pancreatitis, endoscopic retrograde cholangiopancreatography, rectal non-steroidal anti-inflammatory drugs, pancreatic stent

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