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Polyaniline-coated upconversion nanoparticles with upconverting luminescent and photothermal conversion properties for photothermal cancer therapy

Authors Xing Y, Li L, Ai X, Fu L

Received 30 September 2015

Accepted for publication 12 January 2016

Published 2 September 2016 Volume 2016:11 Pages 4327—4338

DOI https://doi.org/10.2147/IJN.S97441

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 7

Editor who approved publication: Dr Lei Yang


Yadong Xing, Luoyuan Li, Xicheng Ai, Limin Fu

Department of Chemistry, Renmin University of China, Beijing, People’s Republic of China


Abstract: In this study, we developed a nanosystem based on upconversion nanoparticles (UCNPs) coated with a layer of polyaniline nanoparticles (PANPs). The UCNP induces upconversion luminescence for imaging and photothermal conversion properties are due to PANPs. In vitro experiments showed that the UCNPs-PANPs were nontoxic to cells even at a high concentration (800 µg mL-1). Blood analysis and histological experiments demonstrated that the UCNPs-PANPs exhibited no apparent toxicity in mice in vivo. Besides their efficacy in photothermal cancer cell ablation, the UCNP-PANP nanosystem was found to achieve an effective in vivo tumor ablation effect after irradiation using an 808 nm laser. These results demonstrate the potential of the hybrid nanocomposites for use in imaging-guided photothermal therapy.

Keywords: upconversion nanoparticles, polyaniline, upconversion luminescence, photothermal therapy

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