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Plasma Long Non-Coding RNA RP11-438N5.3 Level for Non-Small Cell Lung Cancer Diagnosis [Letter]

Authors Yang CQ, Zhang GM

Received 22 March 2020

Accepted for publication 25 March 2020

Published 21 April 2020 Volume 2020:12 Pages 2663—2664

DOI https://doi.org/10.2147/CMAR.S255036

Checked for plagiarism Yes

Editor who approved publication: Dr Chien-Feng Li


Chun-Qiu Yang, 1 Guo-Ming Zhang 2

1Department of Laboratory Medicine, Taihe County People’s Hospital, Fuyang 236600, People’s Republic of China; 2Department of Laboratory Medicine, Shuyang People’s Hospital, Shuyang Hospital Affiliated to Xuzhou Medical University, Shuyang 223600, People’s Republic of China

Correspondence: Guo-Ming Zhang
Department of Laboratory Medicine, Shuyang People’s Hospital, The Affiliated Shuyang Hospital of Xuzhou Medical University, Shuyang 223600, People’s Republic of China
Email gm@xzhmu.edu.cn


Chen et al 1 published an article entitled “Plasma Long Non-Coding RNA RP11-438N5.3 as a Novel Biomarker for Non-Small Cell Lung Cancer” in the Cancer Management and Research journal. To evaluate the diagnostic efficiency of Plasma level of RP11-438N5.3 for non-small-cell lung cancer (NCLC), the investigators enrolled  69 NCLC patients and 69 healthy controls in this study. Plasma level of RP11-438N5.3 was determined using quantitative reverse transcription PCR (qRT-PCR), and receiver operating characteristic (ROC) curve analysis was assessed to determine the diagnostic performance of Plasma level of RP11-438N5.3 level in NCLC. They found that Plasma level of RP11-438N5.3 level was significantly lower in NCLC patients than healthy controls and the area under ROC curve (AUC) is  0.814. Therefore, they concluded that the Plasma level of RP11-438N5.3 was a novel diagnostic biomarker for NCLC.

View the original paper by Chen and colleagues

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