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Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery

Authors Irfan MM, Shah SU, Khan IU, Munir MU, Khan NR, Shah KU, Rehman SU, Sohaib M, Basit HM, Mahmood S

Received 10 December 2020

Accepted for publication 21 January 2021

Published 16 February 2021 Volume 2021:16 Pages 1207—1220

DOI https://doi.org/10.2147/IJN.S296793

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Thomas J. Webster


Malik Muhammad Irfan,1,2 Shefaat Ullah Shah,1,2 Ikram Ullah Khan,3 Muhammad Usman Munir,4 Nauman Rahim Khan,1,2 Kifayat Ullah Shah,1 Saif Ur Rehman,5 Muhammad Sohaib,1,2 Hafiz Muhammad Basit,1,2 Saima Mahmood1,2

1Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, D.I. Khan, 29050, KPK, Pakistan; 2Gomal Centre for Skin/Regenerative Medicine and Drug Delivery Research (GCSRDDR), Faculty of Pharmacy, Gomal University, D.I. Khan, 29050, KPK, Pakistan; 3Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan; 4Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University Sakaka, Aljouf, 72388, Saudi Arabia; 5Department of Pharmacy, Faculty of Medical and Health Sciences, University of Poonch, Rawlakot, AJK, Pakistan

Correspondence: Shefaat Ullah Shah
Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, D.I. Khan, Pakistan
Tel +92-336-514 0 682
Email shefaatbu@gmail.com

Introduction: The current work aimed to formulate a novel chitosan-based finasteride nanosystem (FNS-NS) for skin delivery to optimize the drug availability in skin for a longer time and enhance ex vivo performance of finasteride against androgenic alopecia.
Methods: Both undecorated and chitosan decorated FNS-NSs were synthesized by a high energy emulsification technique. All the prepared nanosystems were further subjected to physicochemical characterizations like pH, viscosity, encapsulation efficiency, surface morphology and in vitro drug release behavior. The influence of the nanosystem on the drug permeation and retention in rat skin was examined using Franz diffusion cell apparatus.
Results: The droplet size of developed nanosystems ranged from 41 to 864 nm with a low polydispersity index. The zeta potential of the nanosystems was between -10 mV and +56 mV. This chitosan decorated nanosystem exhibited controlled drug release, ie about 78– 97% in 24 h. Among all the nanosystems, our chitosan decorated formulation (F5) had low drug permeation (16.35 μg/cm2) and higher drug retention (10.81 μg/cm2).
Conclusion: The abovementioned results demonstrate satisfactory in vitro drug release, skin retention profiles and ex vivo performance with chitosan decorated FNS-NS (F5). This optimized formulation could increase drug availability in skin and could become a promising carrier for topical delivery to treat androgenic alopecia.

Keywords: finasteride, nanosystem, solubility, chitosan, permeation, retention, androgenic alopecia

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