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Perioperative Exercise Therapy in Bariatric Surgery: Improving Patient Outcomes

Authors Pouwels S , Sanches EE , Cagiltay E , Severin R , Philips SA

Received 16 February 2020

Accepted for publication 7 May 2020

Published 25 May 2020 Volume 2020:13 Pages 1813—1823

DOI https://doi.org/10.2147/DMSO.S215157

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Juei-Tang Cheng



Sjaak Pouwels, 1 Elijah E Sanches, 1 Eylem Cagiltay, 2 Rich Severin, 3– 5 Shane A Philips 5, 6

1Department of Surgery, Haaglanden Medical Center, The Hague, the Netherlands; 2University of Health Sciences Turkey, Sultan Abdulhamid Han Education and Research Hospital, Department of Endocrinology and Metabolic Diseases, Istanbul, Uskudar, 34668, Turkey; 3Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA; 4Physical Therapy Program, Robbins College of Health and Human Sciences, Baylor University, Waco, TX, USA; 5Graduate Program in Rehabilitation Sciences, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA; 6Department of Physical Therapy, Integrative Physiologic Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA

Correspondence: Sjaak Pouwels
Department of Surgery, Haaglanden Medical Center, P.O. Box 432, 2501 CK, The Hague, the Netherlands
Email [email protected]

Abstract: Nowadays, obesity and related comorbidities like type 2 diabetes, hypertension, dyslipidaemia and obstructive sleep apnoea syndrome are considered one of the medical challenges of the 21st century. Even with the rise of bariatric and metabolic surgery, obesity and metabolic syndrome are reaching endemic proportions. Even in 2020, obesity is still a growing problem. There is increasing evidence that next to bariatric surgery, exercise interventions in the perioperative period could give extra beneficial effects. In this regard, effects on anthropometrics, cardiovascular risk factors and physical fitness. The aim of this review is to summarise effects of preoperative and postoperative exercise, tools for screening and directions for future research and implementations.

Keywords: obesity, exercise, bariatric surgery, metabolic surgery, postoperative outcomes

Corrigendum for this paper has been published

Introduction

Obesity and related comorbidities such as type 2 diabetes (T2DM), hypertension, dyslipidaemia and obstructive sleep apnoea syndrome (OSAS) are considered one of the medical challenges of the 21st century.1,2 Even with the rise of bariatric and metabolic surgery, obesity and metabolic syndrome are reaching endemic proportions and the proportion of the population with morbid obesity increases every year.3 Dietary and exercise interventions alone are not entirely successful in reaching significant and longstanding weight loss.4,5 Bariatric surgery is the only treatment for patients with obesity that has a longstanding effect on weight loss and the (possible) remission of obesity-related comorbidities4,5 Despite these proven long-term effects, bariatric surgery is still a “tool” achieving long-term weight loss. Therefore, a significant amount of patients show weight regain after a few years.6 Several studies have shown that the combination of bariatric surgery and dietary/exercise interventions could be beneficial in maintaining weight loss in the long term.7,8 In our opinion, a pivotal aspect is good and well-structured follow-up program.

In other surgical specialties, exercise training is often used to improve preoperative physical fitness a postoperative outcomes.811 Despite promising beneficial outcomes these perioperative exercise programs are barely used in bariatric surgical practice. There is a significant body of evidence that indicates that exercise is good for improving physical fitness, but also Quality of Life (QoL). A Cochrane review by Shaw et al12 showed a reduction of 1.5 kg that was contributed to exercise. These findings were substantiated by a systematic review of Livhits et al.13 They focused on physical training and obesity and found a 4% Excess Weight Loss (%EWL) contributable to the exercise intervention.13 Similar findings were seen in the study by Egberts et al.14 They found that exercise after bariatric surgery resulted in a body weight reduction of 3.6 kg.14 However, there is still no consensus on how to structure exercise programs in bariatric surgery. Often only exercise advice is given without a structured program.12 Assessing outcome measurements, without a structured program is problematic, since weight loss measurements are self-reported and are not objectively assessed. Secondly, there is no adequate description of physical activity and which exercises were done. Recently Pouwels et al7 tried to summarise what kind of exercise is beneficial in the perioperative period (in bariatric surgery) and also when patients should exercise. They concluded that there is a positive effect of peri-bariatric exercise on anthropometrics, cardiovascular risk factors and physical fitness. However no unanimous conclusions could be drawn, since there was a high heterogeneity level among exercise programs. The aim of this review is to summarise effects of preoperative and postoperative exercise, tools for screening and directions for future research and implementations.

Screening

Surgery, in general, has considerable effects on patients with regards to complications, mortality and physical capacity/functioning. These risks are also present in patients with obesity and patient’s before/after bariatric and metabolic surgery. To improve perioperative practices, improve logistics in the Operating Room and finally reduce complications and length of hospital stay the Enhanced Recovery after Surgery (ERAS) pathway was developed in the 1990s.15

These ERAS protocols were game changers in perioperative medicine and aimed to incorporate a multimodal and patient centred approach to surgical care. Initially developed for colorectal surgery, but it has been applied to all major surgical specialities.16 Also in primary and revisional bariatric surgery, extensive research has been done and ERAS or ERABS (Enhanced Recovery After Bariatric Surgery) has been implemented in the majority of hospitals worldwide.1720 These care pathways were designed to modify physiological and psychological responses to surgical trauma by integrating a range of evidence-based components into a standardised clinical pathway. The most important aspect is that all these reductions (e.g. reduction in complications, reduced length of hospital stay and healthcare cost reduction) were achieved without comprising the perioperative patient safety21 and were associated with lower healthcare costs.22 Ljungqvist et al16 wrote a landmark paper and they studied and defined the 24 core aspects of the ERAS protocol. Among these essential elements are smoking and alcohol cessation, a structured preoperative information and education regimen, preoperative carbohydrate treatment and prophylaxis against venous thrombo-embolisms and infections.16

All these core ERAS aspects are implemented in the ERABS protocols and can also be easily used in perioperative exercise programs in patients scheduled for bariatric and metabolic surgery. These exercise interventions have similarities with a new concept of prehabilitation in other surgical practices. They have the goal of improving physical functioning of the patient to endure the upcoming surgical procedure.23 These concepts were developed according to a wide variety of studies that indicate that a higher preoperative level of fitness is associated with a reduction in postoperative complications and an improved clinical outcome.2426

In this context, Orange et al27 and Minnella et al28 investigated and summarised the essential point for preparing patients for a surgical procedure. Among them; optimisation of nutritional status, psychological status and of course improving exercise capacity and physical functioning. Topal et al29 added one very important aspect, namely the improvement of comorbidities. This is essential since the bariatric surgical patients get older and have potentially more comorbidities with medication use. Table 1 gives an overview of the modifiable patient-related factors.

Table 1 Overview of the Modifiable Patient-Related Factors

Nutritional Assessment

Malnutrition is a serious and impactful problem in surgical practice that affects approximately two out of three patients.30,31 We can state that malnutrition is a possibly undertreated condition that often leads to surgical and non-surgical complications, in both the lean population and in patients with obesity.3234 The physiological response due to surgical stress triggers a cascade of processes from systemic inflammation, insulin and blood glucose abnormalities, significant changes in energy expenditure and secretion of hormones.35,36 This can lead to significant clinical sequelae like poor appetite, weight loss, and muscle mass wasting, and could lead to cachexia or sarcopenia.35,36 These symptoms or sequelae will eventually lead to a higher risk of postoperative complications, extended hospital stay, higher mortality and morbidity rates and finally an increase health-care costs.3537

Especially in the surgical oncology literature, there seems to be a clear relationship between nutrition, age, cancer, surgery and physical functioning.30,31,35,36,38 Therefore, nutritional assessment is an important part of bariatric surgical screening and prior to starting exercise programs.

Physical Fitness Assessment

The decrease in physical functioning due to obesity and the presence of comorbidities is an increasing worldwide problem.39 Physical/cardiorespiratory fitness (CRF) is a constant indicating the ability to meet the increase in oxygen consumption during daily activities, exercise and stress conditions.4042 This can be impaired by, for example, obesity, cancer, surgery, radiotherapy, chemotherapy, infection or hormone therapy.7,43,44

A significant body of evidence has shown that the level of preoperative physical function is a significant predictor for postoperative complications and mortality.4547 In light of this evidence, it has also been seen that a temporary functional decline is normal before, during and after hospitalization and after surgery.48 As stated earlier when these periods of inactivity prolong it has effects on muscle mass and the cardiopulmonary system. Eventually, muscle wasting will occur combined with possible cardiopulmonary deconditioning which will increase the risk of postoperative complications, mortality and psychological distress. These findings were substantiated by several studies of Kortebein et al.4951 They have studied the effects of prolonged periods of bed rest on muscle strength of major muscle groups and not surprisingly they found that prolonged periods of bed rest lead to a significant decrease in muscle strength. Decreasing muscle strength was also seen after short periods of bed rest. All of the earlier mentioned phenomena could result in significant morbidity after surgery and therefore need to be optimised.50,52-54 In general physical capacity predicts postoperative recovery, but seems to be more effects in frail and elderly patients undergoing major surgery. Therefore, nowadays there is an increasing interest in investigating a variety of PET and postoperative rehabilitation strategies ton optimise the surgical outcomes in this specific population.5558 However, there is no “one size fits all”, due to different patient characteristics, types of surgery and used programs (either PET or postoperative rehabilitation).5961

We can now consider the effects of PET to treat/optimise perioperative care as a proof of concept.44 However, we still do not understand the effects in different patient populations and of course the cellular and immunological processes that exercise interventions induce in this matter. In other words, according to several studies in different surgical specialities its effectiveness can be difference. Especially in patients scheduled for orthopaedic knee or hip replacement surgery, there are some controversies regarding the effects of perioperative exercise interventions, especially PET.62

Regarding types of exercise in these exercise interventions, the evidence is far from conclusive. Most of the studies investigate effects of aerobic training,63 however the combination of exercise types (for example, resistance and endurance training) can have even better effects. Unfortunately in perioperative medicine there is a lack of studies investigating these concepts, despite the cellular effects can be synergistic (with regards to tissue protein synthesis and aerobic capacity).6466

Despite the fact that there is not much known about the physiological principles of exercise interventions in the perioperative period, clinicians should consider to get patients and exercise test prior to the start of an exercise intervention. Cardiopulmonary exercise testing (CPET) is considered to be the gold standard in exercise testing, however could also be costly and time consuming.40,67 CPET is essential in determining the exercise tolerance of patients by indicating/calculating them in METs (Metabolic Equivalents of Time)40 One MET is defined as an oxygen use of 3.5 mL O2/kg/min, which indicates the energy used while being seated in a resting position.40,41 Climbing a flight of stairs or walking up a hill are activities associated with METs >4, and they are considered a “safe” threshold below which postoperative complications are more likely to occur.68

Psychological Status and Improvement of Comorbidities

Psychological distress is an often-overlooked problem that can have a significant effect on the postoperative convalescence of patients. In general, there are high rates of anxiety, depression and associated disorders in the surgical population.69 It is known that psychological distress in the form of anxiety and depressive disorders can have a negative impact on wound healing, infection rate, length of hospital stay and adherence to medical treatment, despite that the pathophysiological mechanism is still largely unknown.7073 A study by Mitchell et al.74 showed that anxiety disorders should be treated in the perioperative period to improve postoperative outcomes. Therefore, a psychologist should also be incorporated in the multidisciplinary team.

With the increasing age of surgical patients, but also patients scheduled for bariatric surgery,75 we need to take into account the presence of comorbidities. It is well known that extensive comorbid conditions are present in the majority of patients that undergo abdominal, bariatric, thoracic and cardiovascular surgery. High rates of coronary disease or congestive heart failure (>50%), hypertension (30–50%), COPD (30–40%) and chronic renal disease (5%) are seen in the surgical patient population.7678 The presence of these comorbidities can have a significant impact on postoperative recovery and the occurrence of functional decline after surgery. Therefore, efforts should be made to optimize these conditions prior to surgery. This might be the case in patients with cancer, COPD and heart failure.59,60,79

The burden of these morbidities should also be considered following bariatric surgery. A population-based study by Moonesinghe et al.80 investigated the burden of postoperative morbidity on overall survival and they showed a significant impact in a variety of surgical specialties.80 There must be a place for the optimisation of comorbid conditions (e.g. COPD, heart failure). Optimisation of medication use and/or lifestyle interventions could be incorporated in such a strategy.10

Preoperative Exercise Therapy

In general, there are very few data on the effectiveness of specific preoperative exercise therapy programs on CRF and functional performance following surgery. Some of the literature has been summarised by Pouwels et al.7 regarding its effects and perioperative timing.

In general for both the preoperative and postoperative there is no consensus what to do in terms of exercise interventions. Baillot et al.81 studied a preoperative exercise program with 35 supervised exercise sessions in 12 weeks. In total seven patients completed the full program and five of them had their bariatric surgery before the end of the program. The corresponding attendance rates were a median of 57.3% (32.5–77.6%). Significant weight and BMI reduction, reduction in neck circumference and fat mass were achieved (respectively; before; 144.3 kg, after; 140.2, p=0.07; before; 51.4 kg/m2, after; 47.2 kg/m2, p=0.004; before; 42.2 cm, after; 41.0 cm, p=0.016 and before; 72.1 kg, after; 69.1 kg, p=0.026). After the exercise program, several physical fitness measures increased significantly (six-minute walk test distance, time of the half-squat test and number of flexion during the arm curl test)81 This resulted in a high satisfaction with the intervention and the advice given by exercise professionals resulting in a significant improvement in the total Health-Related Quality Of Life (HRQOL) after the exercise intervention (p=0.012).81

With regards to anthropometric measurements, the study by Funderburk et al.82 showed similar results (a reduction in body weight after 12 weeks supervised aquatic exercises of 5.0 kg in the intervention group compared with 2.3 kg in the control group).82 Six-minute walking test distance increased with 10.4m, but in the control group it increased with 40.2m (after 12 weeks of aquatic exercises).82 HRQOL measurements were not significantly different between the intervention group and the control group. Bodily pain (as a sub-item of the Short Form 36 (SF-36) questionnaire) and depression scores (Beck Depression inventory) after 12 weeks decreased significantly (p<0.05).82

Hickey et al83 investigated a seven-day exercise training scheme consisting of 60 minute sessions once a day. They found no significant change in anthropometric variables (body weight and fat-free mass, but they did find a significant decrease in fasting plasma insulin (−41.7 pM). Strangely enough, there were not any corresponding changes in blood glucose levels and blood lipid concentrations.83 Also, no significant differences were found in maximal oxygen uptake (which was measured by VO2 peak).83

The findings of the study of Marcon et al.84 corresponded with the tendency found in previous studies. They investigated 24 weeks supervised low intensity endurance training and found significant changes in anthropometric variables; body weight (- 5.3kg (p<0.001)) and BMI (−1.9 kg/m2 (p<0.001)) decreased significantly. Also, significant decrease in systolic and diastolic blood pressure (−23.8 mmHg (p=0.007) and −14.4 mmHg (p=0.001) respectively) was found84 Finally, significant improvements were seen in blood lipid and glucose concentration and in six minute walking test distance (+69.8m (p<0.0001)) after 24 weeks exercise intervention.84

The Bari-Active trial from Bond et al.85 showed that an exercise intervention in the period six weeks prior to bariatric surgery has a significant improvement on physical activity patterns compared to the standard care group. These results were supported by a randomized controlled trial by Marcon et al.86 that showed a 4 month, twice weekly supervised program of low-intensity physical exercise can be valuable in the perioperative bariatric care.

Postoperative Exercise Therapy

In postoperative rehabilitation or postoperative exercise therapy in bariatric surgery, there are few studies that test the effectiveness of different exercise modes on outcomes. Further, the outcome measures appear to be heterogeneous.7,85,87,88

Stegen et al.89 investigated a 16 weeks postoperative exercise program after Roux en Y Gastric Bypass (GB) surgery. In this study, postoperative patients that completed the exercise program (GB+E) were compared with patients that only had GB surgery. Both groups had the same extent of weight loss and changes in other anthropometrics after four months (GB = −26.6 ± 14.6 kg; GB+E = −22.7 ± 5.7 kg), BMI (GB = −8.3 ± 4.1 kg/m2; GB+E = −8.1 ± 2.5 kg/m2) and waist circumference (GB = −20.3 ± 11.6 cm; GB+E = −17.2 ± 8.1 cm).89

In terms of exercise capacity, which was measured as ventilator anaerobic threshold (VAT) using a maximal bicycle ergometer, there were no significant differences. Both groups reached their VAT at the power (GB = 93 ± 24 W; GB+E = 90 ± 24 W) with an equal time of occurrence (GB = 270 ± 107 s; GB+E = 266 ± 133 s).89 Both groups showed no differences in peak exercise parameters (preoperative versus postoperatively; respectively peak oxygen uptake of 17.4 ± 4.9 mL/kg/min (GB) and 17.6 ± 3.2 mL/kg/min (GB+E)).89

However, the exercise training intervention showed promising effects regarding muscle loss after bariatric surgery. The untrained patients, who only had bariatric surgery showed a decrease in dynamic muscle strength (a decrease of 16% in quadriceps strength, 36% biceps strength and 39% triceps strength).89 Patients who had an exercise program after gastric bypass surgery (GB+E) prevented this decrease.89 Regarding static muscle strength (measured as handgrip strength, both groups had a decrease (respectively 18% and 7%).89

Castello-Simoes et al.90 investigated a three group 12 week post-bariatric exercise intervention, 1) a trained group (TG), 2) a eutrophic group (EG) and 3) a control group (CG).

Anthropometric changes were consistent with other studies and the TG and CG group showed significant weight reduction after 4 months. Also, both groups (TG and CG) showed a similar significant increase in the 6-minute walking test distance (6MWT)90 Finally a significant increase of the predicted forced vital capacity (pFVC) was found (before: 94.0 ± 3.1; after: 101.0 ± 2.5) in TG and a significant reduction in dyspnoea scores was found in the same group 4 months after bariatric surgery (before: 5.8 ± 0.6; after 2.7 ± 0.8).90 Shah et al.91 found similar results regarding weight loss after a high volume exercise program in 20 patients for 12 weeks. Interestingly, theyfound no difference in cardiovascular risk factors after compared to the control group.91

Berggren et al performed a study on skeletal muscle lipid oxidation before and after 10 days of endurance training in post-bariatric patients.92 Not surprisingly, they found significant weight loss after the exercise intervention. (p <0.05).92 Fatty acid oxidation in the muscle was not significantly different between patients with morbid obesity compared to the weight loss groups. Compared to lean individuals the oxidation of fatty acids was depressed (−45%; P<0.05). In contrast, ten days of exercise training increased fatty acid oxidation in the skeletal muscle of lean, obese and previously extreme obese subjects after weight loss (respectively +1.7-fold, +1.8-fold and +2.6-fold).92 These data suggest that there is reversibility of cellular oxidation processes through exercise interventions in patients after bariatric surgery.

Marc-Hernandez et al93 investigated the effects of a high-intensity exercise program has the ability to reduce weight regain three years after bariatric surgery. Twenty-one patients that had a sleeve gastrectomy three years ago were randomised in an exercise group that performed a 5-month supervised exercise program, compared to a control group that followed usual care.93 Body anthropometrics, physical fitness and cardiovascular parameters were collected before and after the training program. After the program, the exercise group showed to have significant reductions in fat mass, glycaemia and blood cholesterol levels. The control group showed an increase in body weight and fast mass. Two months after finalising the exercise program, the patients who had the exercise intervention showed similar results as the control group during the study. In particular, an increase in body weight and fat mass and higher blood glucose and cholesterol levels, compared to directly after the exercise program.93 This rebound effect might be due to exercise beliefs and exercise patterns that do not change after bariatric surgery. This was substantiated by a recent study done by Ouellette et al.94 They found that in the postoperative period, moderate-to-vigorous physical activity (MVPA) patterns did not significantly change, despite patients expectations.94 Is this context there might also be a behavioural component that can be treated.94

The data of the mentioned studies show that there might be beneficial effects on physical activity measurements, quality of life and traditional risk factors. In addition, it is important for future studies to take into account the metabolic effects of the surgical procedures prior to exercise and lifestyle interventions.6,95 Hopefully, future initiatives will be able to answer these important questions.96,97

Discussion

In surgical practice, perioperative exercise interventions seem to get more and more attention, due to beneficial effects on complication rate and patient convalescence. Also with the introduction of prehabilitation programs811,29 and their promising results in various surgical fields it is surprising that exercise interventions in bariatric surgery are so sparsely investigated. In the studies that investigate these perioperative exercise programs, there seems to be a beneficial effect on weight loss parameters, physical activity measurements and risk factors for cardiovascular diseases. However due to heterogeneous study designs, possible under powering and the lack of structured exercise training programs, no definitive conclusion can be drawn. All these factors hamper practical guidance and implementation in clinical practice.

Table 2 gives an overview of the common findings in the studies assessing exercise interventions in bariatric surgery. Figure 1 gives a conceptual framework of perioperative exercise interventions in bariatric surgery. The heterogeneity of exercise programs makes comparisons difficult and according to several studies it is not evident as to what the optimal exercise programs should be and what the timing should be around bariatric surgery.7

Table 2 Summary of Exercise Programs, Intensity, Duration, Supervision and Perioperative Timing

Figure 1 Conceptual framework of perioperative exercise interventions in bariatric surgery. Purple line: patients who do not receive any perioperative exercise intervention. Orange line: patients who only receive preoperative exercise training. Blue line: patients who receive preoperative and postoperative exercise training.

In general, it can be stated that exercise has beneficial total body effects. More specifically tremendous effects can be present in body composition changes, better blood pressure control, increase in insulin sensitivity, decrease of inflammation and presence of “inflammation” biomarkers and also subclinical carotid atherosclerosis (measured as Carotid Intima Media Thickness (CIMT)). The effects of exercise have been associated with physiological changes in the human cardiovascular system, for example removal of oxidized phospholipids from the vessel wall, stabilisation of atherosclerosis and positive changes in LDL cholesterol.98

These physiological changes correlated strongly with improvement of vascular function and in improvement of atherosclerosis (e.g. decreased burden of atherosclerosis).99

The evidence from the ARBITER 6 trial showed that exercise is superior in inducing these beneficial effects compared to medical treatment (with either statins or niacin).100 In other words, exercise training should be a part of every medical intervention or perioperative rehabilitations program.101

Despite a very large body of evidence that bariatric surgery is a longstanding intervention with great effects on the human body, it needs to be said that it also has consequences. One of them is muscle loss or otherwise called “muscle wasting”, which was showed in the study by Stegen et al.89 This can be explained by the rapid weight loss after bariatric surgery. In the study by Stegen et al the untrained (GB) group lost approximately 7.6 kg of muscle mass, which is 29.7% of the total body weight lost (−26.6 kg)89 Dieting, exercise interventions and also bariatric surgery results in the loss of fat-free mass. This was confirmed by studies done by Stiegler et al.102 and Chaston et al.103 They showed that there is a positive correlation between weight loss and fat-free mass loss (FFML). Very low caloric diets result in a greater FFML compared to moderate caloric diets. Bariatric surgery results in greater FFML than very low caloric diets.

A study by Webster et al.104 showed that there is a limit of FFML after bariatric surgery which is approximately 22% of the total weight loss. This is because of the functions of the muscle in resting metabolic rate, thermoregulation, oxidative capacity of the body and weight management. Exercise training can attenuate muscle atrophy and can maintain FFM during weight loss,102,103 but the value of a perioperative exercise program for bariatric surgery has not been investigated.

It is not clear whether or not there is a decrease of muscle strength contributes to poor health outcomes or risk after weight loss surgery. It is well known that obese individuals have higher absolute muscle strength compared to lean subjects, but there is lower relative muscle strength in terms of total body weight.105108 This gives patients an impaired functional capacity, which results in the fact that more strength is needed to handle a heavier body. Therefore, it might be important to prevent a decrease in muscle strength after bariatric surgery.

Conclusion

We can state that perioperative exercise programs in bariatric surgery might have beneficial effects on weight loss parameters, physical activity measurements and risk factors for cardiovascular diseases. However, the heterogeneity of exercise programs makes comparisons difficult and according to several studies reviewed in this paper it is not evident as to what the optimal exercise programs should be and what the timing should be around bariatric surgery. Future studies focused on the effectiveness of exercise intervention mode, intensity and timing before or after bariatric surgery to maximize cardiorespiratory fitness, physical function and reductions in cardiometabolic risk appears evident.

Author Contributions

All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; gave final approval of the version to be published; and agree to be accountable for all aspects of the work.

Disclosure

The authors report no conflicts of interest in this work.

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