Peanut Sensitivity and Allergic Rhinitis in Young Children are Associated with Attention-Deficit Hyperactivity Disorder Symptoms in Adolescence
Received 24 September 2019
Accepted for publication 17 April 2020
Published 26 May 2020 Volume 2020:16 Pages 1349—1357
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Jun Chen
Mindy Ming-Huey Guo,1 Liang-Jen Wang,2 Te-Yao Hsu,3 Kuender D Yang,4,5 Ho-Chang Kuo1
1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City, Taiwan; 2Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City, Taiwan; 3Department of Obstetrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City, Taiwan; 4Department of Pediatrics and Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; 5Institute of Biomedical Sciences, Mackay Medical School, Taipei, Taiwan
Correspondence: Kuender D Yang
Department of Pediatrics and Department of Medical Research, MacKay Memorial Hospital, Taipei No. 92, Sec. 2, Zhongshan North. Road, Zhongshan District, Taipei City, Taiwan
Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital, 123 Da-Pei Road, Niaosong District, Kaohsiung 83301, Taiwan
Tel +886 7 731-7123 ext. 8795
Fax +886 7 733-8009
Objective: Although childhood allergic diseases have been found to be associated with symptoms of attention-deficit hyperactivity disorder, the temporal relationship between these diseases remains unclear. In this study of 97 children, clinical examination and blood samples for total and specific IgE were collected at 6 and 12 years old.
Patients and Methods: We followed a total of 97 children from 6 to 12 years old. Clinical examination and blood samples for total and specific IgE were collected at 6 and 12 years old. Attention-deficit hyperactivity disorder and oppositional defiant disorder symptoms at 12 years old were evaluated using the Swanson, Nolan, and Pelham, Version IV Scale Parent Form.
Results: After accounting for the affect of confounding variables, we found that allergic rhinitis at 6 years old was associated with higher inattention score at 12 years old (β-coefficient 0.356, 95% CI 0.104– 0.609, p = 0.006). In addition, higher specific IgE levels for peanuts at 6 years of age were correlated with higher hyperactivity/impulsivity scores (β-coefficient 0.088, 95% CI 0.049– 0.126, p < 0.001), and higher specific IgE for peanuts at 12 years of age were correlated with higher opposition/defiance scores (β-coefficient 0.054, 95% CI 0.012– 0.096, p = 0.012) at 12 years old in our final linear regression models.
Conclusion: Allergic rhinitis and peanut sensitization in childhood may be associated with more symptoms of attention-deficit hyperactivity and oppositional defiant disorder in adolescence.
Keywords: allergic disease, attention deficit hyperactivity disorder, oppositional defiant disorder
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