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Papillon–Lefèvre syndrome: clinical presentation and management options

Authors Sreeramulu B, Shyam N, Ajay P, Suman P

Received 1 April 2015

Accepted for publication 8 May 2015

Published 15 July 2015 Volume 2015:7 Pages 75—81


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Christopher Okunseri

Video abstract presented by B Sreeramulu

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Basapogu Sreeramulu,1 Naragani DVN Shyam,2 Pilla Ajay,1 Pathipaka Suman1

1Department of Prosthodontics, 2Department of Oral Pathology, Government Dental College and Hospital, Hyderabad, Telangana State, India

Abstract: Papillon–Lefèvre syndrome (PLS) is a rare autosomal recessive disorder, characterized by diffuse palmoplantar keratoderma and precocious aggressive periodontitis, leading to premature loss of deciduous and permanent dentition at a very young age. Various etiopathogenic factors are associated with the syndrome, like immunologic alterations, genetic mutations, and the role of bacteria. Dentists play a significant role in the diagnosis and management of PLS as there are characteristic manifestations like periodontal destruction at an early age and an early eruption of permanent teeth. Here, we are presenting an elaborate review of PLS, its etiopathogenesis, clinical presentation, and management options.

Keywords: deciduous and permanent dentition, modified complete dentures, palmoplantar keratoderma, periodontitis

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