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Oxycodone vs Sufentanil in Patient-Controlled Intravenous Analgesia After Gynecological Tumor Operation: A Randomized Double-Blind Clinical Trial

Authors Dang SJ, Li RL, Wang J, Zeng WB, He Y, Yue HY, Li SY, Han LC

Received 1 November 2019

Accepted for publication 17 April 2020

Published 5 May 2020 Volume 2020:13 Pages 937—946

DOI https://doi.org/10.2147/JPR.S236933

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr E Alfonso Romero-Sandoval


Sha-Jie Dang,1,2,* Rui-Li Li,3,* Jun Wang,1 Wen-Bin Zeng,1 Yun He,1 Hui-Yu Yue,1 Si-Yuan Li,4 Li-Chun Han2,5

1Department of Anesthesia, Shaanxi Provincial Cancer Hospital, Xi’an, Shaanxi, People’s Republic of China; 2The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, People’s Republic of China; 4Department of Anesthesia, The Second Affiliated Hospital of Xian Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 5Department of Anesthesia, Xi’an Daxing Hospital, Xi’an, Shaanxi, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Li-Chun Han
Department of Anesthesia, Xi’an Daxing Hospital, Xi’an, Shaanxi 710016, People’s Republic of China
Email hanlichun696@163.com
Si-Yuan Li
Department of Anesthesia, The Second Affiliated Hospital of Xian Jiaotong University, Xi’an, Shaanxi 710004, People’s Republic of China
Email foxlsy@163.com

Background: This study aims to compare analgesic effect and side effects of oxycodone and sufentanil in transition analgesia and patient-controlled intravenous analgesia (PCIA) after gynecological tumor operation under general anesthesia.
Patients and Methods: A prospective, randomized, double-blind research was conducted. Patients undergoing elective gynecological tumor surgery were randomized into four groups: Group S (sufentanil transition analgesia and sufentanil PCIA), Group OS (oxycodone transition analgesia and sufentanil PCIA), Group SO (sufentanil transition analgesia and oxycodone PCIA) and Group O (oxycodone transition analgesia and oxycodone PCIA). The primary outcomes were Numerical Rating Scale (NRS) at rest and coughing, accumulated opioid consumption in PCIA and patients’ satisfaction.
Results: Patients in Group OS and Group O showed shorter time of consciousness recovery and extubation after surgery. Accumulated opioid consumption in PCIA (equal to morphine) in Group SO and Group O was significantly less than that in Group S and Group OS. Patients in Group O showed lower NRS at rest and coughing, but higher patients’ satisfaction 3, 24 and 48 hours after surgery. Patients in Group SO and Group O showed a shorter time of intestinal recovery, first feeding and first-time movement.
Conclusion: Both oxycodone and sufentanil provided adequate pain relief in transitional analgesia and PCIA treatment after surgery. Oxycodone without background infusion showed less analgesic drug consumption and faster recovery than sufentanil with background infusion in PCIA after gynecological tumor operation under general anesthesia.

Keywords: gynecological tumor operation, oxycodone, transition analgesia, patient-controlled intravenous analgesia, sufentanil

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