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Outcome of pregnancy after renal transplantation

Authors Mohamed Hassan S, Fahmy R, Omran EF, Hussein EA, Ramadan W, Abdelazim DF

Received 5 August 2017

Accepted for publication 15 November 2017

Published 26 January 2018 Volume 2018:10 Pages 65—68

DOI https://doi.org/10.2147/IJWH.S148386

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Elie Al-Chaer


Sarah Mohamed Hassan, Radwa Fahmy, Eman Fawzy Omran, Eman Aly Hussein, Wafaa Ramadan, Dalia Farouk Abdelazim

Obstetrics and Gynecology Department, Cairo University, Cairo, Egypt

Aim: The aim of our study was to compare the outcome of pregnancy in patients who became pregnant within 24 months of renal transplantation and patients who became pregnant more than 24 months after renal transplantation.
Materials and methods: The sample population of our prospective cohort study comprised of 44 patients who became pregnant following renal transplantation. In all cases, living donors were used for renal transplantation. The patients were allocated into either group A, which included 24 patients who became pregnant more than 24 months after renal transplantation, or group B, which included 20 patients who inadvertently became pregnant within 24 months of renal transplantation. Serum creatinine and 24-hour urinary protein concentration were measured each trimester. The incidences of preeclampsia and gestational diabetes, the timing and mode of delivery, the rate of preterm labor, and the mean fetal birth weight were determined.
Results: The mean gestational ages in groups A and B were 35.8±3 weeks and 34.1±2.5 weeks, respectively. The mean fetal birth weights in groups A and B were 2,480±316 g and 2,284.5±262 g, respectively. These differences were statistically significant. The incidence of preterm labor was 45.8% in group A and 55% in group B. Proteinuria was significantly higher in group B during the third trimester of pregnancy. Preeclampsia occurred in 25% of the cases in group A and 30% of the cases in group B; this difference was not statistically significant. Gestational diabetes occurred in 2 out of 24 cases in group A and 2 out of 20 cases in group B. For group A and group B, normal vaginal delivery occurred in 58.3% and 55% of cases, respectively, and cesarean section was performed in 41.6% and 45% of cases, respectively.
Conclusion: A longer interval between renal transplantation and pregnancy is associated with better pregnancy outcome.

Keywords: pregnancy, renal transplantation, time interval

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