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Olfactory ensheathing cell transplantation for a patient with chronic sciatic nerve injury

Authors Zhang F, Meng XZ, Lu F, Liu AX, Huang HY

Received 24 August 2016

Accepted for publication 7 October 2016

Published 28 December 2016 Volume 2017:5 Pages 1—4

DOI https://doi.org/10.2147/JN.S120524

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 4

Editor who approved publication: Prof. Dr. Hari Shanker Sharma


Feng Zhang,1,2 Xiangzhi Meng,2 Fang Lu,2 Aixian Liu,2 Hongyun Huang1,2

1Cell Therapy Center, Beijing Hongtianji Neuroscience Academy, 2Neurorehabilitation Center, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, People’s Republic of China

Objective: To observe the result of olfactory ensheathing cell (OEC) transplantation in a patient with chronic sciatic nerve injury.
Case report:
A 53-year-old male patient with chronic (1 year) sciatic nerve injury on left side received OEC transplantation at the lesion site. He received follow-up assessment according to the American Spinal Injury Association standard at 10 days, 6 months, and 1 year after OEC therapy. The muscle strength of his left lower limb increased and numbness decreased during the early stage of cell therapy. His motor function improved with each evaluation. His limp walking gait recovered, and numbness sensation got nearly normal after 1 year of follow-up. There were no side effects.
Conclusion: OEC transplantation may be an option for chronic peripheral (sciatic) nerve injury.

Keywords: olfactory ensheathing cell transplantation, sciatic nerve injury, peripheral nerve injury, function improvement, neurorestoration

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