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Nonobese, exercising children diagnosed with dyslipidemia have normal C-reactive protein

Authors Salazar Vázquez M, Salazar Vázquez B, Intaglietta M, Cabrales P

Published 30 September 2008 Volume 2009:5 Pages 65—72


Review by Single anonymous peer review

Peer reviewer comments 3

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Miguel Arturo Salazar Vázquez1, Beatriz Yadira Salazar Vázquez2,3, M Intaglietta3, Pedro Cabrales4

1Facultad de Ciencias Químicas Gómez Palacio, Universidad Juárez del Estado de Durango, Dgo., México; 2Faculty of Medicine, Universidad Juárez del Estado de Durango, Victoria de Durango Dgo., México; 3Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA; 4La Jolla Bioengineering Institute, La Jolla, CA, USA

Abstract: Nonobese children age 10.4 ± 1.1 years diagnosed with dyslipidemia (n = 51) were compared to normal children age 10.8 ± 1.1 years (n = 38). Affected individuals had increased total cholesterol: 223 ± 23 vs 152 ± 17 mg/dl, p < 0.001; and decreased high-density lipoprotein-cholesterol: 41.9 ± 4.1 vs 57.6 ± 5.7 mg/dl, p < 0.001 and triglycerides: 90.8 ± 40.5 vs 65.7 ± 25.0 mg/dl, p < 0.002. Fasting glucose was also significantly elevated (p < 0.02). All other parameters, including blood pressure, were not statistically different between groups. The concentration of C-reactive protein was not statistically different between groups. Analysis of medical records showed that this anomaly may be related to this group (as well as the control group) performing regular, daily exercise. This activity was quantified via a self administered questionnaire, and found to be statistically identical in controls and dyslipidemic individuals. Exercise is associated with the release of antiinflammatory cytokines, therefore our results support the contention that it is a significant factor in promoting health conditions from an early stage in life.

Keywords: dyslipidemia, C-reactive protein, children, exercise, inflammation, diabetes, obesity, metabolic syndrome, hispanics

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