Nomograms to predict overall survival and cancer-specific survival in patients with adrenocortical carcinoma
Received 11 September 2018
Accepted for publication 24 October 2018
Published 13 December 2018 Volume 2018:10 Pages 6949—6959
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Andrew Yee
Peer reviewer comments 2
Editor who approved publication: Dr Chien-Feng Li
Yan Li,1 Xiaohui Bian,2 Junyu Ouyang,2 Shuyi Wei,2 Meizhi He,2 Zelong Luo1
1Department of Oncology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China; 2The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China
Purpose: To develop nomogram models to predict individualized estimates of overall survival (OS) and cancer-specific survival (CSS) in patients with adrenocortical carcinoma (ACC).
Patients and methods: A total of 751 patients with ACC were identified within the Surveillance Epidemiology, and End Results (SEER) database between 1973 and 2015. The predictors comprised marital status, sex, age at diagnosis, year of diagnosis, laterality, histologic grade, ethnicity, historic stage, radiation therapy, chemotherapy, and surgery of primary site. Based on the results of the multivariate logistic regression analyses, the nomogram models were used for predicting OS and CSS in patients with ACC. The nomograms were tested using concordance index (C-index) and calibration curves.
Results: In univariate and multivariate analyses of OS, OS was significantly associated with age at diagnosis, year of diagnosis, histologic grade, historic stage, and chemotherapy. In univariate and multivariate analyses of CSS, age at diagnosis, year of diagnosis, historic stage, and chemotherapy were the independent risk factors with CSS. These characteristics were included in the nomograms predicting OS and CSS. The nomograms demonstrated good accuracy in predicting OS and CSS, with the C-index of 0.677 and 0.672.
Conclusion: These clinically useful tools predicted OS and CSS in patients with ACC using readily available clinicopathologic factors and could aid individualized clinical decision making.
Keywords: adrenocortical carcinoma, nomogram, overall survival, cancer-specific survival
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