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Depression in Parkinson’s disease

Authors Rana MA, Hafez K

Received 16 August 2012

Accepted for publication 16 August 2012

Published 2 April 2012 Volume 2012:2 Pages 34—35

DOI https://doi.org/10.2147/JPRLS.S37083


Mohammed A. Rana, Kevin Hafez

Parkinson’s Clinic of Eastern Toronto, Toronto, Canada

Parkinson's disease (PD) has both motor and non-motor symptoms. There is growing evidence that some of the non-motor symptoms may antedate the motor symptoms and can cause increasing disabling as the disease progresses. Depression is one of the important symptoms of PD.1 About 40 percent of patients with PD may have anhedonia, lack of initiative and assertiveness. The majority of the patients have dysthymia; however, some patients may meet the DSM-IV criteria for major depression. Nonetheless, loss of interest, fatigue, irritability, lack of energy, indecisiveness and sadness are more frequent in PD. Depression may precede the onset of motor symptoms of PD by many years in some cases.2

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