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Mn2+-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy

Authors Xi J, Da L, Yang C, Chen R, Gao L, Fan L, Han J

Received 12 January 2017

Accepted for publication 3 April 2017

Published 24 April 2017 Volume 2017:12 Pages 3331—3345

DOI https://doi.org/10.2147/IJN.S132270

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Lei Yang


Juqun Xi,1–3 Lanyue Da,1 Changshui Yang,1 Rui Chen,4 Lizeng Gao,2 Lei Fan,5 Jie Han5

1Pharmacology Department, Medical School, Yangzhou University, 2Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, 3Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, 4Department of Nephrology, Subei People’s Hospital, Yangzhou University, 5School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China

Abstract: Nanoparticle drug delivery carriers, which can implement high performances of multi-functions, are of great interest, especially for improving cancer therapy. Herein, we reported a new approach to construct Mn2+-coordinated doxorubicin (DOX)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles as a platform for synergistic chemo-photothermal tumor therapy. DOX-loaded PLGA (DOX/PLGA) nanoparticles were first synthesized through a double emulsion-solvent evaporation method, and then modified with polydopamine (PDA) through self-polymerization of dopamine, leading to the formation of PDA@DOX/PLGA nanoparticles. Mn2+ ions were then coordinated on the surfaces of PDA@DOX/PLGA to obtain Mn2+-PDA@DOX/PLGA nanoparticles. In our system, Mn2+-PDA@DOX/PLGA nanoparticles could destroy tumors in a mouse model directly, by thermal energy deposition, and could also simulate the chemotherapy by thermal-responsive delivery of DOX to enhance tumor therapy. Furthermore, the coordination of Mn2+ could afford the high magnetic resonance (MR) imaging capability with sensitivity to temperature and pH. The results demonstrated that Mn2+-PDA@DOX/PLGA nanoparticles had a great potential as a smart theranostic agent due to their imaging and tumor-growth-inhibition properties.

Keywords: PLGA nanoparticles, polydopamine, chemo-photothermal therapy, smart theranostic agent

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