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Misdiagnosed atypical paroxysmal kinesigenic dyskinesia: a case report

Authors Pan F, Li S, Li H, Xu Y, Huang M

Received 24 January 2018

Accepted for publication 18 April 2018

Published 5 June 2018 Volume 2018:14 Pages 1433—1435

DOI https://doi.org/10.2147/NDT.S163646

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Professor Wai Kwong Tang

Fen Pan,1,2 Shangda Li,3 Haimei Li,3 Yi Xu,1,2 Manli Huang1,2

1Department of Psychiatry, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China; 2The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou 310003, China; 3School of Medicine, Zhejiang University, Hangzhou 310000, China

Background: Paroxysmal kinesigenic dyskinesia (PKD) is characterized by sudden episodes of involuntary movements. PKD is a very rare movement disorder, and correct clinical diagnosis is often a challenge.
Case: We present the case of a 23-year-old female with PKD. The patient showed episodes of twisting movements for 3 years. The symptoms lasted for about 5–10 minutes and subsided spontaneously. She was diagnosed as having epilepsy, and depressive and anxiety disorders successively. However, her symptoms did not alleviate after taking sodium valproate and antidepressants. Though there were no mutations in her PRRT2 gene, carbamazepine was used for treatment and was effective in controlling her symptoms.
Conclusion: The clinical features of PKD patients are not always typical; therefore, it is important to distinguish PKD from the other subtypes of paroxysmal dyskinesia and psychogenic disorders.

Keywords: paroxysmal kinesigenic dyskinesia, misdiagnosis, PRRT2 gene

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