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miR-486-5p suppresses prostate cancer metastasis by targeting Snail and regulating epithelial–mesenchymal transition

Authors Zhang XG, Zhang T, Yang K, Zhang MH, Wang KM

Received 15 July 2016

Accepted for publication 14 September 2016

Published 8 November 2016 Volume 2016:9 Pages 6909—6914

DOI https://doi.org/10.2147/OTT.S117338

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 3

Editor who approved publication: Dr William Cho


Xiaoguang Zhang,1 Tong Zhang,2 Kuo Yang,3 Minghao Zhang,1 Keming Wang1

1Department of Urology, Tianjin Third Central Hospital, Tianjin, 2Department of Urology, Provincial Hospital Affiliated to Shandong University, Jinan, 3Tianjin Institute of Urology, Tianjin, People’s Republic of China

Abstract: The most common cause of death from prostate cancer (PCa) is metastases. There is an increasing body of evidence that microRNAs play an important role in the development of PCa by regulating target genes involved in tumor metastasis. Here, we identified that expression of miR-486-5p was decreased in metastatic C4-2 cells compared to non-metastatic LNCaP cells. Further validation in clinical samples showed that miR-486-5p expression was significantly decreased in metastatic PCa tissues compared to localized PCa tissues. Functional studies demonstrated that increased miR-486-5p expression can suppress cell migration and the invasive ability of C4-2 cells. Moreover, Snail, a key regulator of the epithelial–mesenchymal transition, was verified as a target gene of miR-486-5p. In conclusion, these findings suggest that miR-486-5p plays a suppressive role in mediating the migration and invasion of PCa by directly suppressing the protein expression of Snail and may provide a potential therapeutic target for the disease.

Keywords: microRNA, prostate cancer, metastasis, EMT

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