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Metabolic syndrome and its components associated with endothelial dysfunction in chronic kidney disease patients

Authors Bai Q, Lai, Zhang A, Lu, Tian, Fan M, Wang, Wang T

Received 18 October 2011

Accepted for publication 11 November 2011

Published 6 January 2012 Volume 2012:8 Pages 15—21


Review by Single anonymous peer review

Peer reviewer comments 3

Qiong Bai, Xuan Lai, Ai-Hua Zhang, Xin-Hong Lu, Shun-Li Tian, Min-Hua Fan, Yue Wang, Tao Wang
Division of Nephrology, Peking University Third Hospital, Beijing, People's Republic of China

Background: Cardiovascular disease is more common in patients with chronic kidney disease (CKD) than in the general population. Endothelial dysfunction is an early predictor of cardiovascular events.
Objective: We conducted a cross-sectional study in CKD patients to explore the association of metabolic syndrome (MetS) components with endothelial cell function.
Methods: We evaluated clinical and laboratory data in 161 CKD patients from stage 1 to stage 5. Endothelial function was estimated by flow-mediated dilatation (FMD) of the brachial artery and expressed as percentage change relative to baseline diameter. MetS was defined according to the National Cholesterol Education Program-Adult Treatment Panel III criteria.
Results: Patients were grouped into two groups according to whether or not they had MetS. FMD was significantly lower in the MetS group than in the group without MetS (P = 0.012). In a Pearson's correlation analysis, FMD was significantly negatively correlated with waist circumference in women (r = –0.223, P = 0.03) and fasting blood glucose (r = –0.186, P = 0.001). Multiple linear regression analysis showed that fasting blood glucose was an independently associated factor for FMD.
Conclusion: MetS and some components of MetS (waist circumference in women and fasting blood glucose) are closely associated with a decreased FMD in CKD patients.

Keywords: metabolic syndrome, endothelial dysfunction, flow-mediated dilatation, chronic kidney disease

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