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Mesoporous magnesium silicate-incorporated poly(ε-caprolactone)-poly(ethylene glycol)- poly(ε-caprolactone) bioactive composite beneficial to osteoblast behaviors

Authors Niu Y, Dong W, Guo H, Deng Y, Guo L, An X, He D, Wei J, Li M, Wang H, Chen J, Shen H, Boccaccini B, Yao X

Received 11 December 2013

Accepted for publication 7 February 2014

Published 27 May 2014 Volume 2014:9(1) Pages 2665—2675


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Yunfei Niu,1,* Wei Dong,1,* Han Guo,2 Yuhu Deng,3 Lieping Guo,1 Xiaofei An,1 Dawei He,1 Jie Wei,3 Ming Li1

1Department of Orthopedic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China; 2Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China; 3Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People's Republic of China

*These authors contributed equally to this work

Abstract: Mesoporous magnesium silicate (m-MS) and poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL) composite (m-MPC) was synthesized by solvent casting method. The results suggest that the mechanical properties of compressive strength and elastic modulus, as well as hydrophilicity, of the m-MPC increased with increase of m-MS content in the composites. In addition, the weight loss of the m-MPC improved significantly with the increase of m-MS content during composite soaking in phosphate-buffered saline for 10 weeks, indicating that incorporation of m-MS into PCL-PEG-PCL could enhance the degradability of the m-MPC. Moreover, the m-MPC with 40 w% m-MS could induce a dense and continuous apatite layer on its surface after soaking in simulated body fluid for 5 days, which was better than m-MPC 20 w% m-MS, exhibiting excellent in vitro bioactivity. In cell cultural experiments, the results showed that the attachment and viability ratio of MG63 cells on m-MPC increased significantly with the increase of m-MS content, showing that the addition of m-MS into PCL-PEG-PCL could promote cell attachment and proliferation. The results suggest that the incorporation of m-MS into PCL-PEG-PCL could produce bioactive composites with improved hydrophilicity, degradability, bioactivity, and cytocompatibility.

Keywords: PCL-PEG-PCL, degradation, cytocompatibility, cell attachment, cell proliferation

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