Back to Journals » Neuropsychiatric Disease and Treatment » Volume 11

Memantine for the treatment of frontotemporal dementia: a meta-analysis

Authors Kishi T, Matsunaga S, Iwata N

Received 14 August 2015

Accepted for publication 20 October 2015

Published 12 November 2015 Volume 2015:11 Pages 2883—2885


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Miao Sun

Peer reviewer comments 3

Editor who approved publication: Professor Wai Kwong Tang

Taro Kishi, Shinji Matsunaga, Nakao Iwata

Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan

Background: There is no conclusive evidence supporting the efficacy of memantine in frontotemporal dementia (FTD). We conducted a comprehensive meta-analysis of memantine concerning the efficacy and tolerability of memantine in FTD.
Methods: Studies were identified through searches of PubMed, databases of the Cochrane Library, and PsycINFO citations up to April 10, 2015. Outcomes were Clinical Global Impression (primary), Mini-Mental State Examination, Neuropsychiatric Inventory, and Zarit Burden Interview scores as well as all-cause discontinuation. Standardized mean difference and risk ratio with 95% confidence interval were calculated.
Results: Two randomized controlled trials (RCTs) (total n=130) met the inclusion criteria. Memantine was marginally superior to placebo as assessed by the Clinical Global Impression scores (standardized mean difference =-0.34, 95% confidence interval =-0.68–0.01, P=0.06). However, there were no significant differences in Mini-Mental State Examination, Neuropsychiatric Inventory, and Zarit Burden Interview scores as well as all-cause discontinuation between memantine and placebo.
Conclusion: Our results suggest that memantine may benefit FTD patients. However, because only two randomized controlled trials have addressed this issue, further studies using larger samples are needed.

Keywords: frontotemporal dementia, memantine, meta-analysis, Clinical Global Impression

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

Comparative efficacy and safety of antipsychotics in the treatment of schizophrenia: a network meta-analysis in a Japanese population

Kishi T, Ikuta T, Matsunaga S, Matsuda Y, Oya K, Iwata N

Neuropsychiatric Disease and Treatment 2017, 13:1281-1302

Published Date: 11 May 2017

Escitalopram versus paroxetine controlled release in major depressive disorder: a randomized trial

Kishi T, Matsuda Y, Matsunaga S, Moriwaki M, Otake Y, Akamatsu K, Okochi T, Hirano S, Funahashi T, Okuda M, Tabuse H, Fujita K, Iwata N

Neuropsychiatric Disease and Treatment 2017, 13:117-125

Published Date: 6 January 2017

A randomized trial of aripiprazole vs blonanserin for the treatment of acute schizophrenia and related disorders

Kishi T, Matsuda Y, Matsunaga S, Mukai T, Moriwaki M, Tabuse H, Fujita K, Iwata N

Neuropsychiatric Disease and Treatment 2016, 12:3041-3049

Published Date: 28 November 2016

Early prediction of blonanserin response in Japanese patients with schizophrenia

Kishi T, Matsuda Y, Fujita K, Iwata N

Neuropsychiatric Disease and Treatment 2014, 10:1861-1866

Published Date: 23 September 2014

Comparative clinical profile of mirtazapine and duloxetine in practical clinical settings in Japan: a 4-week open-label, parallel-group study of major depressive disorder

Nagao K, Kishi T, Moriwaki M, Fujita K, Hirano S, Yamanouchi Y, Funahashi T, Iwata N

Neuropsychiatric Disease and Treatment 2013, 9:781-786

Published Date: 5 June 2013

Readers of this article also read:

The impact of nonmotor symptoms on quality of life in patients with Parkinson's disease in Taiwan

Liu WM, Lin RJ, Yu RL, Tai CH, Lin CH, Wu RM

Neuropsychiatric Disease and Treatment 2015, 11:2865-2873

Published Date: 11 November 2015

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010