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Mechanism linking diabetes mellitus and obesity

Authors Al-Goblan A, Al-Alfi M, Khan M

Received 8 May 2014

Accepted for publication 25 August 2014

Published 4 December 2014 Volume 2014:7 Pages 587—591

DOI https://doi.org/10.2147/DMSO.S67400

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Ming-Hui Zou


Video abstract presented by Muhammad Khan.

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Abdullah S Al-Goblan,1 Mohammed A Al-Alfi,1 Muhammad Z Khan2

1Diabetes Center, King Fahad Specialist Hospital, Buraidah, Qassim, Kingdom of Saudi Arabia; 2Sulaiman AlRajhi Colleges, Al Bukairiyah, Kingdom of Saudi Arabia

Abstract: Body mass index has a strong relationship to diabetes and insulin resistance. In obese individuals, the amount of nonesterified fatty acids, glycerol, hormones, cytokines, proinflammatory markers, and other substances that are involved in the development of insulin resistance, is increased. The pathogenesis in the development of diabetes is based on the fact that the β-islet cells of the pancreas are impaired, causing a lack of control of blood glucose. The development of diabetes becomes more inevitable if the failure of β-islet cells of the pancreas is accompanied by insulin resistance. Weight gain and body mass are central to the formation and rising incidence of type 1 and type 2 diabetes. This literature review will demonstrate the facts that link obesity with insulin resistance and pancreatic β-cell dysfunction. In conclusion, new approaches in managing and preventing diabetes in obese individuals must be studied and investigated based on the facts.

Keywords: diabetes mellitus, obesity, insulin resistance

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