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Matrix metalloproteinase-7 may serve as a novel biomarker for cervical cancer

Authors Zhu L, Zheng X, Du Y, Xing Y, Xu K, Cui L

Received 31 December 2017

Accepted for publication 26 April 2018

Published 20 July 2018 Volume 2018:11 Pages 4207—4220

DOI https://doi.org/10.2147/OTT.S160998

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Justinn Cochran

Peer reviewer comments 3

Editor who approved publication: Dr William Cho


Linyan Zhu,* Xiaojiao Zheng,* Yongming Du, Yan Xing, Kejun Xu, Lining Cui

Department of Obstetrics and Gynaecology, Ningbo First Hospital, Ningbo, Zhejiang, People’s Republic of China

*These authors contributed equally to this work

Background: The biological and clinical significance of matrix metalloproteinase-7 (MMP-7) in cervical cancer remains unknown. Here, we investigated the function of MMP-7 in cervical cancer cells and evaluated its clinical significance in both tissues and serum from cervical cancer patients.
Methods: First, we analyzed the expression of MMP-7 in cervical cancer using Oncomine microarray data and examined its expression in cervical tissues by quantitative real-time polymerase chain reaction and Western blotting. Second, we utilized gene silencing to explore the role of MMP-7 in cells. Finally, we examined the MMP-7 levels in patients with cervical cancer and normal serum by enzyme-linked immunosorbent assay. Moreover, we further investigated the relationship between MMP-7 expression and pathological features.
Results: The mRNA and protein MMP-7 levels were higher in cervical cancer tissues than in healthy controls. Silencing of MMP-7 significantly decreased cervical cancer cell proliferation, migration, and invasion. The serum MMP-7 levels were significantly higher in cervical cancer patients than in healthy subjects (P<0.01). Further, higher MMP-7 expression was associated with increased lymph metastasis (P=0.021), pathological grade (P=0.039, P=0.047), and clinical stage (P=0.049, P=0.046).
Conclusion: MMP-7 appears to act as an oncogene in cervical cancer cells and is involved in cell proliferation, migration, and invasion. MMP-7 expression was significantly higher in the tissue and serum of cervical cancer patients compared to healthy individuals and was correlated with increased pathalogical grade, clinical stage, and lymph metastasis. Therefore, our data provide novel evidence that MMP-7 may be a clinically relevant biomarker for cervical cancer.

Keywords: cervical cancer, matrix metalloproteinase-7, biomarker, migration, invasion

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