Back to Journals » Neuropsychiatric Disease and Treatment » Volume 12

Mania following ketamine abuse

Authors Lu Y, Lin C, Lane H

Received 6 October 2015

Accepted for publication 2 December 2015

Published 27 January 2016 Volume 2016:12 Pages 237—239

DOI https://doi.org/10.2147/NDT.S97696

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Chin-Pang Lee

Peer reviewer comments 2

Editor who approved publication: Professor Wai Kwong Tang


Yuan-Yuan Lu,1 Chieh-Hsin Lin,2,3 Hsien-Yuan Lane1,2,4

1Department of Psychiatry, China Medical University Hospital, 2Graduate Institute of Clinical Medical Science, China Medical University, Taichung, 3Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 4Center for Drug Abuse and Addiction, China Medical University Hospital, Taichung, Taiwan

Abstract: Ketamine, a noncompetitive antagonist of the N-methyl-d-aspartate (NMDA) receptor, has multiple clinical uses. On the other hand, ketamine abuse or recreational use has been gaining increasing attention. Induction of mania and psychotic symptoms has been reported in a patient receiving IV ketamine therapy for reflex sympathetic dystrophy. We here report a 26 year-old man who abused ketamine by inhalation for 12 months and developed manic-like symptoms after ketamine use. This case suggests a possible relationship between manic symptoms and ketamine abuse. To the best of our knowledge, this may be the first report regarding mania after recreational use of ketamine.

Keywords: ketamine, mania, antidepressant, bipolar

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]